Incidental Mutation 'R3760:Gpr83'
ID 270505
Institutional Source Beutler Lab
Gene Symbol Gpr83
Ensembl Gene ENSMUSG00000031932
Gene Name G protein-coupled receptor 83
Synonyms RP39, glucocorticoid-induced receptor, GIR, Gir, Gpr72, RP105, RP82
MMRRC Submission 040740-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R3760 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 14771506-14782085 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 14772034 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 69 (T69S)
Ref Sequence ENSEMBL: ENSMUSP00000111287 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034408] [ENSMUST00000115624]
AlphaFold P30731
Predicted Effect probably benign
Transcript: ENSMUST00000034408
AA Change: T69S

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000034408
Gene: ENSMUSG00000031932
AA Change: T69S

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:7tm_4 78 271 2.4e-8 PFAM
Pfam:7TM_GPCR_Srsx 82 360 6.6e-16 PFAM
Pfam:7tm_1 88 345 9e-52 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115624
AA Change: T69S

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000111287
Gene: ENSMUSG00000031932
AA Change: T69S

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:7tm_1 88 133 1.1e-10 PFAM
Pfam:7TM_GPCR_Srsx 128 318 1.8e-6 PFAM
Pfam:7tm_1 129 303 1.4e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133278
Meta Mutation Damage Score 0.0631 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (33/33)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit normal regulatory T cell development. Mice homozygous for a different targeted allele exhibit attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl2 T C 3: 148,522,871 (GRCm39) E1448G probably damaging Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Ct45a C T X: 55,590,568 (GRCm39) V78I probably benign Het
Ell2 A T 13: 75,910,281 (GRCm39) Q163L probably benign Het
Epha6 T A 16: 60,041,347 (GRCm39) T423S possibly damaging Het
Fhad1 T C 4: 141,637,124 (GRCm39) E1114G probably damaging Het
Gramd1c A T 16: 43,818,154 (GRCm39) M342K probably damaging Het
H3c7 T C 13: 23,728,985 (GRCm39) C111R probably damaging Het
Idua T C 5: 108,817,978 (GRCm39) probably benign Het
Kcnh1 T C 1: 192,188,332 (GRCm39) L931P probably damaging Het
Map2 T A 1: 66,478,077 (GRCm39) S470T probably damaging Het
Map7 T C 10: 20,152,027 (GRCm39) probably benign Het
Obscn A G 11: 58,919,406 (GRCm39) L6213P probably damaging Het
Or5b109 T C 19: 13,212,250 (GRCm39) L212P probably damaging Het
Or8k38 G A 2: 86,488,232 (GRCm39) S190L possibly damaging Het
Pcnx4 C T 12: 72,613,780 (GRCm39) T575M probably damaging Het
Ppp1r12a A G 10: 108,100,595 (GRCm39) D348G probably damaging Het
Prrc2c T C 1: 162,520,420 (GRCm39) N730S probably damaging Het
Serpinb3d C T 1: 107,009,304 (GRCm39) probably benign Het
Skint6 T C 4: 112,794,655 (GRCm39) T705A possibly damaging Het
Slc6a20a A G 9: 123,492,054 (GRCm39) I50T probably damaging Het
Taf13 T C 3: 108,485,424 (GRCm39) probably benign Het
Tlr11 A T 14: 50,599,700 (GRCm39) E562V probably damaging Het
Uhrf2 T C 19: 30,051,331 (GRCm39) S302P probably benign Het
Ulk1 C T 5: 110,937,223 (GRCm39) R691Q probably benign Het
Unc79 T A 12: 103,058,964 (GRCm39) L1036Q probably damaging Het
Vmn1r85 A T 7: 12,818,932 (GRCm39) S71T probably damaging Het
Vmn2r-ps158 G A 7: 42,673,502 (GRCm39) E187K probably benign Het
Vps52 T C 17: 34,179,162 (GRCm39) F200L possibly damaging Het
Zfp521 T C 18: 13,977,686 (GRCm39) H909R possibly damaging Het
Other mutations in Gpr83
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00579:Gpr83 APN 9 14,771,897 (GRCm39) missense probably benign 0.00
bland UTSW 9 14,778,279 (GRCm39) critical splice donor site probably null
R0243:Gpr83 UTSW 9 14,776,138 (GRCm39) missense possibly damaging 0.96
R0349:Gpr83 UTSW 9 14,779,563 (GRCm39) missense probably damaging 1.00
R0731:Gpr83 UTSW 9 14,779,940 (GRCm39) missense probably benign 0.00
R1519:Gpr83 UTSW 9 14,779,493 (GRCm39) missense probably null 1.00
R1678:Gpr83 UTSW 9 14,778,145 (GRCm39) missense probably damaging 1.00
R1826:Gpr83 UTSW 9 14,779,629 (GRCm39) missense possibly damaging 0.53
R1827:Gpr83 UTSW 9 14,779,629 (GRCm39) missense possibly damaging 0.53
R1828:Gpr83 UTSW 9 14,779,629 (GRCm39) missense possibly damaging 0.53
R2938:Gpr83 UTSW 9 14,776,167 (GRCm39) missense probably benign 0.23
R4038:Gpr83 UTSW 9 14,772,073 (GRCm39) missense possibly damaging 0.77
R4438:Gpr83 UTSW 9 14,776,134 (GRCm39) missense probably damaging 0.99
R4657:Gpr83 UTSW 9 14,778,279 (GRCm39) critical splice donor site probably null
R4731:Gpr83 UTSW 9 14,777,470 (GRCm39) intron probably benign
R5150:Gpr83 UTSW 9 14,772,101 (GRCm39) missense probably damaging 1.00
R7770:Gpr83 UTSW 9 14,778,170 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGTGCCTAGAGCTGCAGTG -3'
(R):5'- CGTGTTGAGCAATGTGATCATG -3'

Sequencing Primer
(F):5'- GCTGGACATGAAGGTTCCTC -3'
(R):5'- AATGTGATCATGATGTCCGCCAC -3'
Posted On 2015-03-18