Incidental Mutation 'R3723:Gm8603'
Institutional Source Beutler Lab
Gene Symbol Gm8603
Ensembl Gene ENSMUSG00000060417
Gene Namepredicted gene 8603
MMRRC Submission 040714-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.116) question?
Stock #R3723 (G1)
Quality Score225
Status Validated
Chromosomal Location13516755-13518269 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to C at 13516813 bp
Amino Acid Change
Gene Model predicted gene model for transcript(s):
Predicted Effect probably null
Transcript: ENSMUST00000074512
SMART Domains Protein: ENSMUSP00000074106
Gene: ENSMUSG00000060417

S_TKc 8 256 5.81e-84 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000115649
SMART Domains Protein: ENSMUSP00000111313
Gene: ENSMUSG00000079711

S_TKc 8 256 2.17e-83 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135850
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137459
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144015
SMART Domains Protein: ENSMUSP00000119597
Gene: ENSMUSG00000079711

S_TKc 8 256 2.17e-83 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185626
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 95% (38/40)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T C 19: 9,016,853 V5167A possibly damaging Het
Ano5 A G 7: 51,576,528 Y510C probably damaging Het
Api5 C T 2: 94,425,613 R243Q possibly damaging Het
Apob A T 12: 8,006,327 Q1570L probably damaging Het
Apob A G 12: 8,011,763 N3415S possibly damaging Het
Arsk T A 13: 76,066,653 I361F probably damaging Het
C9 G A 15: 6,483,080 E228K possibly damaging Het
Celsr2 A G 3: 108,397,415 probably benign Het
Cfap53 A G 18: 74,359,569 I455V probably benign Het
Ckap4 A G 10: 84,528,392 L269P probably damaging Het
Dnah7a T A 1: 53,447,346 D3352V probably benign Het
Dync2h1 A T 9: 7,041,658 M3335K probably benign Het
Fam171a1 A G 2: 3,220,375 probably benign Het
Glis3 A T 19: 28,262,591 C97* probably null Het
Gm13101 T C 4: 143,966,681 T76A probably benign Het
Gm14221 C G 2: 160,568,427 noncoding transcript Het
Gm9767 G T 10: 26,078,571 probably benign Het
Kctd16 A G 18: 40,258,859 T167A possibly damaging Het
Kif18b A G 11: 102,916,276 F78L probably damaging Het
Mefv A G 16: 3,708,194 probably null Het
Mipol1 C A 12: 57,457,092 L349I probably damaging Het
Myo10 T C 15: 25,803,288 V1527A probably damaging Het
Naip5 G T 13: 100,223,014 Y571* probably null Het
Npl A G 1: 153,515,464 F182L probably benign Het
Pan3 T A 5: 147,503,208 probably benign Het
Pcdh15 A T 10: 74,645,848 T342S probably benign Het
Pcdhga1 A G 18: 37,662,992 T350A possibly damaging Het
Prdm4 A G 10: 85,899,281 S666P probably damaging Het
Rere A G 4: 150,468,795 E148G probably damaging Het
Scube2 T C 7: 109,808,406 probably benign Het
Sptbn1 A G 11: 30,137,335 S1035P possibly damaging Het
Srsf4 C T 4: 131,900,102 probably benign Het
Supt3 A G 17: 44,994,387 D108G probably damaging Het
Tnfsf13b A G 8: 10,031,545 I236V possibly damaging Het
Tns1 T C 1: 73,924,940 S1511G probably damaging Het
Tpm1 G A 9: 67,031,945 probably benign Het
Uba6 T C 5: 86,135,047 D559G probably damaging Het
Vmn1r117 T A 7: 20,883,455 I223F probably damaging Het
Vmn2r91 G A 17: 18,085,278 probably null Het
Zfp30 A G 7: 29,793,353 E344G probably damaging Het
Other mutations in Gm8603
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02170:Gm8603 APN 17 13516811 intron noncoding transcript
R4659:Gm8603 UTSW 17 13517028 intron noncoding transcript
Predicted Primers PCR Primer

Sequencing Primer
Posted On2015-03-18