Mutagenetix > Incidental Mutation

Incidental Mutation 'R3744:Vmn2r97'

271139

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

MMRRC Submission

040730-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R3744 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19134584-19168333 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19149890 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 426 (H426R)

Ref Sequence

ENSEMBL: ENSMUSP00000156141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

probably benign
Transcript: ENSMUST00000168710
AA Change: H426R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: H426R

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232219
AA Change: H426R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232325

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.6%

Validation Efficiency

100% (33/33)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg1	T	C	17: 31,330,190 (GRCm39)		probably benign	Het
Aox4	C	T	1: 58,285,029 (GRCm39)	H594Y	probably damaging	Het
Aspn	G	A	13: 49,720,036 (GRCm39)	E351K	probably damaging	Het
BC004004	A	G	17: 29,520,423 (GRCm39)	*349W	probably null	Het
Elmo2	C	T	2: 165,157,922 (GRCm39)	D39N	probably damaging	Het
Fam161a	T	C	11: 22,970,410 (GRCm39)	F196S	probably damaging	Het
Fam186a	A	G	15: 99,845,416 (GRCm39)	V276A	unknown	Het
Fn3krp	T	C	11: 121,317,531 (GRCm39)		probably null	Het
Gnai3	T	C	3: 108,016,714 (GRCm39)		probably benign	Het
Hspg2	C	T	4: 137,292,815 (GRCm39)		probably benign	Het
Igkv5-43	G	A	6: 69,752,921 (GRCm39)	H54Y	probably benign	Het
Kif26b	A	G	1: 178,506,595 (GRCm39)	I224V	probably benign	Het
Lyg1	T	C	1: 37,988,923 (GRCm39)	Y99C	probably benign	Het
Myh4	C	T	11: 67,146,141 (GRCm39)	R1400C	probably damaging	Het
Nf1	T	C	11: 79,439,573 (GRCm39)	S2262P	probably benign	Het
Pop5	T	C	5: 115,378,567 (GRCm39)	Y117H	possibly damaging	Het
Prpf8	T	A	11: 75,397,547 (GRCm39)		probably null	Het
Ptch1	T	G	13: 63,672,773 (GRCm39)	E944A	probably benign	Het
Rapgef6	T	C	11: 54,516,760 (GRCm39)	F54S	probably benign	Het
Sptb	T	C	12: 76,647,174 (GRCm39)	T1954A	probably benign	Het
Ssbp2	T	C	13: 91,828,765 (GRCm39)		probably benign	Het
Tap1	A	T	17: 34,412,586 (GRCm39)	D541V	probably damaging	Het
Tcte1	A	G	17: 45,850,597 (GRCm39)	D291G	probably damaging	Het
Tpbg	A	G	9: 85,727,215 (GRCm39)	R395G	probably damaging	Het
Trappc10	T	A	10: 78,034,924 (GRCm39)	S941C	probably benign	Het
Usp19	G	A	9: 108,377,380 (GRCm39)	R886Q	probably damaging	Het
Utp14b	G	T	1: 78,642,973 (GRCm39)	E290D	probably benign	Het
Vmn1r30	A	T	6: 58,412,804 (GRCm39)	Y9*	probably null	Het
Vwa3a	A	G	7: 120,351,817 (GRCm39)	D27G	probably benign	Het
Zfp36	A	G	7: 28,077,201 (GRCm39)	S236P	probably benign	Het
Zfp616	C	A	11: 73,974,813 (GRCm39)	H452N	probably benign	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	19,167,921 (GRCm39)	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	19,149,490 (GRCm39)	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	19,168,073 (GRCm39)	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	19,149,286 (GRCm39)	nonsense	probably null
IGL02429:Vmn2r97	APN	17	19,150,596 (GRCm39)	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	19,149,432 (GRCm39)	missense	probably damaging	0.97
IGL02934:Vmn2r97	APN	17	19,149,947 (GRCm39)	missense	probably benign	0.00
IGL02978:Vmn2r97	APN	17	19,168,298 (GRCm39)	missense	probably benign	0.01
IGL03230:Vmn2r97	APN	17	19,149,668 (GRCm39)	missense	probably benign	0.10
IGL03241:Vmn2r97	APN	17	19,148,438 (GRCm39)	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	19,167,900 (GRCm39)	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	19,149,878 (GRCm39)	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	19,167,930 (GRCm39)	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	19,134,734 (GRCm39)	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	19,167,665 (GRCm39)	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	19,148,440 (GRCm39)	nonsense	probably null
R1546:Vmn2r97	UTSW	17	19,168,110 (GRCm39)	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	19,149,397 (GRCm39)	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	19,167,648 (GRCm39)	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	19,149,593 (GRCm39)	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	19,160,500 (GRCm39)	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	19,149,944 (GRCm39)	missense	unknown
R2106:Vmn2r97	UTSW	17	19,168,100 (GRCm39)	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2153:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2154:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2516:Vmn2r97	UTSW	17	19,167,814 (GRCm39)	missense	probably benign
R3739:Vmn2r97	UTSW	17	19,148,413 (GRCm39)	missense	probably damaging	1.00
R3885:Vmn2r97	UTSW	17	19,148,596 (GRCm39)	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	19,167,873 (GRCm39)	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	19,148,332 (GRCm39)	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	19,167,542 (GRCm39)	missense	possibly damaging	0.83
R4287:Vmn2r97	UTSW	17	19,168,337 (GRCm39)	intron	probably benign
R4439:Vmn2r97	UTSW	17	19,150,616 (GRCm39)	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	19,149,550 (GRCm39)	missense	probably benign
R4948:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	19,160,436 (GRCm39)	nonsense	probably null
R5029:Vmn2r97	UTSW	17	19,168,173 (GRCm39)	missense	probably damaging	1.00
R5200:Vmn2r97	UTSW	17	19,148,615 (GRCm39)	missense	probably damaging	1.00
R5541:Vmn2r97	UTSW	17	19,148,617 (GRCm39)	nonsense	probably null
R5637:Vmn2r97	UTSW	17	19,167,628 (GRCm39)	nonsense	probably null
R5765:Vmn2r97	UTSW	17	19,167,442 (GRCm39)	nonsense	probably null
R5885:Vmn2r97	UTSW	17	19,168,035 (GRCm39)	missense	possibly damaging	0.50
R6272:Vmn2r97	UTSW	17	19,167,861 (GRCm39)	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	19,150,566 (GRCm39)	nonsense	probably null
R6818:Vmn2r97	UTSW	17	19,168,193 (GRCm39)	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	19,167,756 (GRCm39)	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	19,134,663 (GRCm39)	missense	probably damaging	1.00
R7044:Vmn2r97	UTSW	17	19,134,629 (GRCm39)	missense	probably benign	0.05
R7191:Vmn2r97	UTSW	17	19,150,548 (GRCm39)	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	19,148,470 (GRCm39)	missense	probably benign
R7862:Vmn2r97	UTSW	17	19,167,416 (GRCm39)	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	19,149,326 (GRCm39)	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	19,149,802 (GRCm39)	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	19,150,662 (GRCm39)	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	19,167,854 (GRCm39)	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	19,134,802 (GRCm39)	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	19,168,104 (GRCm39)	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	19,160,472 (GRCm39)	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	19,149,607 (GRCm39)	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	19,134,585 (GRCm39)	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	19,149,640 (GRCm39)	missense	probably benign
R9252:Vmn2r97	UTSW	17	19,167,849 (GRCm39)	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	19,134,762 (GRCm39)	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	19,149,368 (GRCm39)	missense	probably benign
R9422:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R9496:Vmn2r97	UTSW	17	19,149,227 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r97	UTSW	17	19,149,919 (GRCm39)	missense	probably benign
R9601:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign
R9672:Vmn2r97	UTSW	17	19,149,442 (GRCm39)	missense	probably benign	0.00
R9773:Vmn2r97	UTSW	17	19,168,221 (GRCm39)	missense	probably benign	0.01
R9795:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAAGTGCTCATTTTCTGACAC -3'
(R):5'- ACCTTGCCCATGATTTCAAAAC -3'

Sequencing Primer
(F):5'- AGTGCTCATTTTCTGACACTAATTG -3'
(R):5'- TGCCCATGATTTCAAAACATCATAC -3'

Posted On

2015-03-18