Incidental Mutation 'R3742:Zfp605'
| ID |
270409 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp605
|
| Ensembl Gene |
ENSMUSG00000023284 |
| Gene Name |
zinc finger protein 605 |
| Synonyms |
A830023I12Rik |
| MMRRC Submission |
040728-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R3742 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
110257958-110277660 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 110276564 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Tryptophan
at position 561
(G561W)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108147
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086686]
[ENSMUST00000112528]
[ENSMUST00000147631]
|
| AlphaFold |
E9QAH2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000086686
AA Change: G561W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000083891
Gene: ENSMUSG00000023284
AA Change: G561W
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
66 |
3.75e-28 |
SMART |
|
low complexity region
|
147 |
159 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
200 |
222 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
4.99e1 |
SMART |
|
ZnF_C2H2
|
443 |
465 |
5.4e1 |
SMART |
|
ZnF_C2H2
|
471 |
493 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
499 |
521 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
527 |
549 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
555 |
577 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
583 |
605 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
611 |
633 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
639 |
661 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
667 |
689 |
2.09e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112528
AA Change: G561W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108147
Gene: ENSMUSG00000023284
AA Change: G561W
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
66 |
3.75e-28 |
SMART |
|
low complexity region
|
147 |
159 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
200 |
222 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
4.99e1 |
SMART |
|
ZnF_C2H2
|
443 |
465 |
5.4e1 |
SMART |
|
ZnF_C2H2
|
471 |
493 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
499 |
521 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
527 |
549 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
555 |
577 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
583 |
605 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
611 |
633 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
639 |
661 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
667 |
689 |
2.09e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144089
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147631
|
| SMART Domains |
Protein: ENSMUSP00000122236
Gene: ENSMUSG00000023284
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
66 |
3.75e-28 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
97% (32/33) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp8b2 |
C |
G |
3: 89,853,338 (GRCm39) |
A726P |
probably benign |
Het |
| B4galt3 |
C |
A |
1: 171,101,613 (GRCm39) |
H196N |
probably damaging |
Het |
| Bclaf3 |
T |
A |
X: 158,334,828 (GRCm39) |
H41Q |
probably benign |
Het |
| Bsn |
C |
A |
9: 107,982,938 (GRCm39) |
R3605M |
unknown |
Het |
| Ctso |
G |
A |
3: 81,859,556 (GRCm39) |
V288I |
probably benign |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dnah11 |
A |
G |
12: 118,095,076 (GRCm39) |
M718T |
probably benign |
Het |
| Dsg4 |
A |
T |
18: 20,604,058 (GRCm39) |
T842S |
probably damaging |
Het |
| Epb41l5 |
T |
C |
1: 119,532,973 (GRCm39) |
Q388R |
probably benign |
Het |
| Fbxo6 |
A |
G |
4: 148,234,090 (GRCm39) |
|
probably benign |
Het |
| Frem1 |
A |
C |
4: 82,930,104 (GRCm39) |
Y281D |
probably damaging |
Het |
| Gm6489 |
T |
A |
1: 31,326,764 (GRCm39) |
|
noncoding transcript |
Het |
| Gtpbp2 |
A |
G |
17: 46,476,808 (GRCm39) |
T329A |
probably benign |
Het |
| Hemgn |
T |
C |
4: 46,396,421 (GRCm39) |
T272A |
possibly damaging |
Het |
| Hinfp |
A |
G |
9: 44,213,812 (GRCm39) |
C22R |
probably damaging |
Het |
| Hoxc13 |
G |
A |
15: 102,829,873 (GRCm39) |
G84D |
possibly damaging |
Het |
| Ing5 |
T |
A |
1: 93,740,398 (GRCm39) |
S106R |
probably damaging |
Het |
| Mbd6 |
G |
A |
10: 127,120,812 (GRCm39) |
|
probably benign |
Het |
| Nsf |
C |
T |
11: 103,821,578 (GRCm39) |
E26K |
possibly damaging |
Het |
| Nup210l |
A |
T |
3: 90,114,701 (GRCm39) |
M1759L |
probably benign |
Het |
| Or10ag52 |
A |
G |
2: 87,043,340 (GRCm39) |
I35V |
probably benign |
Het |
| Or5b106 |
A |
G |
19: 13,123,258 (GRCm39) |
F255S |
probably damaging |
Het |
| Or7e168 |
A |
T |
9: 19,720,195 (GRCm39) |
I194F |
probably benign |
Het |
| Or7g25 |
A |
G |
9: 19,159,979 (GRCm39) |
S239P |
possibly damaging |
Het |
| Pde4d |
T |
G |
13: 109,877,013 (GRCm39) |
V53G |
probably benign |
Het |
| Shisa9 |
G |
A |
16: 12,085,528 (GRCm39) |
R379Q |
probably damaging |
Het |
| Syngr4 |
T |
C |
7: 45,545,194 (GRCm39) |
E5G |
possibly damaging |
Het |
| Tiam2 |
A |
G |
17: 3,464,388 (GRCm39) |
D39G |
possibly damaging |
Het |
| Tmem88b |
A |
G |
4: 155,869,884 (GRCm39) |
L59P |
probably damaging |
Het |
| Zfp386 |
T |
A |
12: 116,023,170 (GRCm39) |
L296* |
probably null |
Het |
|
| Other mutations in Zfp605 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02388:Zfp605
|
APN |
5 |
110,275,506 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0010:Zfp605
|
UTSW |
5 |
110,275,400 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0357:Zfp605
|
UTSW |
5 |
110,272,245 (GRCm39) |
missense |
probably benign |
|
|
R0383:Zfp605
|
UTSW |
5 |
110,276,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1017:Zfp605
|
UTSW |
5 |
110,275,860 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1663:Zfp605
|
UTSW |
5 |
110,275,451 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1688:Zfp605
|
UTSW |
5 |
110,276,907 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1752:Zfp605
|
UTSW |
5 |
110,271,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Zfp605
|
UTSW |
5 |
110,275,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2173:Zfp605
|
UTSW |
5 |
110,275,323 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3740:Zfp605
|
UTSW |
5 |
110,276,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3981:Zfp605
|
UTSW |
5 |
110,275,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4095:Zfp605
|
UTSW |
5 |
110,275,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4349:Zfp605
|
UTSW |
5 |
110,276,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Zfp605
|
UTSW |
5 |
110,275,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4914:Zfp605
|
UTSW |
5 |
110,275,567 (GRCm39) |
nonsense |
probably null |
|
|
R4994:Zfp605
|
UTSW |
5 |
110,275,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6672:Zfp605
|
UTSW |
5 |
110,275,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6814:Zfp605
|
UTSW |
5 |
110,275,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6872:Zfp605
|
UTSW |
5 |
110,275,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7251:Zfp605
|
UTSW |
5 |
110,275,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7395:Zfp605
|
UTSW |
5 |
110,259,885 (GRCm39) |
start gained |
probably benign |
|
|
R7560:Zfp605
|
UTSW |
5 |
110,275,157 (GRCm39) |
nonsense |
probably null |
|
|
R7623:Zfp605
|
UTSW |
5 |
110,275,386 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7965:Zfp605
|
UTSW |
5 |
110,275,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7999:Zfp605
|
UTSW |
5 |
110,276,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8307:Zfp605
|
UTSW |
5 |
110,276,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8355:Zfp605
|
UTSW |
5 |
110,259,848 (GRCm39) |
start gained |
probably benign |
|
|
R8455:Zfp605
|
UTSW |
5 |
110,259,848 (GRCm39) |
start gained |
probably benign |
|
|
X0063:Zfp605
|
UTSW |
5 |
110,271,714 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAATGTTATGGCTTTGAAGAAGTCT -3'
(R):5'- TGATAAGGTGTGACTTCTTGTTGAA -3'
Sequencing Primer
(F):5'- ACATTCCCTGGAAGGTCATCG -3'
(R):5'- AAGTATAAGGTCTCTCTCCCGTATGG -3'
|
| Posted On |
2015-03-18 |
Incidental Mutation