Incidental Mutation 'R3757:Or6c207'
ID 271485
Institutional Source Beutler Lab
Gene Symbol Or6c207
Ensembl Gene ENSMUSG00000062914
Gene Name olfactory receptor family 6 subfamily C member 207
Synonyms Olfr777, MOR114-9, GA_x6K02T2PULF-10955551-10954616
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R3757 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129104255-129105190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129104934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 86 (D86G)
Ref Sequence ENSEMBL: ENSMUSP00000145475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080313] [ENSMUST00000204573] [ENSMUST00000213512]
AlphaFold Q8VFH3
Predicted Effect probably damaging
Transcript: ENSMUST00000080313
AA Change: D86G

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000079191
Gene: ENSMUSG00000062914
AA Change: D86G

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204573
AA Change: D86G

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145475
Gene: ENSMUSG00000062914
AA Change: D86G

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213512
Meta Mutation Damage Score 0.1812 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Or6c207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01302:Or6c207 APN 10 129,104,392 (GRCm39) missense probably benign 0.18
IGL01782:Or6c207 APN 10 129,104,908 (GRCm39) missense probably benign 0.00
R0554:Or6c207 UTSW 10 129,104,368 (GRCm39) missense probably benign 0.00
R0594:Or6c207 UTSW 10 129,105,021 (GRCm39) missense possibly damaging 0.95
R1792:Or6c207 UTSW 10 129,105,112 (GRCm39) missense probably benign 0.20
R2357:Or6c207 UTSW 10 129,104,642 (GRCm39) missense probably benign 0.31
R2426:Or6c207 UTSW 10 129,105,135 (GRCm39) missense probably benign 0.00
R3758:Or6c207 UTSW 10 129,104,934 (GRCm39) missense probably damaging 0.99
R3962:Or6c207 UTSW 10 129,104,535 (GRCm39) missense probably damaging 1.00
R4600:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4603:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4611:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R5113:Or6c207 UTSW 10 129,104,535 (GRCm39) missense probably damaging 0.98
R6415:Or6c207 UTSW 10 129,104,890 (GRCm39) missense probably benign 0.01
R7540:Or6c207 UTSW 10 129,105,003 (GRCm39) missense probably benign 0.31
R7909:Or6c207 UTSW 10 129,105,136 (GRCm39) missense probably benign 0.00
R8170:Or6c207 UTSW 10 129,104,917 (GRCm39) missense possibly damaging 0.80
R9079:Or6c207 UTSW 10 129,104,466 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- CCAGCAACTGAGGATAAGTCTTG -3'
(R):5'- GACTGACGGATGATCCACAAC -3'

Sequencing Primer
(F):5'- CTGAGGATAAGTCTTGCACAGATCC -3'
(R):5'- GGATGATCCACAACTGAAAACTCTG -3'
Posted On 2015-03-18