Incidental Mutation 'R3777:Or4b13'
ID 271826
Institutional Source Beutler Lab
Gene Symbol Or4b13
Ensembl Gene ENSMUSG00000075063
Gene Name olfactory receptor family 4 subfamily B member 13
Synonyms K20, Olfr142, GA_x6K02T2Q125-51607674-51606757, MOR227-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R3777 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 90082413-90083330 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 90082969 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 121 (Y121C)
Ref Sequence ENSEMBL: ENSMUSP00000150216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099752] [ENSMUST00000213968]
AlphaFold Q60881
Predicted Effect probably damaging
Transcript: ENSMUST00000099752
AA Change: Y121C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097341
Gene: ENSMUSG00000075063
AA Change: Y121C

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 4.3e-53 PFAM
Pfam:7TM_GPCR_Srsx 33 300 3e-6 PFAM
Pfam:7tm_1 39 285 5.8e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213968
AA Change: Y121C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Dsg1b G A 18: 20,532,644 (GRCm39) V563I probably damaging Het
Elovl4 ACT A 9: 83,667,201 (GRCm39) probably null Het
Erp27 A T 6: 136,896,901 (GRCm39) N100K possibly damaging Het
Fam171b T A 2: 83,708,605 (GRCm39) I369K probably benign Het
Fmn1 A G 2: 113,195,467 (GRCm39) E389G unknown Het
Gm14569 T A X: 35,696,085 (GRCm39) M875L probably benign Het
Gm5819 A G 18: 8,694,429 (GRCm39) E118G probably damaging Het
Grip1 G A 10: 119,821,535 (GRCm39) probably null Het
Heatr1 C A 13: 12,428,229 (GRCm39) L789I possibly damaging Het
Hsd17b1 T C 11: 100,969,529 (GRCm39) S59P probably damaging Het
Ighv1-72 A T 12: 115,721,636 (GRCm39) S107T probably damaging Het
Inpp4b T A 8: 82,768,621 (GRCm39) V710D possibly damaging Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Larp4 T A 15: 99,888,238 (GRCm39) W92R probably damaging Het
Man2b2 T C 5: 36,972,871 (GRCm39) N548D probably benign Het
Mfsd4b2 A G 10: 39,797,527 (GRCm39) I276T possibly damaging Het
Mki67 A C 7: 135,297,859 (GRCm39) S2392A probably benign Het
Myl12a G T 17: 71,301,631 (GRCm39) H165Q possibly damaging Het
Myo18b T A 5: 112,905,462 (GRCm39) E2045D probably damaging Het
Mypn T C 10: 62,983,761 (GRCm39) T496A possibly damaging Het
Ncoa7 A G 10: 30,565,752 (GRCm39) Y632H probably damaging Het
Or13c3 A T 4: 52,855,636 (GRCm39) N292K probably damaging Het
Or2d4 A T 7: 106,543,519 (GRCm39) S230T probably benign Het
Or5p52 C A 7: 107,501,954 (GRCm39) A10E probably benign Het
Or8g33 A T 9: 39,337,901 (GRCm39) S155R possibly damaging Het
Pik3c2g A T 6: 139,599,385 (GRCm39) Y167F probably damaging Het
Pik3cg A C 12: 32,244,708 (GRCm39) C915W probably damaging Het
Ppfibp2 A G 7: 107,328,396 (GRCm39) T476A probably benign Het
Rapgef1 C T 2: 29,609,701 (GRCm39) H675Y possibly damaging Het
Rpn2 T A 2: 157,141,477 (GRCm39) V263D probably damaging Het
Rps13 A G 7: 115,933,160 (GRCm39) L16P probably damaging Het
Rsph14 C G 10: 74,793,419 (GRCm39) Q360H possibly damaging Het
Rsph14 T G 10: 74,793,420 (GRCm39) Q360P possibly damaging Het
Semp2l2b T C 10: 21,942,861 (GRCm39) E373G probably damaging Het
Smarcc2 G A 10: 128,318,812 (GRCm39) probably null Het
Sp8 G T 12: 118,812,750 (GRCm39) V202L possibly damaging Het
Spag9 G A 11: 93,989,852 (GRCm39) probably null Het
Svil A G 18: 5,090,855 (GRCm39) N915S probably damaging Het
Syt17 A G 7: 118,033,180 (GRCm39) L215P probably damaging Het
Tle6 G T 10: 81,431,987 (GRCm39) P86T probably benign Het
Tph2 T C 10: 114,915,910 (GRCm39) D421G probably benign Het
Trpm2 A C 10: 77,771,824 (GRCm39) L605R probably benign Het
Vat1l T C 8: 114,963,540 (GRCm39) probably null Het
Vdac3 T C 8: 23,070,525 (GRCm39) N128D probably benign Het
Vegfb G A 19: 6,964,767 (GRCm39) probably benign Het
Zfp808 T A 13: 62,319,717 (GRCm39) N315K probably damaging Het
Other mutations in Or4b13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Or4b13 APN 2 90,082,953 (GRCm39) missense probably damaging 1.00
IGL01623:Or4b13 APN 2 90,082,953 (GRCm39) missense probably damaging 1.00
IGL01810:Or4b13 APN 2 90,082,476 (GRCm39) nonsense probably null
IGL01918:Or4b13 APN 2 90,082,675 (GRCm39) missense probably damaging 1.00
IGL02619:Or4b13 APN 2 90,082,849 (GRCm39) missense probably damaging 0.97
IGL02732:Or4b13 APN 2 90,082,652 (GRCm39) missense probably damaging 1.00
IGL02738:Or4b13 APN 2 90,082,699 (GRCm39) missense possibly damaging 0.82
IGL02795:Or4b13 APN 2 90,082,906 (GRCm39) missense probably damaging 1.00
IGL02830:Or4b13 APN 2 90,083,125 (GRCm39) missense probably damaging 1.00
R0601:Or4b13 UTSW 2 90,083,278 (GRCm39) missense probably benign 0.05
R2004:Or4b13 UTSW 2 90,083,036 (GRCm39) missense probably benign 0.04
R2136:Or4b13 UTSW 2 90,082,597 (GRCm39) missense probably damaging 0.98
R2377:Or4b13 UTSW 2 90,083,255 (GRCm39) missense probably damaging 1.00
R3615:Or4b13 UTSW 2 90,082,753 (GRCm39) missense possibly damaging 0.94
R3616:Or4b13 UTSW 2 90,082,753 (GRCm39) missense possibly damaging 0.94
R4763:Or4b13 UTSW 2 90,082,807 (GRCm39) missense probably damaging 1.00
R4765:Or4b13 UTSW 2 90,082,807 (GRCm39) missense probably damaging 1.00
R5421:Or4b13 UTSW 2 90,083,089 (GRCm39) missense probably benign 0.01
R5426:Or4b13 UTSW 2 90,082,955 (GRCm39) nonsense probably null
R6063:Or4b13 UTSW 2 90,082,771 (GRCm39) missense probably benign 0.40
R6717:Or4b13 UTSW 2 90,082,868 (GRCm39) missense probably benign 0.00
R6931:Or4b13 UTSW 2 90,083,121 (GRCm39) nonsense probably null
R6936:Or4b13 UTSW 2 90,082,678 (GRCm39) missense probably benign 0.17
R7013:Or4b13 UTSW 2 90,082,441 (GRCm39) missense possibly damaging 0.87
R7091:Or4b13 UTSW 2 90,082,807 (GRCm39) missense probably damaging 1.00
R7247:Or4b13 UTSW 2 90,083,165 (GRCm39) missense probably damaging 1.00
R8169:Or4b13 UTSW 2 90,082,442 (GRCm39) nonsense probably null
R8345:Or4b13 UTSW 2 90,082,561 (GRCm39) missense possibly damaging 0.50
R9222:Or4b13 UTSW 2 90,082,820 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TGTTGGCCATCACAATAAACCC -3'
(R):5'- CCCTGGTGGAGATCTGTTACTC -3'

Sequencing Primer
(F):5'- CCTCCATAAAGGTGTCAGTGCAG -3'
(R):5'- GGAGATCTGTTACTCCTCTACAATTG -3'
Posted On 2015-03-25