Incidental Mutation 'R3757:Vmn1r181'
ID 271480
Institutional Source Beutler Lab
Gene Symbol Vmn1r181
Ensembl Gene ENSMUSG00000097425
Gene Name vomeronasal 1 receptor 181
Synonyms V1rd20
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R3757 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 23683386-23684473 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 23683909 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 125 (L125F)
Ref Sequence ENSEMBL: ENSMUSP00000154403 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000181796] [ENSMUST00000226843] [ENSMUST00000226978] [ENSMUST00000227637] [ENSMUST00000228399] [ENSMUST00000228842]
AlphaFold Q0P547
Predicted Effect possibly damaging
Transcript: ENSMUST00000077386
AA Change: L125F

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000076604
Gene: ENSMUSG00000057946
AA Change: L125F

DomainStartEndE-ValueType
Pfam:TAS2R 8 295 3.6e-12 PFAM
Pfam:7tm_1 30 282 4.6e-7 PFAM
Pfam:V1R 41 295 4.2e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000181796
AA Change: L125F

PolyPhen 2 Score 0.373 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000137685
Gene: ENSMUSG00000097425
AA Change: L125F

DomainStartEndE-ValueType
Pfam:TAS2R 8 296 3.9e-9 PFAM
Pfam:V1R 41 295 2.7e-13 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226843
AA Change: L125F

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000226978
AA Change: L125F

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227637
AA Change: L125F

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228399
AA Change: L125F

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228842
AA Change: L125F

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228607
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228531
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Vmn1r181
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01443:Vmn1r181 APN 7 23,684,006 (GRCm39) missense possibly damaging 0.91
IGL02055:Vmn1r181 APN 7 23,683,978 (GRCm39) missense probably damaging 1.00
IGL02444:Vmn1r181 APN 7 23,683,948 (GRCm39) missense probably damaging 1.00
IGL03012:Vmn1r181 APN 7 23,684,027 (GRCm39) missense probably damaging 0.98
IGL03026:Vmn1r181 APN 7 23,684,000 (GRCm39) missense possibly damaging 0.94
R0255:Vmn1r181 UTSW 7 23,683,759 (GRCm39) missense probably benign 0.02
R1481:Vmn1r181 UTSW 7 23,684,137 (GRCm39) missense probably damaging 1.00
R2847:Vmn1r181 UTSW 7 23,683,943 (GRCm39) missense possibly damaging 0.88
R2848:Vmn1r181 UTSW 7 23,683,943 (GRCm39) missense possibly damaging 0.88
R2849:Vmn1r181 UTSW 7 23,683,943 (GRCm39) missense possibly damaging 0.88
R3441:Vmn1r181 UTSW 7 23,684,308 (GRCm39) missense probably benign 0.05
R3945:Vmn1r181 UTSW 7 23,683,577 (GRCm39) missense probably damaging 0.98
R3983:Vmn1r181 UTSW 7 23,684,234 (GRCm39) missense probably benign 0.23
R4780:Vmn1r181 UTSW 7 23,684,008 (GRCm39) missense possibly damaging 0.64
R4999:Vmn1r181 UTSW 7 23,683,790 (GRCm39) missense probably damaging 0.99
R5463:Vmn1r181 UTSW 7 23,683,787 (GRCm39) missense probably benign 0.02
R5672:Vmn1r181 UTSW 7 23,683,741 (GRCm39) missense probably damaging 1.00
R6229:Vmn1r181 UTSW 7 23,683,580 (GRCm39) missense probably damaging 1.00
R6315:Vmn1r181 UTSW 7 23,684,183 (GRCm39) missense probably benign 0.23
R6316:Vmn1r181 UTSW 7 23,684,183 (GRCm39) missense probably benign 0.23
R6317:Vmn1r181 UTSW 7 23,684,183 (GRCm39) missense probably benign 0.23
R6324:Vmn1r181 UTSW 7 23,684,183 (GRCm39) missense probably benign 0.23
R6326:Vmn1r181 UTSW 7 23,684,183 (GRCm39) missense probably benign 0.23
R6988:Vmn1r181 UTSW 7 23,684,272 (GRCm39) missense probably damaging 1.00
R7446:Vmn1r181 UTSW 7 23,684,356 (GRCm39) missense probably benign 0.01
R7972:Vmn1r181 UTSW 7 23,683,871 (GRCm39) missense probably benign 0.30
R8465:Vmn1r181 UTSW 7 23,684,309 (GRCm39) missense possibly damaging 0.65
R9096:Vmn1r181 UTSW 7 23,684,444 (GRCm39) missense probably benign 0.00
R9097:Vmn1r181 UTSW 7 23,684,444 (GRCm39) missense probably benign 0.00
X0067:Vmn1r181 UTSW 7 23,684,326 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACATAGCTGTGGCCAATGC -3'
(R):5'- TGTGGCATCATGGGCAAATCG -3'

Sequencing Primer
(F):5'- AATGCCTTGACTCTCTTCATCACTAC -3'
(R):5'- GAAGACAATACCCACATTAAATCCAG -3'
Posted On 2015-03-18