Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00949:Ptgfrn'

27125

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ptgfrn

Ensembl Gene

ENSMUSG00000027864

Gene Name

prostaglandin F2 receptor negative regulator

Synonyms

CD9P-1, 4833445A08Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00949

Quality Score

Status

Chromosome

Chromosomal Location

101040232-101110278 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 101072845 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 393 (M393K)

Ref Sequence

ENSEMBL: ENSMUSP00000099755 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102694]

Predicted Effect

probably benign
Transcript: ENSMUST00000102694
AA Change: M393K

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000099755
Gene: ENSMUSG00000027864
AA Change: M393K

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGv	38	121	3.01e-7	SMART
IG	154	264	1.54e-4	SMART
IG	284	390	1.11e-5	SMART
IG	414	532	1.72e-2	SMART
IG	556	676	9.71e-2	SMART
IG	696	822	5.21e-2	SMART
transmembrane domain	831	853	N/A	INTRINSIC
low complexity region	862	872	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198037

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200065

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice for a null gene trap mutation exhibit a decreased depressive-like response during tail suspension testing when compared with their wild-type littermates, [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl4	A	G	X: 142,343,329	C303R	probably damaging	Het
Als2	C	T	1: 59,215,572	G209S	probably damaging	Het
Ankrd11	T	C	8: 122,908,728	T56A	possibly damaging	Het
Arnt	T	A	3: 95,487,268	I381N	probably damaging	Het
Atp13a1	T	C	8: 69,800,003		probably benign	Het
Cd180	A	T	13: 102,693,760	T21S	possibly damaging	Het
Cdc27	T	C	11: 104,529,403	Y138C	probably damaging	Het
Dhx16	A	G	17: 35,887,934	T753A	probably benign	Het
Dnah1	A	G	14: 31,307,090	M561T	probably benign	Het
Dsc3	C	A	18: 19,985,631	G259C	probably null	Het
Enox2	A	T	X: 49,040,607	D346E	probably benign	Het
Exoc3l	T	C	8: 105,290,498	E619G	probably benign	Het
Exosc9	T	C	3: 36,563,266		probably benign	Het
Gmpr2	C	T	14: 55,676,750		probably benign	Het
Golga1	T	C	2: 39,041,255	E289G	probably damaging	Het
Hist1h3a	G	A	13: 23,762,031	T108I	probably damaging	Het
Jmy	A	G	13: 93,454,002	V531A	probably damaging	Het
Lamp2	T	C	X: 38,435,473	N156S	probably benign	Het
Lrrn1	C	A	6: 107,569,300	N686K	probably benign	Het
Lyst	T	C	13: 13,635,485	V580A	possibly damaging	Het
Ms4a8a	C	A	19: 11,079,444	L91F	probably benign	Het
Naip2	A	G	13: 100,161,591	F646L	probably damaging	Het
Npat	T	C	9: 53,563,362	V818A	probably benign	Het
Olfr1362	A	T	13: 21,611,351	I206N	probably damaging	Het
Padi3	C	A	4: 140,788,943	R542L	possibly damaging	Het
Pid1	A	G	1: 84,038,506	V46A	probably damaging	Het
Pld5	A	T	1: 175,975,473	C409S	probably damaging	Het
Plet1	A	G	9: 50,499,223	T105A	possibly damaging	Het
Polrmt	T	C	10: 79,737,597		probably null	Het
Pp2d1	T	C	17: 53,515,639	N133S	probably benign	Het
Prpf40b	G	T	15: 99,306,538	V228L	probably benign	Het
Slc9a1	C	T	4: 133,416,451	T416I	probably benign	Het
Slc9c1	T	C	16: 45,593,358	S950P	probably benign	Het
Slitrk1	A	T	14: 108,911,809	V490D	probably damaging	Het
Th	T	C	7: 142,897,026	Y131C	probably benign	Het
Tlr6	A	G	5: 64,953,512	L684P	probably damaging	Het
Tpm3	A	G	3: 90,089,858	E234G	probably damaging	Het
Tti1	A	G	2: 157,982,399	Y1045H	probably benign	Het
Txnl4b	T	A	8: 109,569,075	V37D	probably benign	Het
Ufl1	A	T	4: 25,275,822	F194I	probably damaging	Het
Usp13	G	A	3: 32,886,577	E412K	possibly damaging	Het
Usp46	A	T	5: 74,003,242	L251Q	possibly damaging	Het

Other mutations in Ptgfrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01710:Ptgfrn	APN	3	101073088	missense	probably damaging	0.98
IGL02557:Ptgfrn	APN	3	101060636	critical splice donor site	probably null
IGL02740:Ptgfrn	APN	3	101072937	missense	possibly damaging	0.84
IGL02817:Ptgfrn	APN	3	101060752	missense	probably benign
IGL02948:Ptgfrn	APN	3	101072819	missense	probably benign	0.21
R1540:Ptgfrn	UTSW	3	101060654	missense	probably benign	0.41
R1563:Ptgfrn	UTSW	3	101060651	missense	possibly damaging	0.67
R1730:Ptgfrn	UTSW	3	101056442	missense	possibly damaging	0.71
R1766:Ptgfrn	UTSW	3	101050122	missense	probably benign	0.00
R1783:Ptgfrn	UTSW	3	101056442	missense	possibly damaging	0.71
R1918:Ptgfrn	UTSW	3	101056307	missense	probably benign
R2113:Ptgfrn	UTSW	3	101077309	missense	probably benign	0.00
R2290:Ptgfrn	UTSW	3	101077361	missense	possibly damaging	0.77
R3522:Ptgfrn	UTSW	3	101043402	missense	probably damaging	1.00
R5223:Ptgfrn	UTSW	3	101045593	missense	probably benign	0.13
R5600:Ptgfrn	UTSW	3	101056250	missense	probably damaging	0.99
R5642:Ptgfrn	UTSW	3	101043362	missense	probably damaging	1.00
R5927:Ptgfrn	UTSW	3	101060652	missense	possibly damaging	0.92
R5984:Ptgfrn	UTSW	3	101050143	missense	probably damaging	0.99
R6124:Ptgfrn	UTSW	3	101073089	missense	probably damaging	0.98
R6331:Ptgfrn	UTSW	3	101045620	missense	possibly damaging	0.64
R6363:Ptgfrn	UTSW	3	101045578	missense	possibly damaging	0.93
R6473:Ptgfrn	UTSW	3	101045639	missense	probably damaging	1.00
R6856:Ptgfrn	UTSW	3	101045446	missense	probably damaging	1.00
R7151:Ptgfrn	UTSW	3	101080195	nonsense	probably null
R7313:Ptgfrn	UTSW	3	101073047	missense	possibly damaging	0.84
R7361:Ptgfrn	UTSW	3	101077444	missense	probably benign	0.03
R7806:Ptgfrn	UTSW	3	101077132	missense	possibly damaging	0.50
R7823:Ptgfrn	UTSW	3	101043409	missense	probably damaging	1.00
R7841:Ptgfrn	UTSW	3	101060810	missense	probably damaging	0.98
R7924:Ptgfrn	UTSW	3	101060810	missense	probably damaging	0.98
Z1088:Ptgfrn	UTSW	3	101056437	missense	probably damaging	1.00

Posted On

2013-04-17