Incidental Mutation 'IGL00949:Ptgfrn'
| ID |
27125 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ptgfrn
|
| Ensembl Gene |
ENSMUSG00000027864 |
| Gene Name |
prostaglandin F2 receptor negative regulator |
| Synonyms |
4833445A08Rik, CD9P-1 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00949
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
100947548-101017594 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 100980161 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 393
(M393K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099755
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102694]
|
| AlphaFold |
Q9WV91 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102694
AA Change: M393K
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000099755
Gene: ENSMUSG00000027864
AA Change: M393K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
IGv
|
38 |
121 |
3.01e-7 |
SMART |
|
IG
|
154 |
264 |
1.54e-4 |
SMART |
|
IG
|
284 |
390 |
1.11e-5 |
SMART |
|
IG
|
414 |
532 |
1.72e-2 |
SMART |
|
IG
|
556 |
676 |
9.71e-2 |
SMART |
|
IG
|
696 |
822 |
5.21e-2 |
SMART |
|
transmembrane domain
|
831 |
853 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
872 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198037
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200065
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous mice for a null gene trap mutation exhibit a decreased depressive-like response during tail suspension testing when compared with their wild-type littermates, [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsl4 |
A |
G |
X: 141,126,325 (GRCm39) |
C303R |
probably damaging |
Het |
| Als2 |
C |
T |
1: 59,254,731 (GRCm39) |
G209S |
probably damaging |
Het |
| Ankrd11 |
T |
C |
8: 123,635,467 (GRCm39) |
T56A |
possibly damaging |
Het |
| Arnt |
T |
A |
3: 95,394,579 (GRCm39) |
I381N |
probably damaging |
Het |
| Atp13a1 |
T |
C |
8: 70,252,653 (GRCm39) |
|
probably benign |
Het |
| Cd180 |
A |
T |
13: 102,830,268 (GRCm39) |
T21S |
possibly damaging |
Het |
| Cdc27 |
T |
C |
11: 104,420,229 (GRCm39) |
Y138C |
probably damaging |
Het |
| Dhx16 |
A |
G |
17: 36,198,826 (GRCm39) |
T753A |
probably benign |
Het |
| Dnah1 |
A |
G |
14: 31,029,047 (GRCm39) |
M561T |
probably benign |
Het |
| Dsc3 |
C |
A |
18: 20,118,688 (GRCm39) |
G259C |
probably null |
Het |
| Enox2 |
A |
T |
X: 48,129,484 (GRCm39) |
D346E |
probably benign |
Het |
| Exoc3l |
T |
C |
8: 106,017,130 (GRCm39) |
E619G |
probably benign |
Het |
| Exosc9 |
T |
C |
3: 36,617,415 (GRCm39) |
|
probably benign |
Het |
| Gmpr2 |
C |
T |
14: 55,914,207 (GRCm39) |
|
probably benign |
Het |
| Golga1 |
T |
C |
2: 38,931,267 (GRCm39) |
E289G |
probably damaging |
Het |
| H3c1 |
G |
A |
13: 23,946,014 (GRCm39) |
T108I |
probably damaging |
Het |
| Jmy |
A |
G |
13: 93,590,510 (GRCm39) |
V531A |
probably damaging |
Het |
| Lamp2 |
T |
C |
X: 37,524,350 (GRCm39) |
N156S |
probably benign |
Het |
| Lrrn1 |
C |
A |
6: 107,546,261 (GRCm39) |
N686K |
probably benign |
Het |
| Lyst |
T |
C |
13: 13,810,070 (GRCm39) |
V580A |
possibly damaging |
Het |
| Ms4a8a |
C |
A |
19: 11,056,808 (GRCm39) |
L91F |
probably benign |
Het |
| Naip2 |
A |
G |
13: 100,298,099 (GRCm39) |
F646L |
probably damaging |
Het |
| Npat |
T |
C |
9: 53,474,662 (GRCm39) |
V818A |
probably benign |
Het |
| Or2w4 |
A |
T |
13: 21,795,521 (GRCm39) |
I206N |
probably damaging |
Het |
| Padi3 |
C |
A |
4: 140,516,254 (GRCm39) |
R542L |
possibly damaging |
Het |
| Pid1 |
A |
G |
1: 84,016,227 (GRCm39) |
V46A |
probably damaging |
Het |
| Pld5 |
A |
T |
1: 175,803,039 (GRCm39) |
C409S |
probably damaging |
Het |
| Plet1 |
A |
G |
9: 50,410,523 (GRCm39) |
T105A |
possibly damaging |
Het |
| Polrmt |
T |
C |
10: 79,573,431 (GRCm39) |
|
probably null |
Het |
| Pp2d1 |
T |
C |
17: 53,822,667 (GRCm39) |
N133S |
probably benign |
Het |
| Prpf40b |
G |
T |
15: 99,204,419 (GRCm39) |
V228L |
probably benign |
Het |
| Slc9a1 |
C |
T |
4: 133,143,762 (GRCm39) |
T416I |
probably benign |
Het |
| Slc9c1 |
T |
C |
16: 45,413,721 (GRCm39) |
S950P |
probably benign |
Het |
| Slitrk1 |
A |
T |
14: 109,149,241 (GRCm39) |
V490D |
probably damaging |
Het |
| Th |
T |
C |
7: 142,450,763 (GRCm39) |
Y131C |
probably benign |
Het |
| Tlr6 |
A |
G |
5: 65,110,855 (GRCm39) |
L684P |
probably damaging |
Het |
| Tpm3 |
A |
G |
3: 89,997,165 (GRCm39) |
E234G |
probably damaging |
Het |
| Tti1 |
A |
G |
2: 157,824,319 (GRCm39) |
Y1045H |
probably benign |
Het |
| Txnl4b |
T |
A |
8: 110,295,707 (GRCm39) |
V37D |
probably benign |
Het |
| Ufl1 |
A |
T |
4: 25,275,822 (GRCm39) |
F194I |
probably damaging |
Het |
| Usp13 |
G |
A |
3: 32,940,726 (GRCm39) |
E412K |
possibly damaging |
Het |
| Usp46 |
A |
T |
5: 74,163,903 (GRCm39) |
L251Q |
possibly damaging |
Het |
|
| Other mutations in Ptgfrn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01710:Ptgfrn
|
APN |
3 |
100,980,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02557:Ptgfrn
|
APN |
3 |
100,967,952 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02740:Ptgfrn
|
APN |
3 |
100,980,253 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02817:Ptgfrn
|
APN |
3 |
100,968,068 (GRCm39) |
missense |
probably benign |
|
|
IGL02948:Ptgfrn
|
APN |
3 |
100,980,135 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1540:Ptgfrn
|
UTSW |
3 |
100,967,970 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1563:Ptgfrn
|
UTSW |
3 |
100,967,967 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1730:Ptgfrn
|
UTSW |
3 |
100,963,758 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1766:Ptgfrn
|
UTSW |
3 |
100,957,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Ptgfrn
|
UTSW |
3 |
100,963,758 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1918:Ptgfrn
|
UTSW |
3 |
100,963,623 (GRCm39) |
missense |
probably benign |
|
|
R2113:Ptgfrn
|
UTSW |
3 |
100,984,625 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2290:Ptgfrn
|
UTSW |
3 |
100,984,677 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3522:Ptgfrn
|
UTSW |
3 |
100,950,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5223:Ptgfrn
|
UTSW |
3 |
100,952,909 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5600:Ptgfrn
|
UTSW |
3 |
100,963,566 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5642:Ptgfrn
|
UTSW |
3 |
100,950,678 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5927:Ptgfrn
|
UTSW |
3 |
100,967,968 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5984:Ptgfrn
|
UTSW |
3 |
100,957,459 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6124:Ptgfrn
|
UTSW |
3 |
100,980,405 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6331:Ptgfrn
|
UTSW |
3 |
100,952,936 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6363:Ptgfrn
|
UTSW |
3 |
100,952,894 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6473:Ptgfrn
|
UTSW |
3 |
100,952,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6856:Ptgfrn
|
UTSW |
3 |
100,952,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Ptgfrn
|
UTSW |
3 |
100,987,511 (GRCm39) |
nonsense |
probably null |
|
|
R7313:Ptgfrn
|
UTSW |
3 |
100,980,363 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7361:Ptgfrn
|
UTSW |
3 |
100,984,760 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7806:Ptgfrn
|
UTSW |
3 |
100,984,448 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7823:Ptgfrn
|
UTSW |
3 |
100,950,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7841:Ptgfrn
|
UTSW |
3 |
100,968,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8093:Ptgfrn
|
UTSW |
3 |
100,980,257 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8093:Ptgfrn
|
UTSW |
3 |
100,963,753 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8490:Ptgfrn
|
UTSW |
3 |
100,963,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8856:Ptgfrn
|
UTSW |
3 |
100,963,927 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1088:Ptgfrn
|
UTSW |
3 |
100,963,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-04-17 |
Incidental Mutation