|Institutional Source||Beutler Lab|
|Gene Name||protein phosphatase, EF hand calcium-binding domain 2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3745 (G1)|
|Chromosomal Location||92226679-92256278 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to A at 92239151 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000144157 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031359] [ENSMUST00000201130]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||98% (44/45)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation appear to be phenotypically normal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ppef2||
(F):5'- TTAAAGCCAGAGCCCAGGTG -3'
(R):5'- TATCAGCCTGCCAATTGCGTG -3'
(F):5'- CCAGAGCCCAGGTGAAAAG -3'
(R):5'- ATAAGGGTTGCCATCAAGCTTGTC -3'