Incidental Mutation 'R3751:Or6c38'
ID 271218
Institutional Source Beutler Lab
Gene Symbol Or6c38
Ensembl Gene ENSMUSG00000050198
Gene Name olfactory receptor family 6 subfamily C member 38
Synonyms MOR114-4, Olfr768, GA_x6K02T2PULF-10779441-10778503
MMRRC Submission 040736-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R3751 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 128928903-128929841 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 128929175 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 223 (I223F)
Ref Sequence ENSEMBL: ENSMUSP00000089619 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063031]
AlphaFold Q8VGC4
Predicted Effect probably damaging
Transcript: ENSMUST00000063031
AA Change: I223F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000089619
Gene: ENSMUSG00000050198
AA Change: I223F

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.7e-50 PFAM
Pfam:7tm_1 39 288 5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216212
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216681
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 93% (43/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik G T 7: 12,289,973 (GRCm39) R183I probably benign Het
BC016579 A T 16: 45,453,361 (GRCm39) probably null Het
BC051665 A T 13: 60,931,145 (GRCm39) F258I probably damaging Het
Brd1 C T 15: 88,573,821 (GRCm39) V1093I possibly damaging Het
Ccdc125 A G 13: 100,814,459 (GRCm39) D13G possibly damaging Het
Ceacam18 T A 7: 43,291,372 (GRCm39) H271Q probably damaging Het
Cep104 A G 4: 154,066,213 (GRCm39) Y137C probably damaging Het
Clca3a1 A G 3: 144,724,424 (GRCm39) V212A probably benign Het
Clca3a2 A T 3: 144,777,216 (GRCm39) M885K probably benign Het
Col6a4 G T 9: 105,949,313 (GRCm39) T774N probably damaging Het
D430041D05Rik T C 2: 104,085,403 (GRCm39) T1049A possibly damaging Het
Dlk1 A G 12: 109,426,239 (GRCm39) I276V probably benign Het
E2f1 C G 2: 154,405,942 (GRCm39) G144R probably damaging Het
Efcab9 T C 11: 32,477,420 (GRCm39) H34R probably benign Het
Erc1 T A 6: 119,801,921 (GRCm39) H32L probably damaging Het
Ezh2 T C 6: 47,532,998 (GRCm39) I141M possibly damaging Het
Fbln1 T A 15: 85,111,279 (GRCm39) C144* probably null Het
Iqsec3 C T 6: 121,353,214 (GRCm39) A1135T probably benign Het
Irak4 T C 15: 94,459,476 (GRCm39) I364T probably damaging Het
Itpr1 T A 6: 108,326,641 (GRCm39) I121N probably damaging Het
Krtap17-1 A T 11: 99,884,481 (GRCm39) C95* probably null Het
Lrrd1 T A 5: 3,900,282 (GRCm39) S196T probably benign Het
Man2c1 A G 9: 57,048,058 (GRCm39) Y748C probably damaging Het
Map4 A G 9: 109,867,742 (GRCm39) probably benign Het
Mib2 A G 4: 155,739,741 (GRCm39) F810S probably damaging Het
Mtmr9 A G 14: 63,780,997 (GRCm39) L31P probably damaging Het
Myo5c A G 9: 75,183,284 (GRCm39) Q886R probably damaging Het
Nhsl3 A G 4: 129,118,115 (GRCm39) probably benign Het
Or2g1 T C 17: 38,107,123 (GRCm39) S263P possibly damaging Het
Or7h8 C T 9: 20,124,556 (GRCm39) L304F probably damaging Het
Paqr8 A G 1: 21,005,856 (GRCm39) T337A probably benign Het
Pdgfd A T 9: 6,337,447 (GRCm39) probably benign Het
Ppm1k T G 6: 57,501,845 (GRCm39) E106A probably benign Het
Rbp3 A T 14: 33,677,969 (GRCm39) E639V probably damaging Het
Rnf214 A C 9: 45,778,901 (GRCm39) I581S probably damaging Het
Scaf11 A G 15: 96,316,417 (GRCm39) V1049A probably damaging Het
Slc51a A G 16: 32,295,292 (GRCm39) L262P probably benign Het
Slc6a21 G A 7: 44,929,928 (GRCm39) V139I probably benign Het
Slc8a3 G T 12: 81,250,912 (GRCm39) L684M probably damaging Het
Spg7 G C 8: 123,814,112 (GRCm39) R457P probably damaging Het
Tnks1bp1 C T 2: 84,889,066 (GRCm39) probably benign Het
Vmn1r189 T C 13: 22,286,382 (GRCm39) T152A probably benign Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Zfp366 A G 13: 99,365,352 (GRCm39) Y171C probably damaging Het
Other mutations in Or6c38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Or6c38 APN 10 128,929,265 (GRCm39) missense probably benign 0.08
IGL01947:Or6c38 APN 10 128,929,747 (GRCm39) missense possibly damaging 0.52
IGL03026:Or6c38 APN 10 128,929,057 (GRCm39) missense possibly damaging 0.60
R1353:Or6c38 UTSW 10 128,929,733 (GRCm39) missense probably benign 0.14
R1426:Or6c38 UTSW 10 128,929,559 (GRCm39) missense probably damaging 1.00
R1766:Or6c38 UTSW 10 128,929,616 (GRCm39) missense probably benign 0.24
R2356:Or6c38 UTSW 10 128,929,761 (GRCm39) missense probably benign 0.40
R3522:Or6c38 UTSW 10 128,929,711 (GRCm39) missense possibly damaging 0.93
R3779:Or6c38 UTSW 10 128,929,165 (GRCm39) missense possibly damaging 0.94
R4582:Or6c38 UTSW 10 128,929,027 (GRCm39) missense possibly damaging 0.93
R4772:Or6c38 UTSW 10 128,929,537 (GRCm39) missense possibly damaging 0.92
R4792:Or6c38 UTSW 10 128,929,489 (GRCm39) missense probably damaging 1.00
R5749:Or6c38 UTSW 10 128,928,966 (GRCm39) missense probably damaging 0.98
R6571:Or6c38 UTSW 10 128,928,990 (GRCm39) missense probably damaging 0.98
R6619:Or6c38 UTSW 10 128,929,323 (GRCm39) missense possibly damaging 0.95
R7052:Or6c38 UTSW 10 128,929,744 (GRCm39) missense probably damaging 0.98
R7096:Or6c38 UTSW 10 128,929,715 (GRCm39) missense probably damaging 0.97
R7409:Or6c38 UTSW 10 128,929,081 (GRCm39) missense probably damaging 1.00
R7852:Or6c38 UTSW 10 128,929,385 (GRCm39) missense probably benign 0.45
R8332:Or6c38 UTSW 10 128,929,174 (GRCm39) missense possibly damaging 0.95
R9183:Or6c38 UTSW 10 128,929,201 (GRCm39) missense probably benign 0.06
R9245:Or6c38 UTSW 10 128,929,472 (GRCm39) missense probably damaging 1.00
X0024:Or6c38 UTSW 10 128,929,216 (GRCm39) missense probably damaging 1.00
X0024:Or6c38 UTSW 10 128,928,984 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GAAGTCGTGAGCACAGACAC -3'
(R):5'- ACAGGGTCTGCATCCAGTTC -3'

Sequencing Primer
(F):5'- GTGAGCACAGACACAACCTTATTTAC -3'
(R):5'- TGTCATCCCACCTTATAGCATAAG -3'
Posted On 2015-03-18