Incidental Mutation 'R3757:Lrrn1'
ID 271476
Institutional Source Beutler Lab
Gene Symbol Lrrn1
Ensembl Gene ENSMUSG00000034648
Gene Name leucine rich repeat protein 1, neuronal
Synonyms 2810047E21Rik, NLRR-1
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.339) question?
Stock # R3757 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 107506729-107547175 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 107546169 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 656 (F656I)
Ref Sequence ENSEMBL: ENSMUSP00000037096 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049285]
AlphaFold Q61809
Predicted Effect possibly damaging
Transcript: ENSMUST00000049285
AA Change: F656I

PolyPhen 2 Score 0.812 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000037096
Gene: ENSMUSG00000034648
AA Change: F656I

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 31 76 2.89e-1 SMART
LRR 94 117 1.06e1 SMART
LRR 118 141 1.89e-1 SMART
LRR_TYP 142 165 4.3e-5 SMART
LRR 166 189 1.76e-1 SMART
LRR 214 237 4.09e1 SMART
LRR 238 261 1.53e1 SMART
LRR 262 285 2.63e0 SMART
LRR 311 335 1.45e2 SMART
LRR 336 359 4.21e1 SMART
LRRCT 371 423 2.14e-10 SMART
IGc2 438 506 6.34e-15 SMART
FN3 523 605 8.71e-2 SMART
transmembrane domain 631 653 N/A INTRINSIC
low complexity region 690 701 N/A INTRINSIC
Meta Mutation Damage Score 0.0587 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
MGI Phenotype PHENOTYPE: Homozygous null mutant mice exhibited decreased exploratory activity and the female mutants exhibited an increased anxiety-like response during open field testing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Lrrn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Lrrn1 APN 6 107,545,269 (GRCm39) missense probably benign 0.06
IGL00949:Lrrn1 APN 6 107,546,261 (GRCm39) missense probably benign 0.15
IGL01594:Lrrn1 APN 6 107,544,454 (GRCm39) missense probably damaging 0.99
IGL02814:Lrrn1 APN 6 107,544,313 (GRCm39) missense probably damaging 1.00
IGL02824:Lrrn1 APN 6 107,545,495 (GRCm39) missense possibly damaging 0.57
IGL02931:Lrrn1 APN 6 107,544,709 (GRCm39) missense probably damaging 1.00
R0399:Lrrn1 UTSW 6 107,546,081 (GRCm39) missense probably benign
R1109:Lrrn1 UTSW 6 107,544,225 (GRCm39) missense probably benign
R1620:Lrrn1 UTSW 6 107,545,327 (GRCm39) missense probably damaging 1.00
R1826:Lrrn1 UTSW 6 107,544,529 (GRCm39) missense probably benign 0.05
R1893:Lrrn1 UTSW 6 107,545,083 (GRCm39) missense possibly damaging 0.82
R2327:Lrrn1 UTSW 6 107,545,794 (GRCm39) missense probably benign 0.05
R3684:Lrrn1 UTSW 6 107,544,910 (GRCm39) missense probably benign 0.13
R4538:Lrrn1 UTSW 6 107,545,598 (GRCm39) missense probably benign 0.21
R4922:Lrrn1 UTSW 6 107,545,311 (GRCm39) missense probably damaging 1.00
R4946:Lrrn1 UTSW 6 107,545,851 (GRCm39) missense probably benign 0.16
R4970:Lrrn1 UTSW 6 107,546,305 (GRCm39) missense probably benign 0.06
R4977:Lrrn1 UTSW 6 107,545,668 (GRCm39) missense probably benign
R5121:Lrrn1 UTSW 6 107,546,168 (GRCm39) missense possibly damaging 0.89
R5186:Lrrn1 UTSW 6 107,546,185 (GRCm39) missense probably damaging 1.00
R5625:Lrrn1 UTSW 6 107,544,315 (GRCm39) missense probably damaging 0.99
R5736:Lrrn1 UTSW 6 107,544,345 (GRCm39) missense probably damaging 1.00
R5873:Lrrn1 UTSW 6 107,545,936 (GRCm39) missense probably damaging 0.98
R5949:Lrrn1 UTSW 6 107,544,465 (GRCm39) missense probably benign 0.00
R6046:Lrrn1 UTSW 6 107,545,488 (GRCm39) missense probably benign 0.00
R6370:Lrrn1 UTSW 6 107,546,185 (GRCm39) missense probably damaging 1.00
R7138:Lrrn1 UTSW 6 107,545,336 (GRCm39) missense probably damaging 1.00
R7169:Lrrn1 UTSW 6 107,544,565 (GRCm39) missense probably damaging 1.00
R7413:Lrrn1 UTSW 6 107,546,083 (GRCm39) missense probably benign 0.00
R7449:Lrrn1 UTSW 6 107,545,482 (GRCm39) missense possibly damaging 0.91
R7969:Lrrn1 UTSW 6 107,544,811 (GRCm39) missense probably damaging 1.00
R8077:Lrrn1 UTSW 6 107,545,783 (GRCm39) missense probably damaging 0.99
R8288:Lrrn1 UTSW 6 107,543,955 (GRCm39) start gained probably benign
R8420:Lrrn1 UTSW 6 107,546,294 (GRCm39) missense probably benign 0.00
R8725:Lrrn1 UTSW 6 107,544,303 (GRCm39) nonsense probably null
R9007:Lrrn1 UTSW 6 107,544,820 (GRCm39) missense probably damaging 0.99
R9133:Lrrn1 UTSW 6 107,544,568 (GRCm39) missense probably damaging 1.00
R9367:Lrrn1 UTSW 6 107,545,093 (GRCm39) missense probably damaging 0.98
R9373:Lrrn1 UTSW 6 107,545,465 (GRCm39) missense possibly damaging 0.82
R9475:Lrrn1 UTSW 6 107,545,261 (GRCm39) missense probably damaging 1.00
R9513:Lrrn1 UTSW 6 107,545,505 (GRCm39) missense probably benign 0.04
R9516:Lrrn1 UTSW 6 107,545,505 (GRCm39) missense probably benign 0.04
R9549:Lrrn1 UTSW 6 107,545,978 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGGTGTCCAACATCCATCAG -3'
(R):5'- TGTGCTCCTTACTACCAGAAGC -3'

Sequencing Primer
(F):5'- GTGTCCAACATCCATCAGCAGAC -3'
(R):5'- CCACATGTAATAGCTTCTGGATGTG -3'
Posted On 2015-03-18