Incidental Mutation 'R3757:Lypd1'
ID |
271466 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Lypd1
|
Ensembl Gene |
ENSMUSG00000026344 |
Gene Name |
Ly6/Plaur domain containing 1 |
Synonyms |
C530008O16Rik, 2700050C12Rik, Lynx2 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.060)
|
Stock # |
R3757 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
1 |
Chromosomal Location |
125795359-125840838 bp(-) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to G
at 125838121 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000125158
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027582]
[ENSMUST00000057846]
[ENSMUST00000094609]
[ENSMUST00000094610]
[ENSMUST00000112583]
[ENSMUST00000159417]
[ENSMUST00000159529]
[ENSMUST00000162899]
[ENSMUST00000161361]
[ENSMUST00000161954]
[ENSMUST00000162877]
|
AlphaFold |
Q8BLC3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000027582
|
SMART Domains |
Protein: ENSMUSP00000027582 Gene: ENSMUSG00000026344
Domain | Start | End | E-Value | Type |
LU
|
24 |
122 |
5.18e-2 |
SMART |
low complexity region
|
126 |
142 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000057846
|
SMART Domains |
Protein: ENSMUSP00000062229 Gene: ENSMUSG00000049690
Domain | Start | End | E-Value | Type |
low complexity region
|
2 |
25 |
N/A |
INTRINSIC |
coiled coil region
|
108 |
186 |
N/A |
INTRINSIC |
low complexity region
|
321 |
332 |
N/A |
INTRINSIC |
low complexity region
|
755 |
771 |
N/A |
INTRINSIC |
low complexity region
|
950 |
971 |
N/A |
INTRINSIC |
low complexity region
|
1070 |
1085 |
N/A |
INTRINSIC |
low complexity region
|
1181 |
1200 |
N/A |
INTRINSIC |
Pfam:NCKAP5
|
1298 |
1602 |
1.8e-120 |
PFAM |
low complexity region
|
1728 |
1742 |
N/A |
INTRINSIC |
low complexity region
|
1757 |
1771 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000094609
|
SMART Domains |
Protein: ENSMUSP00000092192 Gene: ENSMUSG00000049690
Domain | Start | End | E-Value | Type |
low complexity region
|
70 |
93 |
N/A |
INTRINSIC |
Pfam:NCKAP5
|
113 |
364 |
3.6e-36 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000094610
|
SMART Domains |
Protein: ENSMUSP00000092193 Gene: ENSMUSG00000049690
Domain | Start | End | E-Value | Type |
Pfam:NCKAP5
|
1 |
101 |
8.8e-42 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000112583
|
SMART Domains |
Protein: ENSMUSP00000108202 Gene: ENSMUSG00000049690
Domain | Start | End | E-Value | Type |
low complexity region
|
70 |
93 |
N/A |
INTRINSIC |
coiled coil region
|
176 |
254 |
N/A |
INTRINSIC |
low complexity region
|
301 |
324 |
N/A |
INTRINSIC |
low complexity region
|
453 |
464 |
N/A |
INTRINSIC |
low complexity region
|
887 |
903 |
N/A |
INTRINSIC |
low complexity region
|
1082 |
1103 |
N/A |
INTRINSIC |
low complexity region
|
1202 |
1217 |
N/A |
INTRINSIC |
low complexity region
|
1313 |
1332 |
N/A |
INTRINSIC |
Pfam:NCKAP5
|
1431 |
1733 |
5.3e-119 |
PFAM |
low complexity region
|
1860 |
1874 |
N/A |
INTRINSIC |
low complexity region
|
1889 |
1903 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000159417
|
SMART Domains |
Protein: ENSMUSP00000125149 Gene: ENSMUSG00000026344
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
LU
|
23 |
121 |
2.5e-4 |
SMART |
low complexity region
|
125 |
140 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000159529
|
SMART Domains |
Protein: ENSMUSP00000123824 Gene: ENSMUSG00000026344
Domain | Start | End | E-Value | Type |
Blast:LU
|
1 |
69 |
4e-32 |
BLAST |
low complexity region
|
73 |
89 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000162899
|
SMART Domains |
Protein: ENSMUSP00000125158 Gene: ENSMUSG00000026344
Domain | Start | End | E-Value | Type |
Blast:LU
|
1 |
69 |
4e-32 |
BLAST |
low complexity region
|
73 |
89 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000161361
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160736
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000161954
|
SMART Domains |
Protein: ENSMUSP00000125624 Gene: ENSMUSG00000049690
Domain | Start | End | E-Value | Type |
low complexity region
|
2 |
25 |
N/A |
INTRINSIC |
coiled coil region
|
108 |
186 |
N/A |
INTRINSIC |
low complexity region
|
233 |
256 |
N/A |
INTRINSIC |
low complexity region
|
385 |
396 |
N/A |
INTRINSIC |
low complexity region
|
819 |
835 |
N/A |
INTRINSIC |
low complexity region
|
1014 |
1035 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1149 |
N/A |
INTRINSIC |
low complexity region
|
1245 |
1264 |
N/A |
INTRINSIC |
Pfam:NCKAP5
|
1362 |
1666 |
2.1e-120 |
PFAM |
low complexity region
|
1792 |
1806 |
N/A |
INTRINSIC |
low complexity region
|
1821 |
1835 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000162877
|
SMART Domains |
Protein: ENSMUSP00000124748 Gene: ENSMUSG00000049690
Domain | Start | End | E-Value | Type |
Pfam:NCKAP5
|
9 |
296 |
6e-36 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.3%
|
Validation Efficiency |
92% (35/38) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit increased fear and anxiety behaviors with increased spontaneous excitatory postsynaptic current following nicotine treatment. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adamtsl3 |
T |
A |
7: 81,986,415 (GRCm39) |
I9K |
probably benign |
Het |
Arhgap31 |
T |
C |
16: 38,457,362 (GRCm39) |
E82G |
probably damaging |
Het |
Asap2 |
T |
A |
12: 21,317,767 (GRCm39) |
S993T |
probably damaging |
Het |
Bmpr1a |
A |
T |
14: 34,156,624 (GRCm39) |
L134* |
probably null |
Het |
Cacna1e |
A |
G |
1: 154,509,442 (GRCm39) |
V271A |
probably damaging |
Het |
Cacna2d4 |
A |
G |
6: 119,218,124 (GRCm39) |
E153G |
probably damaging |
Het |
Cage1 |
A |
C |
13: 38,209,705 (GRCm39) |
F91V |
possibly damaging |
Het |
Cdh24 |
T |
C |
14: 54,869,637 (GRCm39) |
D760G |
possibly damaging |
Het |
Col9a1 |
T |
C |
1: 24,271,312 (GRCm39) |
|
probably null |
Het |
Cts6 |
A |
T |
13: 61,349,972 (GRCm39) |
Y36* |
probably null |
Het |
Dennd3 |
C |
G |
15: 73,394,083 (GRCm39) |
A36G |
probably benign |
Het |
Dmxl1 |
G |
A |
18: 50,068,384 (GRCm39) |
G2719D |
probably damaging |
Het |
Dnajc28 |
G |
A |
16: 91,413,755 (GRCm39) |
T187M |
probably damaging |
Het |
Ep300 |
T |
A |
15: 81,532,790 (GRCm39) |
V1676E |
unknown |
Het |
Ercc4 |
C |
T |
16: 12,962,360 (GRCm39) |
T668M |
probably benign |
Het |
G530012D18Rik |
CAGAGAGA |
CAGAGAGAGA |
1: 85,504,945 (GRCm39) |
|
probably null |
Het |
Gm10985 |
GCTCTCTCTCTCTCTCTCTCTCTCTCTCT |
GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT |
3: 53,752,645 (GRCm39) |
|
probably null |
Het |
H1f4 |
T |
A |
13: 23,806,240 (GRCm39) |
K81* |
probably null |
Het |
Havcr1 |
G |
T |
11: 46,643,407 (GRCm39) |
R109L |
probably damaging |
Het |
Krtap4-9 |
A |
G |
11: 99,676,444 (GRCm39) |
|
probably benign |
Het |
Layn |
T |
C |
9: 50,970,856 (GRCm39) |
E229G |
probably benign |
Het |
Lpcat3 |
T |
A |
6: 124,676,955 (GRCm39) |
|
probably null |
Het |
Lrrn1 |
T |
A |
6: 107,546,169 (GRCm39) |
F656I |
possibly damaging |
Het |
Or4k41 |
T |
A |
2: 111,279,602 (GRCm39) |
V39E |
possibly damaging |
Het |
Or5v1b |
T |
A |
17: 37,841,246 (GRCm39) |
I126N |
probably damaging |
Het |
Or6c207 |
T |
C |
10: 129,104,934 (GRCm39) |
D86G |
probably damaging |
Het |
Ptprt |
A |
T |
2: 161,653,950 (GRCm39) |
L560Q |
probably damaging |
Het |
Rbm11 |
T |
C |
16: 75,393,469 (GRCm39) |
V55A |
probably damaging |
Het |
Scn11a |
C |
T |
9: 119,632,569 (GRCm39) |
V434I |
probably benign |
Het |
Serpinc1 |
A |
G |
1: 160,829,935 (GRCm39) |
T434A |
probably benign |
Het |
Setd2 |
T |
C |
9: 110,402,753 (GRCm39) |
I1798T |
probably damaging |
Het |
Sfswap |
A |
G |
5: 129,590,298 (GRCm39) |
Y265C |
probably damaging |
Het |
Slc9a8 |
C |
A |
2: 167,266,050 (GRCm39) |
T9K |
probably benign |
Het |
Synpo |
T |
C |
18: 60,736,062 (GRCm39) |
D389G |
probably damaging |
Het |
Vmn1r181 |
C |
T |
7: 23,683,909 (GRCm39) |
L125F |
possibly damaging |
Het |
Wdfy4 |
A |
C |
14: 32,745,331 (GRCm39) |
H2296Q |
probably benign |
Het |
|
Other mutations in Lypd1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
H8562:Lypd1
|
UTSW |
1 |
125,838,274 (GRCm39) |
splice site |
probably benign |
|
R0015:Lypd1
|
UTSW |
1 |
125,838,175 (GRCm39) |
missense |
possibly damaging |
0.59 |
R0537:Lypd1
|
UTSW |
1 |
125,840,604 (GRCm39) |
unclassified |
probably benign |
|
R1838:Lypd1
|
UTSW |
1 |
125,801,108 (GRCm39) |
unclassified |
probably benign |
|
R2045:Lypd1
|
UTSW |
1 |
125,838,272 (GRCm39) |
splice site |
probably benign |
|
R6906:Lypd1
|
UTSW |
1 |
125,838,196 (GRCm39) |
missense |
probably damaging |
0.99 |
R7453:Lypd1
|
UTSW |
1 |
125,801,303 (GRCm39) |
missense |
probably benign |
|
R8916:Lypd1
|
UTSW |
1 |
125,801,120 (GRCm39) |
missense |
unknown |
|
|
Predicted Primers |
PCR Primer
(F):5'- GCCCTGGCAATTAACCCTAATG -3'
(R):5'- AGTGTTTCTGAACCCCACCG -3'
Sequencing Primer
(F):5'- ACATCTGTGCTAACCAGTGAGTG -3'
(R):5'- ACCGCATCTGTCCCACAGG -3'
|
Posted On |
2015-03-18 |