Incidental Mutation 'R3740:Zfp605'
| ID |
270335 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp605
|
| Ensembl Gene |
ENSMUSG00000023284 |
| Gene Name |
zinc finger protein 605 |
| Synonyms |
A830023I12Rik |
| MMRRC Submission |
040726-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R3740 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
110257958-110277660 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 110276564 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Tryptophan
at position 561
(G561W)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108147
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086686]
[ENSMUST00000112528]
[ENSMUST00000147631]
|
| AlphaFold |
E9QAH2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000086686
AA Change: G561W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000083891
Gene: ENSMUSG00000023284
AA Change: G561W
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
66 |
3.75e-28 |
SMART |
|
low complexity region
|
147 |
159 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
200 |
222 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
4.99e1 |
SMART |
|
ZnF_C2H2
|
443 |
465 |
5.4e1 |
SMART |
|
ZnF_C2H2
|
471 |
493 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
499 |
521 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
527 |
549 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
555 |
577 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
583 |
605 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
611 |
633 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
639 |
661 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
667 |
689 |
2.09e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112528
AA Change: G561W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108147
Gene: ENSMUSG00000023284
AA Change: G561W
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
66 |
3.75e-28 |
SMART |
|
low complexity region
|
147 |
159 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
200 |
222 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
4.99e1 |
SMART |
|
ZnF_C2H2
|
443 |
465 |
5.4e1 |
SMART |
|
ZnF_C2H2
|
471 |
493 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
499 |
521 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
527 |
549 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
555 |
577 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
583 |
605 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
611 |
633 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
639 |
661 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
667 |
689 |
2.09e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144089
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147631
|
| SMART Domains |
Protein: ENSMUSP00000122236
Gene: ENSMUSG00000023284
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
66 |
3.75e-28 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
94% (29/31) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb3 |
T |
C |
1: 25,865,535 (GRCm39) |
R103G |
probably benign |
Het |
| Atp8b2 |
C |
G |
3: 89,853,338 (GRCm39) |
A726P |
probably benign |
Het |
| Bbox1 |
A |
G |
2: 110,135,922 (GRCm39) |
I19T |
possibly damaging |
Het |
| Ctso |
G |
A |
3: 81,859,556 (GRCm39) |
V288I |
probably benign |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Fam135a |
A |
T |
1: 24,053,892 (GRCm39) |
M1215K |
probably damaging |
Het |
| Fam174b |
T |
C |
7: 73,390,578 (GRCm39) |
|
probably null |
Het |
| Fgfr1op2 |
A |
G |
6: 146,496,731 (GRCm39) |
I190V |
possibly damaging |
Het |
| Flt1 |
G |
A |
5: 147,536,403 (GRCm39) |
R813W |
probably damaging |
Het |
| Gm6489 |
T |
A |
1: 31,326,764 (GRCm39) |
|
noncoding transcript |
Het |
| Hacd3 |
T |
C |
9: 64,928,755 (GRCm39) |
E24G |
possibly damaging |
Het |
| Kat6b |
T |
G |
14: 21,720,112 (GRCm39) |
M1488R |
probably damaging |
Het |
| Kcnk3 |
T |
C |
5: 30,779,274 (GRCm39) |
V108A |
possibly damaging |
Het |
| Kif5a |
A |
G |
10: 127,079,337 (GRCm39) |
I287T |
probably damaging |
Het |
| Mical1 |
A |
C |
10: 41,355,067 (GRCm39) |
D192A |
probably benign |
Het |
| Mov10l1 |
A |
G |
15: 88,896,345 (GRCm39) |
N678D |
possibly damaging |
Het |
| Nup210l |
A |
T |
3: 90,114,701 (GRCm39) |
M1759L |
probably benign |
Het |
| Optn |
C |
A |
2: 5,039,009 (GRCm39) |
M371I |
possibly damaging |
Het |
| Pik3cg |
T |
C |
12: 32,255,223 (GRCm39) |
K255E |
probably damaging |
Het |
| Rims1 |
A |
T |
1: 22,443,667 (GRCm39) |
V380D |
probably damaging |
Het |
| Serpinb6e |
T |
A |
13: 34,022,943 (GRCm39) |
I147F |
probably benign |
Het |
| Slc13a1 |
T |
C |
6: 24,134,476 (GRCm39) |
M136V |
probably damaging |
Het |
| Syngr4 |
T |
C |
7: 45,545,194 (GRCm39) |
E5G |
possibly damaging |
Het |
| Tiam2 |
A |
G |
17: 3,464,388 (GRCm39) |
D39G |
possibly damaging |
Het |
| Tmem88b |
A |
G |
4: 155,869,884 (GRCm39) |
L59P |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,620,703 (GRCm39) |
K13995* |
probably null |
Het |
| Vmn1r225 |
A |
G |
17: 20,723,261 (GRCm39) |
Q234R |
possibly damaging |
Het |
| Vmn2r107 |
A |
G |
17: 20,595,151 (GRCm39) |
N568S |
probably benign |
Het |
| Zfp69 |
T |
A |
4: 120,788,071 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Zfp605 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02388:Zfp605
|
APN |
5 |
110,275,506 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0010:Zfp605
|
UTSW |
5 |
110,275,400 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0357:Zfp605
|
UTSW |
5 |
110,272,245 (GRCm39) |
missense |
probably benign |
|
|
R0383:Zfp605
|
UTSW |
5 |
110,276,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1017:Zfp605
|
UTSW |
5 |
110,275,860 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1663:Zfp605
|
UTSW |
5 |
110,275,451 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1688:Zfp605
|
UTSW |
5 |
110,276,907 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1752:Zfp605
|
UTSW |
5 |
110,271,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Zfp605
|
UTSW |
5 |
110,275,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2173:Zfp605
|
UTSW |
5 |
110,275,323 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3742:Zfp605
|
UTSW |
5 |
110,276,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3981:Zfp605
|
UTSW |
5 |
110,275,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4095:Zfp605
|
UTSW |
5 |
110,275,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4349:Zfp605
|
UTSW |
5 |
110,276,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Zfp605
|
UTSW |
5 |
110,275,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4914:Zfp605
|
UTSW |
5 |
110,275,567 (GRCm39) |
nonsense |
probably null |
|
|
R4994:Zfp605
|
UTSW |
5 |
110,275,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6672:Zfp605
|
UTSW |
5 |
110,275,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6814:Zfp605
|
UTSW |
5 |
110,275,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6872:Zfp605
|
UTSW |
5 |
110,275,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7251:Zfp605
|
UTSW |
5 |
110,275,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7395:Zfp605
|
UTSW |
5 |
110,259,885 (GRCm39) |
start gained |
probably benign |
|
|
R7560:Zfp605
|
UTSW |
5 |
110,275,157 (GRCm39) |
nonsense |
probably null |
|
|
R7623:Zfp605
|
UTSW |
5 |
110,275,386 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7965:Zfp605
|
UTSW |
5 |
110,275,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7999:Zfp605
|
UTSW |
5 |
110,276,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8307:Zfp605
|
UTSW |
5 |
110,276,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8355:Zfp605
|
UTSW |
5 |
110,259,848 (GRCm39) |
start gained |
probably benign |
|
|
R8455:Zfp605
|
UTSW |
5 |
110,259,848 (GRCm39) |
start gained |
probably benign |
|
|
X0063:Zfp605
|
UTSW |
5 |
110,271,714 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGTTATGGCTTTGAAGAAGTCTTTT -3'
(R):5'- TGATAAGGTGTGACTTCTTGTTGAA -3'
Sequencing Primer
(F):5'- ACATTCCCTGGAAGGTCATCG -3'
(R):5'- AAGTATAAGGTCTCTCTCCCGTATGG -3'
|
| Posted On |
2015-03-18 |
Incidental Mutation