Incidental Mutation 'R3757:Arhgap31'
ID 271499
Institutional Source Beutler Lab
Gene Symbol Arhgap31
Ensembl Gene ENSMUSG00000022799
Gene Name Rho GTPase activating protein 31
Synonyms CdGAP
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.270) question?
Stock # R3757 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 38418705-38533397 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38457362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 82 (E82G)
Ref Sequence ENSEMBL: ENSMUSP00000023487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023487]
AlphaFold A6X8Z5
Predicted Effect probably damaging
Transcript: ENSMUST00000023487
AA Change: E82G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000023487
Gene: ENSMUSG00000022799
AA Change: E82G

DomainStartEndE-ValueType
RhoGAP 32 213 1.04e-60 SMART
low complexity region 291 303 N/A INTRINSIC
low complexity region 503 522 N/A INTRINSIC
low complexity region 670 683 N/A INTRINSIC
low complexity region 722 733 N/A INTRINSIC
low complexity region 766 786 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124866
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132697
Meta Mutation Damage Score 0.1902 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or5v1b T A 17: 37,841,246 (GRCm39) I126N probably damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Arhgap31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00741:Arhgap31 APN 16 38,423,363 (GRCm39) missense probably damaging 1.00
IGL01062:Arhgap31 APN 16 38,421,818 (GRCm39) missense probably damaging 1.00
IGL01152:Arhgap31 APN 16 38,422,601 (GRCm39) missense possibly damaging 0.49
IGL01680:Arhgap31 APN 16 38,423,976 (GRCm39) missense probably benign 0.04
IGL01739:Arhgap31 APN 16 38,423,793 (GRCm39) missense probably benign
IGL01870:Arhgap31 APN 16 38,438,604 (GRCm39) missense probably damaging 1.00
IGL01936:Arhgap31 APN 16 38,423,287 (GRCm39) missense probably damaging 1.00
IGL01981:Arhgap31 APN 16 38,421,935 (GRCm39) missense probably damaging 1.00
IGL01983:Arhgap31 APN 16 38,422,127 (GRCm39) missense probably damaging 1.00
IGL02157:Arhgap31 APN 16 38,444,263 (GRCm39) missense probably damaging 1.00
IGL02629:Arhgap31 APN 16 38,429,526 (GRCm39) missense probably benign 0.00
IGL03375:Arhgap31 APN 16 38,423,190 (GRCm39) missense probably damaging 1.00
PIT4283001:Arhgap31 UTSW 16 38,429,354 (GRCm39) missense probably damaging 1.00
R0271:Arhgap31 UTSW 16 38,422,872 (GRCm39) missense possibly damaging 0.61
R1325:Arhgap31 UTSW 16 38,423,304 (GRCm39) missense probably benign 0.00
R1753:Arhgap31 UTSW 16 38,421,974 (GRCm39) missense possibly damaging 0.92
R1766:Arhgap31 UTSW 16 38,445,952 (GRCm39) missense probably damaging 1.00
R1834:Arhgap31 UTSW 16 38,424,065 (GRCm39) missense probably benign 0.02
R2104:Arhgap31 UTSW 16 38,445,941 (GRCm39) missense probably benign 0.03
R2261:Arhgap31 UTSW 16 38,429,639 (GRCm39) missense probably damaging 1.00
R3011:Arhgap31 UTSW 16 38,422,269 (GRCm39) missense possibly damaging 0.58
R3712:Arhgap31 UTSW 16 38,422,895 (GRCm39) missense possibly damaging 0.91
R3953:Arhgap31 UTSW 16 38,423,826 (GRCm39) missense probably benign 0.00
R4105:Arhgap31 UTSW 16 38,422,788 (GRCm39) missense probably damaging 1.00
R4107:Arhgap31 UTSW 16 38,422,788 (GRCm39) missense probably damaging 1.00
R4108:Arhgap31 UTSW 16 38,422,788 (GRCm39) missense probably damaging 1.00
R4109:Arhgap31 UTSW 16 38,422,788 (GRCm39) missense probably damaging 1.00
R4198:Arhgap31 UTSW 16 38,444,275 (GRCm39) missense probably damaging 1.00
R4200:Arhgap31 UTSW 16 38,444,275 (GRCm39) missense probably damaging 1.00
R4273:Arhgap31 UTSW 16 38,422,697 (GRCm39) missense possibly damaging 0.92
R5020:Arhgap31 UTSW 16 38,423,438 (GRCm39) missense probably damaging 1.00
R5100:Arhgap31 UTSW 16 38,421,821 (GRCm39) missense probably damaging 1.00
R6516:Arhgap31 UTSW 16 38,429,766 (GRCm39) missense possibly damaging 0.47
R6879:Arhgap31 UTSW 16 38,422,676 (GRCm39) missense probably benign
R7341:Arhgap31 UTSW 16 38,532,876 (GRCm39) splice site probably null
R7880:Arhgap31 UTSW 16 38,423,087 (GRCm39) missense probably benign 0.37
R7884:Arhgap31 UTSW 16 38,422,593 (GRCm39) missense probably damaging 0.97
R8156:Arhgap31 UTSW 16 38,445,991 (GRCm39) missense probably damaging 1.00
R8223:Arhgap31 UTSW 16 38,424,084 (GRCm39) missense probably benign 0.21
R8413:Arhgap31 UTSW 16 38,423,283 (GRCm39) missense possibly damaging 0.76
R8545:Arhgap31 UTSW 16 38,423,408 (GRCm39) missense probably damaging 0.98
R8679:Arhgap31 UTSW 16 38,422,966 (GRCm39) missense probably damaging 0.97
R8721:Arhgap31 UTSW 16 38,427,058 (GRCm39) missense probably benign
R8815:Arhgap31 UTSW 16 38,429,790 (GRCm39) missense probably benign
R9056:Arhgap31 UTSW 16 38,427,017 (GRCm39) missense probably benign 0.00
R9077:Arhgap31 UTSW 16 38,422,730 (GRCm39) missense probably damaging 0.98
R9251:Arhgap31 UTSW 16 38,423,218 (GRCm39) missense probably benign
R9382:Arhgap31 UTSW 16 38,422,988 (GRCm39) missense probably benign 0.14
R9500:Arhgap31 UTSW 16 38,460,683 (GRCm39) missense probably damaging 1.00
R9544:Arhgap31 UTSW 16 38,423,976 (GRCm39) missense probably damaging 0.99
X0063:Arhgap31 UTSW 16 38,422,760 (GRCm39) missense probably damaging 0.99
Z1176:Arhgap31 UTSW 16 38,444,255 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TTATTTCAGTGTCGAAACTGCC -3'
(R):5'- ATCAGCCTCCAAAAGCGGTG -3'

Sequencing Primer
(F):5'- AGTGTCGAAACTGCCCTTGG -3'
(R):5'- AAAGCGGTGTCTCTCCAATG -3'
Posted On 2015-03-18