Mutagenetix > Incidental Mutations

Incidental Mutation 'R3723:Vmn2r91'

270647

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r91

Ensembl Gene

ENSMUSG00000091206

Gene Name

vomeronasal 2, receptor 91

Synonyms

EG665210

MMRRC Submission

040714-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R3723 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18085057-18136643 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 18085278 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172359]

AlphaFold

E9Q2U5

Predicted Effect

probably null
Transcript: ENSMUST00000172359

SMART Domains

Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	462	2.2e-38	PFAM
Pfam:NCD3G	510	564	6.7e-20	PFAM
Pfam:7tm_3	597	832	2.1e-53	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

95% (38/40)

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	T	C	19: 9,016,853	V5167A	possibly damaging	Het
Ano5	A	G	7: 51,576,528	Y510C	probably damaging	Het
Api5	C	T	2: 94,425,613	R243Q	possibly damaging	Het
Apob	A	G	12: 8,011,763	N3415S	possibly damaging	Het
Apob	A	T	12: 8,006,327	Q1570L	probably damaging	Het
Arsk	T	A	13: 76,066,653	I361F	probably damaging	Het
C9	G	A	15: 6,483,080	E228K	possibly damaging	Het
Celsr2	A	G	3: 108,397,415		probably benign	Het
Cfap53	A	G	18: 74,359,569	I455V	probably benign	Het
Ckap4	A	G	10: 84,528,392	L269P	probably damaging	Het
Dnah7a	T	A	1: 53,447,346	D3352V	probably benign	Het
Dync2h1	A	T	9: 7,041,658	M3335K	probably benign	Het
Fam171a1	A	G	2: 3,220,375		probably benign	Het
Glis3	A	T	19: 28,262,591	C97*	probably null	Het
Gm13101	T	C	4: 143,966,681	T76A	probably benign	Het
Gm14221	C	G	2: 160,568,427		noncoding transcript	Het
Gm8603	A	C	17: 13,516,813		probably null	Het
Gm9767	G	T	10: 26,078,571		probably benign	Het
Kctd16	A	G	18: 40,258,859	T167A	possibly damaging	Het
Kif18b	A	G	11: 102,916,276	F78L	probably damaging	Het
Mefv	A	G	16: 3,708,194		probably null	Het
Mipol1	C	A	12: 57,457,092	L349I	probably damaging	Het
Myo10	T	C	15: 25,803,288	V1527A	probably damaging	Het
Naip5	G	T	13: 100,223,014	Y571*	probably null	Het
Npl	A	G	1: 153,515,464	F182L	probably benign	Het
Pan3	T	A	5: 147,503,208		probably benign	Het
Pcdh15	A	T	10: 74,645,848	T342S	probably benign	Het
Pcdhga1	A	G	18: 37,662,992	T350A	possibly damaging	Het
Prdm4	A	G	10: 85,899,281	S666P	probably damaging	Het
Rere	A	G	4: 150,468,795	E148G	probably damaging	Het
Scube2	T	C	7: 109,808,406		probably benign	Het
Sptbn1	A	G	11: 30,137,335	S1035P	possibly damaging	Het
Srsf4	C	T	4: 131,900,102		probably benign	Het
Supt3	A	G	17: 44,994,387	D108G	probably damaging	Het
Tnfsf13b	A	G	8: 10,031,545	I236V	possibly damaging	Het
Tns1	T	C	1: 73,924,940	S1511G	probably damaging	Het
Tpm1	G	A	9: 67,031,945		probably benign	Het
Uba6	T	C	5: 86,135,047	D559G	probably damaging	Het
Vmn1r117	T	A	7: 20,883,455	I223F	probably damaging	Het
Zfp30	A	G	7: 29,793,353	E344G	probably damaging	Het

Other mutations in Vmn2r91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Vmn2r91	APN	17	18105558	missense	probably benign	0.00
IGL01121:Vmn2r91	APN	17	18136504	missense	possibly damaging	0.94
IGL01464:Vmn2r91	APN	17	18107602	missense	probably null	0.00
IGL02003:Vmn2r91	APN	17	18107659	missense	probably benign
IGL02709:Vmn2r91	APN	17	18105449	missense	possibly damaging	0.74
IGL02795:Vmn2r91	APN	17	18085277	missense	probably benign	0.01
IGL02813:Vmn2r91	APN	17	18136086	missense	possibly damaging	0.91
IGL02830:Vmn2r91	APN	17	18136622	missense	probably benign	0.01
IGL03130:Vmn2r91	APN	17	18110111	splice site	probably benign
BB006:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
BB016:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R0164:Vmn2r91	UTSW	17	18106137	missense	probably benign	0.00
R0164:Vmn2r91	UTSW	17	18106137	missense	probably benign	0.00
R0393:Vmn2r91	UTSW	17	18105450	missense	probably damaging	1.00
R1142:Vmn2r91	UTSW	17	18136443	missense	probably damaging	1.00
R1603:Vmn2r91	UTSW	17	18106143	missense	probably benign	0.04
R1992:Vmn2r91	UTSW	17	18135880	missense	probably damaging	1.00
R2182:Vmn2r91	UTSW	17	18105429	missense	possibly damaging	0.94
R2424:Vmn2r91	UTSW	17	18136169	nonsense	probably null
R2512:Vmn2r91	UTSW	17	18135786	missense	probably benign
R2885:Vmn2r91	UTSW	17	18105366	missense	probably benign	0.00
R2909:Vmn2r91	UTSW	17	18136399	missense	probably damaging	1.00
R3009:Vmn2r91	UTSW	17	18105455	missense	probably benign	0.11
R3079:Vmn2r91	UTSW	17	18135711	splice site	probably null
R3080:Vmn2r91	UTSW	17	18135711	splice site	probably null
R3434:Vmn2r91	UTSW	17	18110108	splice site	probably benign
R3829:Vmn2r91	UTSW	17	18105497	missense	probably damaging	1.00
R3845:Vmn2r91	UTSW	17	18107598	missense	probably benign	0.00
R3846:Vmn2r91	UTSW	17	18107598	missense	probably benign	0.00
R4118:Vmn2r91	UTSW	17	18110096	missense	probably damaging	1.00
R4285:Vmn2r91	UTSW	17	18135768	missense	probably benign	0.00
R4729:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R4793:Vmn2r91	UTSW	17	18105396	missense	probably damaging	1.00
R4932:Vmn2r91	UTSW	17	18136489	missense	possibly damaging	0.84
R5016:Vmn2r91	UTSW	17	18110060	nonsense	probably null
R5018:Vmn2r91	UTSW	17	18136438	missense	probably damaging	1.00
R5605:Vmn2r91	UTSW	17	18136501	missense	probably damaging	1.00
R5815:Vmn2r91	UTSW	17	18106202	missense	probably benign	0.01
R6146:Vmn2r91	UTSW	17	18136256	missense	probably benign	0.07
R6187:Vmn2r91	UTSW	17	18106626	missense	probably benign	0.05
R6426:Vmn2r91	UTSW	17	18135603	splice site	probably null
R6450:Vmn2r91	UTSW	17	18085265	missense	probably damaging	0.98
R6767:Vmn2r91	UTSW	17	18107545	missense	probably damaging	0.98
R6986:Vmn2r91	UTSW	17	18136009	missense	probably benign	0.10
R7112:Vmn2r91	UTSW	17	18105618	missense	possibly damaging	0.83
R7178:Vmn2r91	UTSW	17	18136162	missense	probably damaging	1.00
R7330:Vmn2r91	UTSW	17	18106167	missense	probably damaging	1.00
R7368:Vmn2r91	UTSW	17	18136278	missense	possibly damaging	0.75
R7380:Vmn2r91	UTSW	17	18136576	nonsense	probably null
R7397:Vmn2r91	UTSW	17	18135798	missense	probably benign	0.02
R7625:Vmn2r91	UTSW	17	18105431	missense	probably damaging	1.00
R7739:Vmn2r91	UTSW	17	18135818	missense	probably benign	0.00
R7749:Vmn2r91	UTSW	17	18136278	missense	possibly damaging	0.75
R7755:Vmn2r91	UTSW	17	18110049	missense	possibly damaging	0.88
R7929:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R7981:Vmn2r91	UTSW	17	18107625	missense	probably benign	0.02
R8211:Vmn2r91	UTSW	17	18106500	missense	probably damaging	1.00
R8325:Vmn2r91	UTSW	17	18136363	missense	probably damaging	1.00
R8781:Vmn2r91	UTSW	17	18085061	missense	possibly damaging	0.78
R8974:Vmn2r91	UTSW	17	18105374	missense	probably benign	0.27
R9047:Vmn2r91	UTSW	17	18106034	missense	probably benign	0.00
R9048:Vmn2r91	UTSW	17	18135860	missense	probably benign	0.00
R9109:Vmn2r91	UTSW	17	18107643	missense	probably damaging	1.00
R9211:Vmn2r91	UTSW	17	18136557	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- ACCAAGCATACATGTACTGGAC -3'
(R):5'- GGTGAGTACCTCCAAATCACC -3'

Sequencing Primer
(F):5'- GGCTCTTGCAAGTTCCAAAATTTTTC -3'
(R):5'- ATTGCGGCATAATAAGAATAGCC -3'

Posted On

2015-03-18