Incidental Mutation 'R3757:Or5v1b'
ID 271502
Institutional Source Beutler Lab
Gene Symbol Or5v1b
Ensembl Gene ENSMUSG00000090675
Gene Name olfactory receptor family 5 subfamily V member 1B
Synonyms MOR249-1P, GA_x6K02T2PSCP-1989071-1990024, Olfr111
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.499) question?
Stock # R3757 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 37818921-37843340 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37841246 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 126 (I126N)
Ref Sequence ENSEMBL: ENSMUSP00000150806 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097325] [ENSMUST00000214259] [ENSMUST00000215424]
AlphaFold Q7TRK1
Predicted Effect probably damaging
Transcript: ENSMUST00000097325
AA Change: I126N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000094933
Gene: ENSMUSG00000090675
AA Change: I126N

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.4e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 302 1.5e-5 PFAM
Pfam:7tm_1 41 290 1.4e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214259
AA Change: I126N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215424
AA Change: I126N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 92% (35/38)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T A 7: 81,986,415 (GRCm39) I9K probably benign Het
Arhgap31 T C 16: 38,457,362 (GRCm39) E82G probably damaging Het
Asap2 T A 12: 21,317,767 (GRCm39) S993T probably damaging Het
Bmpr1a A T 14: 34,156,624 (GRCm39) L134* probably null Het
Cacna1e A G 1: 154,509,442 (GRCm39) V271A probably damaging Het
Cacna2d4 A G 6: 119,218,124 (GRCm39) E153G probably damaging Het
Cage1 A C 13: 38,209,705 (GRCm39) F91V possibly damaging Het
Cdh24 T C 14: 54,869,637 (GRCm39) D760G possibly damaging Het
Col9a1 T C 1: 24,271,312 (GRCm39) probably null Het
Cts6 A T 13: 61,349,972 (GRCm39) Y36* probably null Het
Dennd3 C G 15: 73,394,083 (GRCm39) A36G probably benign Het
Dmxl1 G A 18: 50,068,384 (GRCm39) G2719D probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Ep300 T A 15: 81,532,790 (GRCm39) V1676E unknown Het
Ercc4 C T 16: 12,962,360 (GRCm39) T668M probably benign Het
G530012D18Rik CAGAGAGA CAGAGAGAGA 1: 85,504,945 (GRCm39) probably null Het
Gm10985 GCTCTCTCTCTCTCTCTCTCTCTCTCTCT GCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT 3: 53,752,645 (GRCm39) probably null Het
H1f4 T A 13: 23,806,240 (GRCm39) K81* probably null Het
Havcr1 G T 11: 46,643,407 (GRCm39) R109L probably damaging Het
Krtap4-9 A G 11: 99,676,444 (GRCm39) probably benign Het
Layn T C 9: 50,970,856 (GRCm39) E229G probably benign Het
Lpcat3 T A 6: 124,676,955 (GRCm39) probably null Het
Lrrn1 T A 6: 107,546,169 (GRCm39) F656I possibly damaging Het
Lypd1 A G 1: 125,838,121 (GRCm39) probably benign Het
Or4k41 T A 2: 111,279,602 (GRCm39) V39E possibly damaging Het
Or6c207 T C 10: 129,104,934 (GRCm39) D86G probably damaging Het
Ptprt A T 2: 161,653,950 (GRCm39) L560Q probably damaging Het
Rbm11 T C 16: 75,393,469 (GRCm39) V55A probably damaging Het
Scn11a C T 9: 119,632,569 (GRCm39) V434I probably benign Het
Serpinc1 A G 1: 160,829,935 (GRCm39) T434A probably benign Het
Setd2 T C 9: 110,402,753 (GRCm39) I1798T probably damaging Het
Sfswap A G 5: 129,590,298 (GRCm39) Y265C probably damaging Het
Slc9a8 C A 2: 167,266,050 (GRCm39) T9K probably benign Het
Synpo T C 18: 60,736,062 (GRCm39) D389G probably damaging Het
Vmn1r181 C T 7: 23,683,909 (GRCm39) L125F possibly damaging Het
Wdfy4 A C 14: 32,745,331 (GRCm39) H2296Q probably benign Het
Other mutations in Or5v1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01870:Or5v1b APN 17 37,841,555 (GRCm39) missense probably benign 0.00
IGL02472:Or5v1b APN 17 37,841,640 (GRCm39) missense probably damaging 1.00
IGL02511:Or5v1b APN 17 37,840,870 (GRCm39) start codon destroyed probably null 0.99
BB009:Or5v1b UTSW 17 37,841,075 (GRCm39) missense probably benign 0.31
BB019:Or5v1b UTSW 17 37,841,075 (GRCm39) missense probably benign 0.31
R0335:Or5v1b UTSW 17 37,841,533 (GRCm39) missense probably benign 0.01
R2006:Or5v1b UTSW 17 37,841,597 (GRCm39) missense probably damaging 1.00
R4167:Or5v1b UTSW 17 37,840,897 (GRCm39) missense possibly damaging 0.65
R4904:Or5v1b UTSW 17 37,841,522 (GRCm39) missense probably damaging 1.00
R4952:Or5v1b UTSW 17 37,841,641 (GRCm39) missense possibly damaging 0.48
R7366:Or5v1b UTSW 17 37,841,708 (GRCm39) missense probably damaging 0.99
R7389:Or5v1b UTSW 17 37,841,548 (GRCm39) missense possibly damaging 0.72
R7510:Or5v1b UTSW 17 37,841,480 (GRCm39) missense probably damaging 0.98
R7932:Or5v1b UTSW 17 37,841,075 (GRCm39) missense probably benign 0.31
R8080:Or5v1b UTSW 17 37,841,555 (GRCm39) missense probably benign 0.00
R8326:Or5v1b UTSW 17 37,841,470 (GRCm39) missense probably benign 0.19
R8828:Or5v1b UTSW 17 37,841,333 (GRCm39) missense probably damaging 1.00
R9275:Or5v1b UTSW 17 37,841,819 (GRCm39) missense probably benign 0.01
R9779:Or5v1b UTSW 17 37,841,048 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGACCATAGCTGATTCCCACC -3'
(R):5'- ATGGACAGCAAAGCCAGTTC -3'

Sequencing Primer
(F):5'- GGAAATCTTGCCCTTATTGACATCTG -3'
(R):5'- CCAGTTCATTGAGGGAAGTATCACC -3'
Posted On 2015-03-18