Incidental Mutation 'R3757:Cage1'
ID 271491
Institutional Source Beutler Lab
Gene Symbol Cage1
Ensembl Gene ENSMUSG00000044566
Gene Name cancer antigen 1
Synonyms Ctag3, CAGE1, 4933427I01Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R3757 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 38190028-38221045 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 38209705 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 91 (F91V)
Ref Sequence ENSEMBL: ENSMUSP00000122393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074969] [ENSMUST00000089840] [ENSMUST00000110233] [ENSMUST00000131066]
AlphaFold Q5IR70
Predicted Effect possibly damaging
Transcript: ENSMUST00000074969
AA Change: F91V

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000074499
Gene: ENSMUSG00000044566
AA Change: F91V

DomainStartEndE-ValueType
Pfam:CAGE1 1 526 5.1e-292 PFAM
low complexity region 664 682 N/A INTRINSIC
coiled coil region 778 811 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000089840
SMART Domains Protein: ENSMUSP00000087278
Gene: ENSMUSG00000044566

DomainStartEndE-ValueType
Pfam:CAGE1 1 420 6.8e-230 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000110233
AA Change: F91V

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000105862
Gene: ENSMUSG00000044566
AA Change: F91V

DomainStartEndE-ValueType
Pfam:CAGE1 1 526 2.4e-255 PFAM
low complexity region 664 682 N/A INTRINSIC
coiled coil region 778 811 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000131066
AA Change: F91V

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000122393
Gene: ENSMUSG00000044566
AA Change: F91V

DomainStartEndE-ValueType
Pfam:CAGE1 1 318 6.5e-167 PFAM
Meta Mutation Damage Score 0.1466 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Cage1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00648:Cage1 APN 13 38,206,969 (GRCm39) nonsense probably null
IGL01736:Cage1 APN 13 38,206,789 (GRCm39) missense possibly damaging 0.93
IGL02149:Cage1 APN 13 38,206,505 (GRCm39) missense probably damaging 1.00
IGL02267:Cage1 APN 13 38,207,233 (GRCm39) missense probably damaging 1.00
IGL03030:Cage1 APN 13 38,212,123 (GRCm39) missense probably benign
IGL03216:Cage1 APN 13 38,190,153 (GRCm39) splice site probably benign
R0487:Cage1 UTSW 13 38,209,334 (GRCm39) missense probably benign 0.00
R0606:Cage1 UTSW 13 38,200,470 (GRCm39) splice site probably benign
R1015:Cage1 UTSW 13 38,200,451 (GRCm39) missense possibly damaging 0.96
R1170:Cage1 UTSW 13 38,206,856 (GRCm39) missense probably damaging 1.00
R1400:Cage1 UTSW 13 38,216,400 (GRCm39) missense possibly damaging 0.86
R1721:Cage1 UTSW 13 38,207,309 (GRCm39) nonsense probably null
R2057:Cage1 UTSW 13 38,207,356 (GRCm39) missense probably benign 0.04
R2058:Cage1 UTSW 13 38,207,356 (GRCm39) missense probably benign 0.04
R2059:Cage1 UTSW 13 38,207,356 (GRCm39) missense probably benign 0.04
R2197:Cage1 UTSW 13 38,207,029 (GRCm39) missense probably damaging 1.00
R3758:Cage1 UTSW 13 38,209,705 (GRCm39) missense possibly damaging 0.71
R4041:Cage1 UTSW 13 38,203,153 (GRCm39) missense possibly damaging 0.96
R4370:Cage1 UTSW 13 38,209,626 (GRCm39) missense probably damaging 1.00
R4401:Cage1 UTSW 13 38,207,078 (GRCm39) missense probably damaging 1.00
R4402:Cage1 UTSW 13 38,207,078 (GRCm39) missense probably damaging 1.00
R4403:Cage1 UTSW 13 38,207,078 (GRCm39) missense probably damaging 1.00
R4490:Cage1 UTSW 13 38,207,393 (GRCm39) missense possibly damaging 0.86
R4621:Cage1 UTSW 13 38,209,477 (GRCm39) missense possibly damaging 0.85
R4921:Cage1 UTSW 13 38,203,184 (GRCm39) missense probably benign 0.33
R4950:Cage1 UTSW 13 38,207,302 (GRCm39) missense possibly damaging 0.55
R4953:Cage1 UTSW 13 38,207,406 (GRCm39) missense possibly damaging 0.51
R5023:Cage1 UTSW 13 38,195,387 (GRCm39) nonsense probably null
R5808:Cage1 UTSW 13 38,206,301 (GRCm39) unclassified probably benign
R5845:Cage1 UTSW 13 38,199,682 (GRCm39) missense probably damaging 0.96
R6278:Cage1 UTSW 13 38,200,395 (GRCm39) missense possibly damaging 0.53
R6503:Cage1 UTSW 13 38,209,425 (GRCm39) missense possibly damaging 0.73
R6882:Cage1 UTSW 13 38,206,534 (GRCm39) missense probably damaging 1.00
R7146:Cage1 UTSW 13 38,207,025 (GRCm39) missense probably benign 0.03
R7192:Cage1 UTSW 13 38,203,220 (GRCm39) missense probably benign
R7529:Cage1 UTSW 13 38,209,731 (GRCm39) missense possibly damaging 0.71
R7580:Cage1 UTSW 13 38,206,700 (GRCm39) missense possibly damaging 0.90
R7646:Cage1 UTSW 13 38,206,823 (GRCm39) missense probably damaging 1.00
R7837:Cage1 UTSW 13 38,206,381 (GRCm39) missense not run
R8355:Cage1 UTSW 13 38,203,225 (GRCm39) missense probably damaging 0.99
R8435:Cage1 UTSW 13 38,203,161 (GRCm39) missense possibly damaging 0.73
R8466:Cage1 UTSW 13 38,206,987 (GRCm39) missense probably damaging 1.00
R9047:Cage1 UTSW 13 38,201,338 (GRCm39) missense possibly damaging 0.85
R9086:Cage1 UTSW 13 38,206,898 (GRCm39) missense probably damaging 1.00
R9146:Cage1 UTSW 13 38,207,005 (GRCm39) missense probably benign 0.16
R9442:Cage1 UTSW 13 38,196,447 (GRCm39) missense possibly damaging 0.72
R9587:Cage1 UTSW 13 38,207,233 (GRCm39) missense probably damaging 1.00
R9608:Cage1 UTSW 13 38,195,371 (GRCm39) missense possibly damaging 0.73
R9612:Cage1 UTSW 13 38,216,351 (GRCm39) missense probably damaging 0.99
R9630:Cage1 UTSW 13 38,206,855 (GRCm39) missense probably damaging 1.00
R9690:Cage1 UTSW 13 38,203,141 (GRCm39) critical splice donor site probably null
R9736:Cage1 UTSW 13 38,207,393 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGAAATGCTACTTTCCACTGAAC -3'
(R):5'- GGCTATCTTGAGATCAATAGAAGATGC -3'

Sequencing Primer
(F):5'- AACTTTCTTCCTTAAATGGATCTGGC -3'
(R):5'- AACTGTAACAGTTGTTCTGT -3'
Posted On 2015-03-18