Incidental Mutation 'IGL00769:Pglyrp3'
ID27055
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp3
Ensembl Gene ENSMUSG00000042244
Gene Namepeptidoglycan recognition protein 3
SynonymsLOC242100
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.188) question?
Stock #IGL00769
Quality Score
Status
Chromosome3
Chromosomal Location92014583-92031582 bp(+) (GRCm38)
Type of Mutationutr 5 prime
DNA Base Change (assembly) A to T at 92014622 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000035737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047660]
Predicted Effect probably benign
Transcript: ENSMUST00000047660
SMART Domains Protein: ENSMUSP00000035737
Gene: ENSMUSG00000042244

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
PGRP 28 169 2.64e-45 SMART
Ami_2 39 169 1.06e-2 SMART
PGRP 185 326 3.23e-72 SMART
Ami_2 195 332 1.75e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103897
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001P01Rik A G 11: 97,771,581 F155S probably damaging Het
9930111J21Rik1 A G 11: 48,948,212 V516A possibly damaging Het
A730017C20Rik T C 18: 59,072,277 S88P probably damaging Het
Ambp G A 4: 63,144,165 T279I probably damaging Het
Ankrd28 A G 14: 31,743,365 V285A possibly damaging Het
Arfgef3 A G 10: 18,660,604 S220P probably benign Het
Atp9b G T 18: 80,912,853 H129N probably benign Het
Cdh10 C A 15: 18,985,099 P283Q possibly damaging Het
Cep295 A G 9: 15,326,144 S1941P probably damaging Het
Dmbt1 T A 7: 131,082,500 S575R probably damaging Het
Dock11 A G X: 36,004,062 N796S possibly damaging Het
Enam A T 5: 88,501,484 Y284F possibly damaging Het
F8 A T X: 75,334,180 probably benign Het
Fbxo42 C T 4: 141,180,449 T140M probably damaging Het
Galnt13 G A 2: 54,880,104 E303K probably benign Het
Mrgprb4 T A 7: 48,198,901 D93V probably benign Het
Msl3 T A X: 168,668,748 E215V probably damaging Het
Prdx1 G A 4: 116,692,965 D115N probably benign Het
Psd3 A T 8: 67,908,679 probably benign Het
Rundc1 A G 11: 101,434,274 D602G probably damaging Het
Slc4a1ap T G 5: 31,553,777 Y742D probably damaging Het
Ugt1a6a C T 1: 88,139,050 P193S probably damaging Het
Vmn2r96 G A 17: 18,583,819 V252M probably benign Het
Wdr53 G A 16: 32,256,497 W173* probably null Het
Other mutations in Pglyrp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Pglyrp3 APN 3 92022679 missense probably damaging 0.96
IGL02491:Pglyrp3 APN 3 92014637 missense possibly damaging 0.77
IGL03279:Pglyrp3 APN 3 92026527 missense probably damaging 1.00
R0056:Pglyrp3 UTSW 3 92025804 splice site probably benign
R1128:Pglyrp3 UTSW 3 92028172 missense probably benign 0.22
R2097:Pglyrp3 UTSW 3 92028171 missense possibly damaging 0.91
R2140:Pglyrp3 UTSW 3 92026567 missense probably benign 0.00
R3697:Pglyrp3 UTSW 3 92028174 missense probably damaging 1.00
R4369:Pglyrp3 UTSW 3 92028079 missense probably damaging 1.00
R4430:Pglyrp3 UTSW 3 92031491 missense probably damaging 1.00
R4775:Pglyrp3 UTSW 3 92025730 missense possibly damaging 0.64
R6020:Pglyrp3 UTSW 3 92031534 missense probably damaging 1.00
R7352:Pglyrp3 UTSW 3 92014640 nonsense probably null
R7437:Pglyrp3 UTSW 3 92030678 missense probably benign 0.00
R8150:Pglyrp3 UTSW 3 92026483 missense probably benign 0.00
R8466:Pglyrp3 UTSW 3 92014634 missense probably benign 0.16
R8695:Pglyrp3 UTSW 3 92026455 missense probably null 1.00
Z1176:Pglyrp3 UTSW 3 92028085 missense probably damaging 1.00
Posted On2013-04-17