Incidental Mutation 'R3757:Layn'
ID 271482
Institutional Source Beutler Lab
Gene Symbol Layn
Ensembl Gene ENSMUSG00000060594
Gene Name layilin
Synonyms LOC244864, E030012M19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R3757 (G1)
Quality Score 202
Status Validated
Chromosome 9
Chromosomal Location 50966323-50988501 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50970856 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 229 (E229G)
Ref Sequence ENSEMBL: ENSMUSP00000150681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098782] [ENSMUST00000214452] [ENSMUST00000217212]
AlphaFold Q8C351
Predicted Effect probably benign
Transcript: ENSMUST00000098782
AA Change: E229G

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000096379
Gene: ENSMUSG00000060594
AA Change: E229G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
CLECT 41 185 6.18e-25 SMART
transmembrane domain 237 259 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214452
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216453
Predicted Effect probably benign
Transcript: ENSMUST00000217212
AA Change: E229G

PolyPhen 2 Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.0902 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Layn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00921:Layn APN 9 50,968,708 (GRCm39) missense probably damaging 1.00
IGL01145:Layn APN 9 50,985,346 (GRCm39) missense probably benign 0.01
IGL02006:Layn APN 9 50,968,591 (GRCm39) intron probably benign
IGL02226:Layn APN 9 50,985,317 (GRCm39) missense probably damaging 1.00
PIT4677001:Layn UTSW 9 50,968,711 (GRCm39) missense probably damaging 0.98
R1464:Layn UTSW 9 50,968,886 (GRCm39) missense probably damaging 1.00
R1464:Layn UTSW 9 50,968,886 (GRCm39) missense probably damaging 1.00
R1775:Layn UTSW 9 50,970,833 (GRCm39) missense probably benign 0.03
R2156:Layn UTSW 9 50,968,697 (GRCm39) missense probably benign
R3732:Layn UTSW 9 50,970,844 (GRCm39) missense probably damaging 1.00
R3732:Layn UTSW 9 50,970,844 (GRCm39) missense probably damaging 1.00
R3733:Layn UTSW 9 50,970,844 (GRCm39) missense probably damaging 1.00
R4840:Layn UTSW 9 50,968,682 (GRCm39) missense probably damaging 1.00
R5792:Layn UTSW 9 50,979,461 (GRCm39) missense probably damaging 1.00
R7185:Layn UTSW 9 50,985,173 (GRCm39) missense possibly damaging 0.58
R7216:Layn UTSW 9 50,988,352 (GRCm39) start gained probably benign
R7404:Layn UTSW 9 50,968,670 (GRCm39) missense possibly damaging 0.94
R8784:Layn UTSW 9 50,970,781 (GRCm39) missense possibly damaging 0.60
R9228:Layn UTSW 9 50,968,837 (GRCm39) missense probably damaging 1.00
R9248:Layn UTSW 9 50,968,760 (GRCm39) missense possibly damaging 0.48
R9725:Layn UTSW 9 50,968,775 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTCATGGCCTTTAATGATGCC -3'
(R):5'- ACTGCATCTATCTCCTAGAATGTGC -3'

Sequencing Primer
(F):5'- GCCTTTAATGATGCCAGCCAG -3'
(R):5'- TCTATCTCCTAGAATGTGCTGTTTAG -3'
Posted On 2015-03-18