Incidental Mutation 'R1536:Stk35'
ID 271575
Institutional Source Beutler Lab
Gene Symbol Stk35
Ensembl Gene ENSMUSG00000037885
Gene Name serine/threonine kinase 35
Synonyms 1700054C12Rik, CLIK1, CLP-36 interacting kinase
MMRRC Submission 039575-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1536 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 129800517-129832287 bp(+) (GRCm38)
Type of Mutation intron
DNA Base Change (assembly) T to C at 129811235 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132862 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165413] [ENSMUST00000166282]
AlphaFold Q80ZW0
Predicted Effect probably benign
Transcript: ENSMUST00000165413
SMART Domains Protein: ENSMUSP00000126541
Gene: ENSMUSG00000037885

DomainStartEndE-ValueType
low complexity region 51 69 N/A INTRINSIC
low complexity region 115 137 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:Pkinase_Tyr 207 295 2e-6 PFAM
Pfam:Pkinase 207 531 8.6e-51 PFAM
Pfam:Pkinase_Tyr 304 532 2.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166282
SMART Domains Protein: ENSMUSP00000132862
Gene: ENSMUSG00000037885

DomainStartEndE-ValueType
low complexity region 51 69 N/A INTRINSIC
low complexity region 115 137 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:Pkinase_Tyr 207 300 5.9e-7 PFAM
Pfam:Pkinase 207 311 1e-9 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.5%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A T 5: 87,970,665 (GRCm38) I3F probably benign Het
4930590J08Rik A G 6: 91,917,035 (GRCm38) N211S probably benign Het
A2ml1 A T 6: 128,547,233 (GRCm38) Y1145* probably null Het
Abca7 A G 10: 80,014,230 (GRCm38) D1972G probably benign Het
Adamts19 A T 18: 59,052,615 (GRCm38) D1187V probably damaging Het
Adcy6 G C 15: 98,600,007 (GRCm38) I421M probably damaging Het
Afap1 C A 5: 35,974,491 (GRCm38) H387Q probably damaging Het
Atp8b1 C T 18: 64,545,264 (GRCm38) V854M probably damaging Het
Auts2 C T 5: 131,487,463 (GRCm38) probably benign Het
Cbll1 T C 12: 31,487,856 (GRCm38) D300G probably damaging Het
Cd200r4 A T 16: 44,833,049 (GRCm38) T61S possibly damaging Het
Chmp4c G T 3: 10,389,684 (GRCm38) V207L probably benign Het
Cntn5 T C 9: 9,976,316 (GRCm38) T413A possibly damaging Het
Cox7a2 T A 9: 79,758,581 (GRCm38) probably null Het
Cwc27 A G 13: 104,797,306 (GRCm38) L236P probably damaging Het
Diaph1 A G 18: 37,896,093 (GRCm38) probably null Het
Dst T A 1: 34,260,372 (GRCm38) probably benign Het
Ear1 T A 14: 43,819,126 (GRCm38) H95L probably damaging Het
Enpp1 T A 10: 24,641,834 (GRCm38) H898L probably benign Het
Entpd5 G A 12: 84,382,295 (GRCm38) R321* probably null Het
Ercc6l2 C A 13: 63,824,871 (GRCm38) N177K possibly damaging Het
Ergic1 T C 17: 26,641,706 (GRCm38) probably null Het
Erich6 A T 3: 58,626,598 (GRCm38) I336N probably benign Het
Fmnl2 A G 2: 53,105,537 (GRCm38) E424G probably damaging Het
Galnt3 A T 2: 66,084,206 (GRCm38) D622E probably damaging Het
Gjd4 T A 18: 9,280,569 (GRCm38) T170S probably damaging Het
Gm5611 G A 9: 17,030,607 (GRCm38) noncoding transcript Het
Gpc5 T A 14: 115,399,250 (GRCm38) N448K probably benign Het
Klra3 G C 6: 130,333,144 (GRCm38) R138G probably benign Het
Maco1 A G 4: 134,804,507 (GRCm38) V617A probably damaging Het
Man2b2 T C 5: 36,820,927 (GRCm38) T338A probably benign Het
Mbtps1 A T 8: 119,546,125 (GRCm38) S94T probably benign Het
Muc3a A T 5: 137,210,081 (GRCm38) S205T unknown Het
Nav2 C A 7: 49,545,934 (GRCm38) D1019E probably damaging Het
Neurl4 T A 11: 69,903,426 (GRCm38) L236* probably null Het
Or13c25 A G 4: 52,911,260 (GRCm38) V178A probably benign Het
Plcxd3 T C 15: 4,516,611 (GRCm38) probably benign Het
Pprc1 T C 19: 46,071,526 (GRCm38) probably benign Het
Prkaa2 T A 4: 105,075,450 (GRCm38) N67I probably damaging Het
Prom1 T A 5: 44,018,353 (GRCm38) Y508F probably benign Het
Prx A G 7: 27,517,258 (GRCm38) M534V probably damaging Het
Rps6kc1 C T 1: 190,871,768 (GRCm38) R219Q possibly damaging Het
Sbf2 T C 7: 110,378,043 (GRCm38) Y628C probably damaging Het
Slc1a2 A T 2: 102,777,510 (GRCm38) D501V probably benign Het
Spata31 A T 13: 64,921,382 (GRCm38) Q448L probably damaging Het
Stxbp5 T A 10: 9,838,092 (GRCm38) R234S probably damaging Het
Tifab A G 13: 56,176,288 (GRCm38) V114A probably benign Het
Tiprl A G 1: 165,228,406 (GRCm38) M49T probably benign Het
Tlr12 A G 4: 128,617,752 (GRCm38) L235P possibly damaging Het
Trim43b A T 9: 89,085,358 (GRCm38) C407* probably null Het
Txndc17 C A 11: 72,207,707 (GRCm38) F28L probably damaging Het
Vmn2r27 T C 6: 124,200,690 (GRCm38) R452G probably damaging Het
Vmn2r3 T A 3: 64,275,117 (GRCm38) D387V probably damaging Het
Vps13b T C 15: 35,875,566 (GRCm38) I2699T probably damaging Het
Zfp944 G T 17: 22,339,716 (GRCm38) Y183* probably null Het
Other mutations in Stk35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00850:Stk35 APN 2 129,801,992 (GRCm38) missense probably damaging 1.00
IGL02609:Stk35 APN 2 129,801,801 (GRCm38) missense probably damaging 1.00
fingernails UTSW 2 129,810,935 (GRCm38) missense probably damaging 1.00
R2256_Stk35_331 UTSW 2 129,810,507 (GRCm38) nonsense probably null
skinned UTSW 2 129,811,235 (GRCm38) intron probably benign
R0045:Stk35 UTSW 2 129,800,568 (GRCm38) nonsense probably null
R0306:Stk35 UTSW 2 129,801,763 (GRCm38) nonsense probably null
R0784:Stk35 UTSW 2 129,810,802 (GRCm38) nonsense probably null
R2256:Stk35 UTSW 2 129,810,507 (GRCm38) nonsense probably null
R2507:Stk35 UTSW 2 129,801,515 (GRCm38) missense probably damaging 0.97
R2508:Stk35 UTSW 2 129,801,515 (GRCm38) missense probably damaging 0.97
R3848:Stk35 UTSW 2 129,800,736 (GRCm38) missense probably benign 0.13
R3872:Stk35 UTSW 2 129,810,575 (GRCm38) missense possibly damaging 0.82
R4466:Stk35 UTSW 2 129,801,516 (GRCm38) missense probably damaging 0.99
R5144:Stk35 UTSW 2 129,810,935 (GRCm38) missense probably damaging 1.00
R6267:Stk35 UTSW 2 129,810,888 (GRCm38) nonsense probably null
R6296:Stk35 UTSW 2 129,810,888 (GRCm38) nonsense probably null
R6480:Stk35 UTSW 2 129,810,687 (GRCm38) missense possibly damaging 0.95
R6807:Stk35 UTSW 2 129,801,653 (GRCm38) missense probably damaging 0.97
R7203:Stk35 UTSW 2 129,801,593 (GRCm38) missense probably benign
R7476:Stk35 UTSW 2 129,810,725 (GRCm38) missense probably damaging 1.00
R8505:Stk35 UTSW 2 129,801,729 (GRCm38) missense probably damaging 0.99
R8998:Stk35 UTSW 2 129,810,589 (GRCm38) missense probably damaging 1.00
R8999:Stk35 UTSW 2 129,810,589 (GRCm38) missense probably damaging 1.00
R9224:Stk35 UTSW 2 129,810,571 (GRCm38) missense probably damaging 1.00
R9760:Stk35 UTSW 2 129,800,685 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGGTGAGGCGCTGCTAGAAAACC -3'
(R):5'- CCATGAACAAGCAAGCACAGTTGGG -3'

Sequencing Primer
(F):5'- AAGATGGAGTTGCATATCCCC -3'
(R):5'- CTGAAGAACTTGAAAGATTCAGCCTC -3'
Posted On 2015-03-23