Incidental Mutation 'R3723:Vmn1r117'
ID270627
Institutional Source Beutler Lab
Gene Symbol Vmn1r117
Ensembl Gene ENSMUSG00000096737
Gene Namevomeronasal 1 receptor 117
SynonymsGm8544
MMRRC Submission 040714-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #R3723 (G1)
Quality Score169
Status Not validated
Chromosome7
Chromosomal Location20883198-20884121 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 20883455 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 223 (I223F)
Ref Sequence ENSEMBL: ENSMUSP00000131580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166937]
Predicted Effect probably damaging
Transcript: ENSMUST00000166937
AA Change: I223F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000131580
Gene: ENSMUSG00000096737
AA Change: I223F

DomainStartEndE-ValueType
Pfam:TAS2R 8 298 1.3e-15 PFAM
Pfam:7tm_1 31 290 3.9e-6 PFAM
Pfam:V1R 41 298 6.4e-17 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 95% (38/40)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T C 19: 9,016,853 V5167A possibly damaging Het
Ano5 A G 7: 51,576,528 Y510C probably damaging Het
Api5 C T 2: 94,425,613 R243Q possibly damaging Het
Apob A T 12: 8,006,327 Q1570L probably damaging Het
Apob A G 12: 8,011,763 N3415S possibly damaging Het
Arsk T A 13: 76,066,653 I361F probably damaging Het
C9 G A 15: 6,483,080 E228K possibly damaging Het
Celsr2 A G 3: 108,397,415 probably benign Het
Cfap53 A G 18: 74,359,569 I455V probably benign Het
Ckap4 A G 10: 84,528,392 L269P probably damaging Het
Dnah7a T A 1: 53,447,346 D3352V probably benign Het
Dync2h1 A T 9: 7,041,658 M3335K probably benign Het
Fam171a1 A G 2: 3,220,375 probably benign Het
Glis3 A T 19: 28,262,591 C97* probably null Het
Gm13101 T C 4: 143,966,681 T76A probably benign Het
Gm14221 C G 2: 160,568,427 noncoding transcript Het
Gm8603 A C 17: 13,516,813 probably null Het
Gm9767 G T 10: 26,078,571 probably benign Het
Kctd16 A G 18: 40,258,859 T167A possibly damaging Het
Kif18b A G 11: 102,916,276 F78L probably damaging Het
Mefv A G 16: 3,708,194 probably null Het
Mipol1 C A 12: 57,457,092 L349I probably damaging Het
Myo10 T C 15: 25,803,288 V1527A probably damaging Het
Naip5 G T 13: 100,223,014 Y571* probably null Het
Npl A G 1: 153,515,464 F182L probably benign Het
Pan3 T A 5: 147,503,208 probably benign Het
Pcdh15 A T 10: 74,645,848 T342S probably benign Het
Pcdhga1 A G 18: 37,662,992 T350A possibly damaging Het
Prdm4 A G 10: 85,899,281 S666P probably damaging Het
Rere A G 4: 150,468,795 E148G probably damaging Het
Scube2 T C 7: 109,808,406 probably benign Het
Sptbn1 A G 11: 30,137,335 S1035P possibly damaging Het
Srsf4 C T 4: 131,900,102 probably benign Het
Supt3 A G 17: 44,994,387 D108G probably damaging Het
Tnfsf13b A G 8: 10,031,545 I236V possibly damaging Het
Tns1 T C 1: 73,924,940 S1511G probably damaging Het
Tpm1 G A 9: 67,031,945 probably benign Het
Uba6 T C 5: 86,135,047 D559G probably damaging Het
Vmn2r91 G A 17: 18,085,278 probably null Het
Zfp30 A G 7: 29,793,353 E344G probably damaging Het
Other mutations in Vmn1r117
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4519001:Vmn1r117 UTSW 7 20883235 missense possibly damaging 0.83
R0480:Vmn1r117 UTSW 7 20883446 missense probably benign 0.05
R1582:Vmn1r117 UTSW 7 20883559 missense possibly damaging 0.67
R4552:Vmn1r117 UTSW 7 20883592 missense probably damaging 0.99
R4553:Vmn1r117 UTSW 7 20883592 missense probably damaging 0.99
R4888:Vmn1r117 UTSW 7 20883496 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTCACTGACAAGCCTTACG -3'
(R):5'- GTGTCACAAACATGGCAAGTTATTC -3'

Sequencing Primer
(F):5'- CTGACAAGCCTTACGAAGAAATG -3'
(R):5'- CCAATTAAGTTCAGTGGTCCACAG -3'
Posted On2015-03-18