Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00983:Zzz3'

27172

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zzz3

Ensembl Gene

ENSMUSG00000039068

Gene Name

zinc finger, ZZ domain containing 3

Synonyms

3110065C23Rik, 6430567E01Rik

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00983

Quality Score

Status

Chromosome

Chromosomal Location

152395473-152462826 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 152455810 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143693 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089982] [ENSMUST00000106100] [ENSMUST00000106101] [ENSMUST00000106103] [ENSMUST00000200570]

AlphaFold

Q6KAQ7

Predicted Effect

probably benign
Transcript: ENSMUST00000089982

SMART Domains

Protein: ENSMUSP00000087428
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	657	711	1.42e-9	SMART
low complexity region	776	787	N/A	INTRINSIC
low complexity region	799	814	N/A	INTRINSIC
ZnF_ZZ	823	871	6.46e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106100

SMART Domains

Protein: ENSMUSP00000101706
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106101

SMART Domains

Protein: ENSMUSP00000101707
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106103

SMART Domains

Protein: ENSMUSP00000101709
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	157	211	1.42e-9	SMART
low complexity region	276	287	N/A	INTRINSIC
low complexity region	299	314	N/A	INTRINSIC
ZnF_ZZ	323	371	6.46e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135044

Predicted Effect

probably benign
Transcript: ENSMUST00000200570

SMART Domains

Protein: ENSMUSP00000143693
Gene: ENSMUSG00000039068

Domain	Start	End	E-Value	Type
SANT	161	215	1.42e-9	SMART
low complexity region	280	291	N/A	INTRINSIC
low complexity region	303	318	N/A	INTRINSIC
ZnF_ZZ	327	375	6.46e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810021J22Rik	C	T	11: 58,880,612	Q307*	probably null	Het
Acss3	A	T	10: 106,966,964	C473*	probably null	Het
Adgrg1	T	A	8: 95,005,243	S178T	probably damaging	Het
Anxa7	C	A	14: 20,458,681	L386F	possibly damaging	Het
Calcrl	T	C	2: 84,370,454	E82G	probably benign	Het
Ccr9	C	T	9: 123,779,286	P11L	probably benign	Het
Cep164	C	A	9: 45,775,256	V887L	possibly damaging	Het
Dctn6	A	G	8: 34,092,593	L136P	probably damaging	Het
Dnase1	T	C	16: 4,039,553	V238A	possibly damaging	Het
Fat1	A	G	8: 45,033,390	Y3304C	probably damaging	Het
Fbxo31	A	T	8: 121,554,330	V359D	possibly damaging	Het
Gpr182	A	G	10: 127,750,788	I98T	possibly damaging	Het
Gspt1	C	T	16: 11,230,997		probably benign	Het
Itgam	C	A	7: 128,068,667	T70K	probably damaging	Het
Itpr2	A	G	6: 146,310,981		probably benign	Het
Kank3	T	A	17: 33,821,817	M458K	probably damaging	Het
Kcnd2	A	G	6: 21,714,154	K379E	possibly damaging	Het
Macf1	C	T	4: 123,382,122	V4206I	probably damaging	Het
Mdn1	T	C	4: 32,735,525	L3397S	probably damaging	Het
Msh3	A	T	13: 92,300,277	N508K	probably damaging	Het
Mttp	C	A	3: 138,115,129		probably benign	Het
Nme5	G	T	18: 34,567,128	Q155K	probably benign	Het
Olfr1341	A	T	4: 118,709,922	N172Y	probably damaging	Het
Olfr458	A	T	6: 42,460,095	I308N	probably benign	Het
Olfr548-ps1	T	A	7: 102,542,386	I150N	possibly damaging	Het
Pfkp	A	T	13: 6,581,567	W151R	probably damaging	Het
Pkd1l1	T	A	11: 8,844,585	T1859S	probably benign	Het
Pmvk	T	C	3: 89,467,583	W96R	probably damaging	Het
Prdx6b	T	A	2: 80,293,195	M116K	probably damaging	Het
Ptpro	A	C	6: 137,418,248	L876F	probably benign	Het
Sdcbp	G	T	4: 6,392,953	E197*	probably null	Het
Serpinb1c	A	T	13: 32,884,224	S188R	possibly damaging	Het
Sorcs1	A	T	19: 50,176,128	D988E	probably damaging	Het
Tmbim1	C	A	1: 74,295,263	G46V	probably damaging	Het
Ubl4b	C	T	3: 107,554,440	G168E	unknown	Het
Vmn2r91	T	C	17: 18,105,558	F146S	probably benign	Het
Zdhhc20	T	C	14: 57,839,156	N335D	possibly damaging	Het

Other mutations in Zzz3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00691:Zzz3	APN	3	152428514	missense	probably benign	0.16
IGL00707:Zzz3	APN	3	152449043	nonsense	probably null
IGL01586:Zzz3	APN	3	152455839	missense	possibly damaging	0.80
IGL01973:Zzz3	APN	3	152428370	missense	probably benign	0.00
IGL02002:Zzz3	APN	3	152451369	missense	probably damaging	0.98
IGL02009:Zzz3	APN	3	152428115	missense	possibly damaging	0.80
IGL02260:Zzz3	APN	3	152452083	missense	probably benign	0.04
IGL02336:Zzz3	APN	3	152428059	missense	possibly damaging	0.74
IGL02454:Zzz3	APN	3	152428574	missense	probably benign	0.03
IGL02519:Zzz3	APN	3	152427390	missense	probably damaging	1.00
R0067:Zzz3	UTSW	3	152428403	missense	possibly damaging	0.88
R0067:Zzz3	UTSW	3	152428403	missense	possibly damaging	0.88
R0314:Zzz3	UTSW	3	152427448	missense	probably benign	0.00
R0536:Zzz3	UTSW	3	152448828	missense	probably damaging	1.00
R1706:Zzz3	UTSW	3	152449098	missense	probably damaging	1.00
R2869:Zzz3	UTSW	3	152446844	synonymous	silent
R2870:Zzz3	UTSW	3	152446844	synonymous	silent
R2871:Zzz3	UTSW	3	152446844	synonymous	silent
R2872:Zzz3	UTSW	3	152446844	synonymous	silent
R3927:Zzz3	UTSW	3	152455862	missense	probably damaging	1.00
R4195:Zzz3	UTSW	3	152428465	missense	probably benign	0.02
R4768:Zzz3	UTSW	3	152448783	missense	probably damaging	1.00
R5248:Zzz3	UTSW	3	152427545	missense	probably damaging	0.99
R5566:Zzz3	UTSW	3	152455824	missense	probably damaging	1.00
R5752:Zzz3	UTSW	3	152452122	missense	possibly damaging	0.48
R5782:Zzz3	UTSW	3	152428100	missense	possibly damaging	0.69
R5884:Zzz3	UTSW	3	152450658	missense	probably damaging	1.00
R6008:Zzz3	UTSW	3	152428151	missense	probably benign	0.01
R6155:Zzz3	UTSW	3	152427682	missense	possibly damaging	0.57
R6557:Zzz3	UTSW	3	152428460	missense	probably damaging	1.00
R6865:Zzz3	UTSW	3	152428053	missense	probably benign	0.01
R7344:Zzz3	UTSW	3	152452099	missense	probably damaging	0.98
R7588:Zzz3	UTSW	3	152422768	missense	possibly damaging	0.85
R7636:Zzz3	UTSW	3	152427652	missense	probably benign
R7732:Zzz3	UTSW	3	152448842	missense	probably damaging	1.00
R8157:Zzz3	UTSW	3	152449648	missense	probably null	0.71
R8490:Zzz3	UTSW	3	152428653	nonsense	probably null
R8926:Zzz3	UTSW	3	152427892	missense	possibly damaging	0.76
R9143:Zzz3	UTSW	3	152458271	missense	probably benign	0.04
R9243:Zzz3	UTSW	3	152428283	missense	probably damaging	1.00
X0018:Zzz3	UTSW	3	152428733	missense	possibly damaging	0.88
Z1176:Zzz3	UTSW	3	152449097	missense	possibly damaging	0.94

Posted On

2013-04-17