Incidental Mutation 'R3757:H1f4'
ID 271490
Institutional Source Beutler Lab
Gene Symbol H1f4
Ensembl Gene ENSMUSG00000051627
Gene Name H1.4 linker histone, cluster member
Synonyms H1f4, H1-4, H1e, H1var2, Hist1h1e, H1s-4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3757 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 23805760-23806541 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 23806240 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 81 (K81*)
Ref Sequence ENSEMBL: ENSMUSP00000057308 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051091] [ENSMUST00000062045] [ENSMUST00000091704]
AlphaFold P43274
Predicted Effect probably benign
Transcript: ENSMUST00000051091
SMART Domains Protein: ENSMUSP00000061247
Gene: ENSMUSG00000047246

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 1.43e-72 SMART
Predicted Effect probably null
Transcript: ENSMUST00000062045
AA Change: K81*
SMART Domains Protein: ENSMUSP00000057308
Gene: ENSMUSG00000051627
AA Change: K81*

DomainStartEndE-ValueType
low complexity region 5 15 N/A INTRINSIC
H15 34 99 7.5e-23 SMART
low complexity region 116 219 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000091704
SMART Domains Protein: ENSMUSP00000089296
Gene: ENSMUSG00000047246

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 1.43e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120330
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129312
Meta Mutation Damage Score 0.9653 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
MGI Phenotype FUNCTION: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
PHENOTYPE: Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in H1f4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:H1f4 APN 13 23,806,005 (GRCm39) unclassified probably benign
IGL03354:H1f4 APN 13 23,806,060 (GRCm39) unclassified probably benign
PIT4469001:H1f4 UTSW 13 23,806,362 (GRCm39) missense probably damaging 1.00
R2339:H1f4 UTSW 13 23,805,943 (GRCm39) unclassified probably benign
R3110:H1f4 UTSW 13 23,805,829 (GRCm39) unclassified probably benign
R3112:H1f4 UTSW 13 23,805,829 (GRCm39) unclassified probably benign
R3758:H1f4 UTSW 13 23,806,240 (GRCm39) nonsense probably null
R5116:H1f4 UTSW 13 23,806,270 (GRCm39) missense probably damaging 1.00
R6034:H1f4 UTSW 13 23,806,296 (GRCm39) missense probably damaging 1.00
R6034:H1f4 UTSW 13 23,806,296 (GRCm39) missense probably damaging 1.00
R7008:H1f4 UTSW 13 23,806,192 (GRCm39) missense probably damaging 1.00
R7051:H1f4 UTSW 13 23,806,422 (GRCm39) missense probably benign 0.00
R7317:H1f4 UTSW 13 23,806,350 (GRCm39) missense probably damaging 1.00
R8220:H1f4 UTSW 13 23,805,922 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- GCAGCTGGCTTCTTCGCTTT -3'
(R):5'- TCAAGAAGAAGGCCCGCAAG -3'

Sequencing Primer
(F):5'- CCCGCAGCCTTCTTGGG -3'
(R):5'- AACTCATCACCAAGGCTG -3'
Posted On 2015-03-18