Incidental Mutation 'IGL00927:Dcun1d1'
ID27102
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcun1d1
Ensembl Gene ENSMUSG00000027708
Gene NameDCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
SynonymsSCCRO, Tes3, Rp42, pTes3
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.536) question?
Stock #IGL00927
Quality Score
Status
Chromosome3
Chromosomal Location35892105-35937445 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 35920965 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143716 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108182] [ENSMUST00000148465] [ENSMUST00000178098] [ENSMUST00000196270] [ENSMUST00000197489] [ENSMUST00000198362] [ENSMUST00000198389] [ENSMUST00000199173] [ENSMUST00000200661]
Predicted Effect probably benign
Transcript: ENSMUST00000108182
SMART Domains Protein: ENSMUSP00000103817
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 9 50 1.6e-12 PFAM
Pfam:Cullin_binding 136 247 2.2e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000148465
SMART Domains Protein: ENSMUSP00000115420
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 2.5e-8 PFAM
Pfam:Cullin_binding 119 214 9.4e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178098
SMART Domains Protein: ENSMUSP00000137324
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 3e-8 PFAM
Pfam:Cullin_binding 119 233 6.7e-43 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196115
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196263
Predicted Effect probably benign
Transcript: ENSMUST00000196270
SMART Domains Protein: ENSMUSP00000142384
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 8.8e-9 PFAM
PDB:3TDZ|B 47 115 3e-44 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000197489
SMART Domains Protein: ENSMUSP00000142690
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 9 50 7.5e-11 PFAM
PDB:3TDZ|B 62 89 9e-12 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000197546
Predicted Effect probably benign
Transcript: ENSMUST00000198362
Predicted Effect probably benign
Transcript: ENSMUST00000198389
SMART Domains Protein: ENSMUSP00000143243
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 3e-8 PFAM
Pfam:Cullin_binding 119 233 6.7e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000199173
SMART Domains Protein: ENSMUSP00000142443
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 8.8e-9 PFAM
PDB:3TDZ|B 47 115 3e-44 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000200661
SMART Domains Protein: ENSMUSP00000143716
Gene: ENSMUSG00000027708

DomainStartEndE-ValueType
Pfam:UBA_4 1 35 5e-9 PFAM
Pfam:Cullin_binding 121 220 9.9e-31 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310033P09Rik A G 11: 59,208,848 T92A probably damaging Het
Ankhd1 A G 18: 36,632,072 S1007G probably benign Het
Cabp4 A T 19: 4,139,407 S50R possibly damaging Het
Camp A T 9: 109,849,268 L56Q probably damaging Het
Cblb A G 16: 52,166,098 N568S probably benign Het
Ccr6 C A 17: 8,255,993 T10K probably benign Het
Chit1 T C 1: 134,145,254 F106S probably damaging Het
Cyb561d1 A G 3: 108,199,627 L34P probably damaging Het
Deup1 A G 9: 15,610,671 probably benign Het
Erich1 A G 8: 14,033,518 F184S probably damaging Het
Fmnl3 A G 15: 99,337,628 probably null Het
Grk2 T C 19: 4,287,954 N508S probably benign Het
Herc4 A G 10: 63,273,537 I184V probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Kif3b G A 2: 153,316,461 A61T possibly damaging Het
Kmt2d G A 15: 98,845,009 probably benign Het
Lrrc7 C A 3: 158,161,090 V1005L possibly damaging Het
Lrrtm1 A T 6: 77,244,063 M168L probably benign Het
Ndc1 C T 4: 107,384,780 probably benign Het
Nphs1 A G 7: 30,460,739 probably benign Het
Olfr692 A T 7: 105,369,247 Y298F probably damaging Het
Pbld2 T C 10: 63,071,955 V200A probably benign Het
Pcdhb21 A G 18: 37,514,553 Y245C probably damaging Het
Pcm1 A G 8: 41,287,881 T1055A probably damaging Het
Plcl2 C T 17: 50,606,920 S319L probably benign Het
Plekha8 C A 6: 54,629,837 Y372* probably null Het
Ralb T A 1: 119,471,776 N184I probably benign Het
Robo3 C T 9: 37,427,754 probably null Het
Slc41a1 T A 1: 131,839,176 L144H probably damaging Het
Smg1 C T 7: 118,140,632 G3364D probably damaging Het
Theg A G 10: 79,576,599 S329P probably damaging Het
Ttc26 T C 6: 38,382,220 probably benign Het
Vmn1r123 T A 7: 21,162,291 V36D possibly damaging Het
Zbtb7c T C 18: 76,145,850 S460P possibly damaging Het
Zscan30 T C 18: 23,971,777 noncoding transcript Het
Other mutations in Dcun1d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Dcun1d1 APN 3 35916306 missense possibly damaging 0.80
IGL03092:Dcun1d1 APN 3 35920992 missense possibly damaging 0.88
IGL03214:Dcun1d1 APN 3 35919071 missense probably damaging 1.00
deacon UTSW 3 35897785 splice site probably benign
Preacher UTSW 3 35897791 critical splice donor site probably null
LCD18:Dcun1d1 UTSW 3 35938005 unclassified probably benign
R0575:Dcun1d1 UTSW 3 35897785 splice site probably benign
R1006:Dcun1d1 UTSW 3 35897781 splice site probably benign
R1820:Dcun1d1 UTSW 3 35919004 nonsense probably null
R4714:Dcun1d1 UTSW 3 35895670 missense probably damaging 1.00
R5849:Dcun1d1 UTSW 3 35916184 intron probably benign
R6681:Dcun1d1 UTSW 3 35895670 missense probably damaging 1.00
R7312:Dcun1d1 UTSW 3 35897791 critical splice donor site probably null
X0018:Dcun1d1 UTSW 3 35921144 start codon destroyed probably null 0.99
Posted On2013-04-17