Incidental Mutation 'R1536:Stk35'
ID 271575
Institutional Source Beutler Lab
Gene Symbol Stk35
Ensembl Gene ENSMUSG00000037885
Gene Name serine/threonine kinase 35
Synonyms CLP-36 interacting kinase, CLIK1, 1700054C12Rik
MMRRC Submission 039575-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1536 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 129642437-129674207 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 129653155 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132862 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165413] [ENSMUST00000166282]
AlphaFold Q80ZW0
Predicted Effect probably benign
Transcript: ENSMUST00000165413
SMART Domains Protein: ENSMUSP00000126541
Gene: ENSMUSG00000037885

DomainStartEndE-ValueType
low complexity region 51 69 N/A INTRINSIC
low complexity region 115 137 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:Pkinase_Tyr 207 295 2e-6 PFAM
Pfam:Pkinase 207 531 8.6e-51 PFAM
Pfam:Pkinase_Tyr 304 532 2.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000166282
SMART Domains Protein: ENSMUSP00000132862
Gene: ENSMUSG00000037885

DomainStartEndE-ValueType
low complexity region 51 69 N/A INTRINSIC
low complexity region 115 137 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:Pkinase_Tyr 207 300 5.9e-7 PFAM
Pfam:Pkinase 207 311 1e-9 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.5%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A T 5: 88,118,524 (GRCm39) I3F probably benign Het
4930590J08Rik A G 6: 91,894,016 (GRCm39) N211S probably benign Het
A2ml1 A T 6: 128,524,196 (GRCm39) Y1145* probably null Het
Abca7 A G 10: 79,850,064 (GRCm39) D1972G probably benign Het
Adamts19 A T 18: 59,185,687 (GRCm39) D1187V probably damaging Het
Adcy6 G C 15: 98,497,888 (GRCm39) I421M probably damaging Het
Afap1 C A 5: 36,131,835 (GRCm39) H387Q probably damaging Het
Atp8b1 C T 18: 64,678,335 (GRCm39) V854M probably damaging Het
Auts2 C T 5: 131,516,302 (GRCm39) probably benign Het
Cbll1 T C 12: 31,537,855 (GRCm39) D300G probably damaging Het
Cd200r4 A T 16: 44,653,412 (GRCm39) T61S possibly damaging Het
Chmp4c G T 3: 10,454,744 (GRCm39) V207L probably benign Het
Cntn5 T C 9: 9,976,321 (GRCm39) T413A possibly damaging Het
Cox7a2 T A 9: 79,665,863 (GRCm39) probably null Het
Cwc27 A G 13: 104,933,814 (GRCm39) L236P probably damaging Het
Diaph1 A G 18: 38,029,146 (GRCm39) probably null Het
Dst T A 1: 34,299,453 (GRCm39) probably benign Het
Ear1 T A 14: 44,056,583 (GRCm39) H95L probably damaging Het
Enpp1 T A 10: 24,517,732 (GRCm39) H898L probably benign Het
Entpd5 G A 12: 84,429,069 (GRCm39) R321* probably null Het
Ercc6l2 C A 13: 63,972,685 (GRCm39) N177K possibly damaging Het
Ergic1 T C 17: 26,860,680 (GRCm39) probably null Het
Erich6 A T 3: 58,534,019 (GRCm39) I336N probably benign Het
Fmnl2 A G 2: 52,995,549 (GRCm39) E424G probably damaging Het
Galnt3 A T 2: 65,914,550 (GRCm39) D622E probably damaging Het
Gjd4 T A 18: 9,280,569 (GRCm39) T170S probably damaging Het
Gm5611 G A 9: 16,941,903 (GRCm39) noncoding transcript Het
Gpc5 T A 14: 115,636,662 (GRCm39) N448K probably benign Het
Klra3 G C 6: 130,310,107 (GRCm39) R138G probably benign Het
Maco1 A G 4: 134,531,818 (GRCm39) V617A probably damaging Het
Man2b2 T C 5: 36,978,271 (GRCm39) T338A probably benign Het
Mbtps1 A T 8: 120,272,864 (GRCm39) S94T probably benign Het
Muc3a A T 5: 137,244,538 (GRCm39) S205T unknown Het
Nav2 C A 7: 49,195,682 (GRCm39) D1019E probably damaging Het
Neurl4 T A 11: 69,794,252 (GRCm39) L236* probably null Het
Or13c25 A G 4: 52,911,260 (GRCm39) V178A probably benign Het
Plcxd3 T C 15: 4,546,093 (GRCm39) probably benign Het
Pprc1 T C 19: 46,059,965 (GRCm39) probably benign Het
Prkaa2 T A 4: 104,932,647 (GRCm39) N67I probably damaging Het
Prom1 T A 5: 44,175,695 (GRCm39) Y508F probably benign Het
Prx A G 7: 27,216,683 (GRCm39) M534V probably damaging Het
Rps6kc1 C T 1: 190,603,965 (GRCm39) R219Q possibly damaging Het
Sbf2 T C 7: 109,977,250 (GRCm39) Y628C probably damaging Het
Slc1a2 A T 2: 102,607,855 (GRCm39) D501V probably benign Het
Spata31 A T 13: 65,069,196 (GRCm39) Q448L probably damaging Het
Stxbp5 T A 10: 9,713,836 (GRCm39) R234S probably damaging Het
Tifab A G 13: 56,324,101 (GRCm39) V114A probably benign Het
Tiprl A G 1: 165,055,975 (GRCm39) M49T probably benign Het
Tlr12 A G 4: 128,511,545 (GRCm39) L235P possibly damaging Het
Trim43b A T 9: 88,967,411 (GRCm39) C407* probably null Het
Txndc17 C A 11: 72,098,533 (GRCm39) F28L probably damaging Het
Vmn2r27 T C 6: 124,177,649 (GRCm39) R452G probably damaging Het
Vmn2r3 T A 3: 64,182,538 (GRCm39) D387V probably damaging Het
Vps13b T C 15: 35,875,712 (GRCm39) I2699T probably damaging Het
Zfp944 G T 17: 22,558,697 (GRCm39) Y183* probably null Het
Other mutations in Stk35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00850:Stk35 APN 2 129,643,912 (GRCm39) missense probably damaging 1.00
IGL02609:Stk35 APN 2 129,643,721 (GRCm39) missense probably damaging 1.00
fingernails UTSW 2 129,652,855 (GRCm39) missense probably damaging 1.00
R2256_Stk35_331 UTSW 2 129,652,427 (GRCm39) nonsense probably null
skinned UTSW 2 129,653,155 (GRCm39) intron probably benign
R0045:Stk35 UTSW 2 129,642,488 (GRCm39) nonsense probably null
R0306:Stk35 UTSW 2 129,643,683 (GRCm39) nonsense probably null
R0784:Stk35 UTSW 2 129,652,722 (GRCm39) nonsense probably null
R2256:Stk35 UTSW 2 129,652,427 (GRCm39) nonsense probably null
R2507:Stk35 UTSW 2 129,643,435 (GRCm39) missense probably damaging 0.97
R2508:Stk35 UTSW 2 129,643,435 (GRCm39) missense probably damaging 0.97
R3848:Stk35 UTSW 2 129,642,656 (GRCm39) missense probably benign 0.13
R3872:Stk35 UTSW 2 129,652,495 (GRCm39) missense possibly damaging 0.82
R4466:Stk35 UTSW 2 129,643,436 (GRCm39) missense probably damaging 0.99
R5144:Stk35 UTSW 2 129,652,855 (GRCm39) missense probably damaging 1.00
R6267:Stk35 UTSW 2 129,652,808 (GRCm39) nonsense probably null
R6296:Stk35 UTSW 2 129,652,808 (GRCm39) nonsense probably null
R6480:Stk35 UTSW 2 129,652,607 (GRCm39) missense possibly damaging 0.95
R6807:Stk35 UTSW 2 129,643,573 (GRCm39) missense probably damaging 0.97
R7203:Stk35 UTSW 2 129,643,513 (GRCm39) missense probably benign
R7476:Stk35 UTSW 2 129,652,645 (GRCm39) missense probably damaging 1.00
R8505:Stk35 UTSW 2 129,643,649 (GRCm39) missense probably damaging 0.99
R8998:Stk35 UTSW 2 129,652,509 (GRCm39) missense probably damaging 1.00
R8999:Stk35 UTSW 2 129,652,509 (GRCm39) missense probably damaging 1.00
R9224:Stk35 UTSW 2 129,652,491 (GRCm39) missense probably damaging 1.00
R9760:Stk35 UTSW 2 129,642,605 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGGTGAGGCGCTGCTAGAAAACC -3'
(R):5'- CCATGAACAAGCAAGCACAGTTGGG -3'

Sequencing Primer
(F):5'- AAGATGGAGTTGCATATCCCC -3'
(R):5'- CTGAAGAACTTGAAAGATTCAGCCTC -3'
Posted On 2015-03-23