Incidental Mutation 'R3760:Taf13'
ID 270496
Institutional Source Beutler Lab
Gene Symbol Taf13
Ensembl Gene ENSMUSG00000048100
Gene Name TATA-box binding protein associated factor 13
Synonyms 1810004N01Rik, 2010309N11Rik
MMRRC Submission 040740-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3760 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 108479015-108489384 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 108485424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143054]
AlphaFold P61216
Predicted Effect noncoding transcript
Transcript: ENSMUST00000056292
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131814
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139603
Predicted Effect probably benign
Transcript: ENSMUST00000143054
SMART Domains Protein: ENSMUSP00000121346
Gene: ENSMUSG00000048100

DomainStartEndE-ValueType
low complexity region 4 26 N/A INTRINSIC
Pfam:TFIID-18kDa 30 119 1.6e-41 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl2 T C 3: 148,522,871 (GRCm39) E1448G probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Ct45a C T X: 55,590,568 (GRCm39) V78I probably benign Het
Ell2 A T 13: 75,910,281 (GRCm39) Q163L probably benign Het
Epha6 T A 16: 60,041,347 (GRCm39) T423S possibly damaging Het
Fhad1 T C 4: 141,637,124 (GRCm39) E1114G probably damaging Het
Gpr83 A T 9: 14,772,034 (GRCm39) T69S probably benign Het
Gramd1c A T 16: 43,818,154 (GRCm39) M342K probably damaging Het
H3c7 T C 13: 23,728,985 (GRCm39) C111R probably damaging Het
Idua T C 5: 108,817,978 (GRCm39) probably benign Het
Kcnh1 T C 1: 192,188,332 (GRCm39) L931P probably damaging Het
Map2 T A 1: 66,478,077 (GRCm39) S470T probably damaging Het
Map7 T C 10: 20,152,027 (GRCm39) probably benign Het
Obscn A G 11: 58,919,406 (GRCm39) L6213P probably damaging Het
Or5b109 T C 19: 13,212,250 (GRCm39) L212P probably damaging Het
Or8k38 G A 2: 86,488,232 (GRCm39) S190L possibly damaging Het
Pcnx4 C T 12: 72,613,780 (GRCm39) T575M probably damaging Het
Ppp1r12a A G 10: 108,100,595 (GRCm39) D348G probably damaging Het
Prrc2c T C 1: 162,520,420 (GRCm39) N730S probably damaging Het
Serpinb3d C T 1: 107,009,304 (GRCm39) probably benign Het
Skint6 T C 4: 112,794,655 (GRCm39) T705A possibly damaging Het
Slc6a20a A G 9: 123,492,054 (GRCm39) I50T probably damaging Het
Tlr11 A T 14: 50,599,700 (GRCm39) E562V probably damaging Het
Uhrf2 T C 19: 30,051,331 (GRCm39) S302P probably benign Het
Ulk1 C T 5: 110,937,223 (GRCm39) R691Q probably benign Het
Unc79 T A 12: 103,058,964 (GRCm39) L1036Q probably damaging Het
Vmn1r85 A T 7: 12,818,932 (GRCm39) S71T probably damaging Het
Vmn2r-ps158 G A 7: 42,673,502 (GRCm39) E187K probably benign Het
Vps52 T C 17: 34,179,162 (GRCm39) F200L possibly damaging Het
Zfp521 T C 18: 13,977,686 (GRCm39) H909R possibly damaging Het
Other mutations in Taf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02886:Taf13 APN 3 108,488,500 (GRCm39) utr 3 prime probably benign
R0302:Taf13 UTSW 3 108,479,038 (GRCm39) start codon destroyed probably null
R1712:Taf13 UTSW 3 108,488,445 (GRCm39) missense possibly damaging 0.92
R4660:Taf13 UTSW 3 108,480,293 (GRCm39) intron probably benign
R5195:Taf13 UTSW 3 108,488,390 (GRCm39) missense probably damaging 1.00
R6001:Taf13 UTSW 3 108,488,387 (GRCm39) missense probably damaging 1.00
R8738:Taf13 UTSW 3 108,485,444 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCATATGTGTGTATGTGTGCATA -3'
(R):5'- AGTGTTGTCTAAAGGTTACACTTCAA -3'

Sequencing Primer
(F):5'- TTACTGCATAGACCAGCCTGG -3'
(R):5'- GCGTCTTACCATTTCAGTGA -3'
Posted On 2015-03-18