Incidental Mutation 'R3777:Ncoa7'
ID 271849
Institutional Source Beutler Lab
Gene Symbol Ncoa7
Ensembl Gene ENSMUSG00000039697
Gene Name nuclear receptor coactivator 7
Synonyms 9030406N13Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3777 (G1)
Quality Score 191
Status Not validated
Chromosome 10
Chromosomal Location 30521578-30683401 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 30565752 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 632 (Y632H)
Ref Sequence ENSEMBL: ENSMUSP00000150021 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068567] [ENSMUST00000213836] [ENSMUST00000215740] [ENSMUST00000215926]
AlphaFold Q6DFV7
Predicted Effect probably damaging
Transcript: ENSMUST00000068567
AA Change: Y681H

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000066741
Gene: ENSMUSG00000039697
AA Change: Y681H

DomainStartEndE-ValueType
coiled coil region 1 32 N/A INTRINSIC
LysM 118 161 2.24e-7 SMART
low complexity region 165 176 N/A INTRINSIC
TLDc 781 943 2.86e-64 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000213836
AA Change: Y670H

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000215740
AA Change: Y681H

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000215926
AA Change: Y632H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably benign
Transcript: ENSMUST00000217398
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI

All alleles(108) : Gene trapped(108)

Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Dsg1b G A 18: 20,532,644 (GRCm39) V563I probably damaging Het
Elovl4 ACT A 9: 83,667,201 (GRCm39) probably null Het
Erp27 A T 6: 136,896,901 (GRCm39) N100K possibly damaging Het
Fam171b T A 2: 83,708,605 (GRCm39) I369K probably benign Het
Fmn1 A G 2: 113,195,467 (GRCm39) E389G unknown Het
Gm14569 T A X: 35,696,085 (GRCm39) M875L probably benign Het
Gm5819 A G 18: 8,694,429 (GRCm39) E118G probably damaging Het
Grip1 G A 10: 119,821,535 (GRCm39) probably null Het
Heatr1 C A 13: 12,428,229 (GRCm39) L789I possibly damaging Het
Hsd17b1 T C 11: 100,969,529 (GRCm39) S59P probably damaging Het
Ighv1-72 A T 12: 115,721,636 (GRCm39) S107T probably damaging Het
Inpp4b T A 8: 82,768,621 (GRCm39) V710D possibly damaging Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Larp4 T A 15: 99,888,238 (GRCm39) W92R probably damaging Het
Man2b2 T C 5: 36,972,871 (GRCm39) N548D probably benign Het
Mfsd4b2 A G 10: 39,797,527 (GRCm39) I276T possibly damaging Het
Mki67 A C 7: 135,297,859 (GRCm39) S2392A probably benign Het
Myl12a G T 17: 71,301,631 (GRCm39) H165Q possibly damaging Het
Myo18b T A 5: 112,905,462 (GRCm39) E2045D probably damaging Het
Mypn T C 10: 62,983,761 (GRCm39) T496A possibly damaging Het
Or13c3 A T 4: 52,855,636 (GRCm39) N292K probably damaging Het
Or2d4 A T 7: 106,543,519 (GRCm39) S230T probably benign Het
Or4b13 T C 2: 90,082,969 (GRCm39) Y121C probably damaging Het
Or5p52 C A 7: 107,501,954 (GRCm39) A10E probably benign Het
Or8g33 A T 9: 39,337,901 (GRCm39) S155R possibly damaging Het
Pik3c2g A T 6: 139,599,385 (GRCm39) Y167F probably damaging Het
Pik3cg A C 12: 32,244,708 (GRCm39) C915W probably damaging Het
Ppfibp2 A G 7: 107,328,396 (GRCm39) T476A probably benign Het
Rapgef1 C T 2: 29,609,701 (GRCm39) H675Y possibly damaging Het
Rpn2 T A 2: 157,141,477 (GRCm39) V263D probably damaging Het
Rps13 A G 7: 115,933,160 (GRCm39) L16P probably damaging Het
Rsph14 C G 10: 74,793,419 (GRCm39) Q360H possibly damaging Het
Rsph14 T G 10: 74,793,420 (GRCm39) Q360P possibly damaging Het
Semp2l2b T C 10: 21,942,861 (GRCm39) E373G probably damaging Het
Smarcc2 G A 10: 128,318,812 (GRCm39) probably null Het
Sp8 G T 12: 118,812,750 (GRCm39) V202L possibly damaging Het
Spag9 G A 11: 93,989,852 (GRCm39) probably null Het
Svil A G 18: 5,090,855 (GRCm39) N915S probably damaging Het
Syt17 A G 7: 118,033,180 (GRCm39) L215P probably damaging Het
Tle6 G T 10: 81,431,987 (GRCm39) P86T probably benign Het
Tph2 T C 10: 114,915,910 (GRCm39) D421G probably benign Het
Trpm2 A C 10: 77,771,824 (GRCm39) L605R probably benign Het
Vat1l T C 8: 114,963,540 (GRCm39) probably null Het
Vdac3 T C 8: 23,070,525 (GRCm39) N128D probably benign Het
Vegfb G A 19: 6,964,767 (GRCm39) probably benign Het
Zfp808 T A 13: 62,319,717 (GRCm39) N315K probably damaging Het
Other mutations in Ncoa7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01406:Ncoa7 APN 10 30,566,836 (GRCm39) missense probably damaging 1.00
IGL01716:Ncoa7 APN 10 30,538,330 (GRCm39) missense probably damaging 0.96
IGL02114:Ncoa7 APN 10 30,538,360 (GRCm39) missense probably damaging 1.00
IGL02170:Ncoa7 APN 10 30,565,849 (GRCm39) missense possibly damaging 0.94
IGL02436:Ncoa7 APN 10 30,570,143 (GRCm39) missense probably damaging 1.00
IGL02499:Ncoa7 APN 10 30,566,885 (GRCm39) missense probably benign 0.04
IGL02533:Ncoa7 APN 10 30,598,781 (GRCm39) missense probably damaging 1.00
IGL02533:Ncoa7 APN 10 30,566,895 (GRCm39) missense possibly damaging 0.87
IGL02590:Ncoa7 APN 10 30,570,159 (GRCm39) missense probably damaging 1.00
IGL02657:Ncoa7 APN 10 30,528,972 (GRCm39) missense probably damaging 1.00
IGL03065:Ncoa7 APN 10 30,523,993 (GRCm39) missense probably damaging 1.00
IGL03088:Ncoa7 APN 10 30,574,121 (GRCm39) splice site probably null
IGL03090:Ncoa7 APN 10 30,538,396 (GRCm39) missense probably damaging 0.96
IGL03196:Ncoa7 APN 10 30,523,510 (GRCm39) utr 3 prime probably benign
D6062:Ncoa7 UTSW 10 30,598,651 (GRCm39) missense probably damaging 1.00
R0058:Ncoa7 UTSW 10 30,523,537 (GRCm39) missense probably damaging 1.00
R0058:Ncoa7 UTSW 10 30,523,537 (GRCm39) missense probably damaging 1.00
R0578:Ncoa7 UTSW 10 30,577,913 (GRCm39) critical splice donor site probably null
R0729:Ncoa7 UTSW 10 30,567,575 (GRCm39) missense probably benign 0.00
R1538:Ncoa7 UTSW 10 30,570,207 (GRCm39) missense probably damaging 0.99
R1539:Ncoa7 UTSW 10 30,647,725 (GRCm39) missense probably damaging 1.00
R1574:Ncoa7 UTSW 10 30,570,097 (GRCm39) missense probably damaging 1.00
R1574:Ncoa7 UTSW 10 30,570,097 (GRCm39) missense probably damaging 1.00
R1624:Ncoa7 UTSW 10 30,580,655 (GRCm39) missense possibly damaging 0.87
R1639:Ncoa7 UTSW 10 30,577,988 (GRCm39) missense probably damaging 1.00
R1655:Ncoa7 UTSW 10 30,574,241 (GRCm39) critical splice acceptor site probably null
R1876:Ncoa7 UTSW 10 30,574,122 (GRCm39) intron probably benign
R1885:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1886:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1887:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1909:Ncoa7 UTSW 10 30,565,796 (GRCm39) missense probably damaging 1.00
R1938:Ncoa7 UTSW 10 30,574,166 (GRCm39) missense probably benign 0.02
R1965:Ncoa7 UTSW 10 30,530,426 (GRCm39) nonsense probably null
R1978:Ncoa7 UTSW 10 30,567,295 (GRCm39) missense probably benign
R2303:Ncoa7 UTSW 10 30,530,431 (GRCm39) missense probably damaging 1.00
R3778:Ncoa7 UTSW 10 30,565,752 (GRCm39) missense probably damaging 1.00
R4026:Ncoa7 UTSW 10 30,598,720 (GRCm39) missense probably benign 0.02
R4230:Ncoa7 UTSW 10 30,574,253 (GRCm39) splice site probably null
R4667:Ncoa7 UTSW 10 30,566,786 (GRCm39) missense probably damaging 1.00
R4786:Ncoa7 UTSW 10 30,531,638 (GRCm39) missense probably benign 0.28
R4809:Ncoa7 UTSW 10 30,647,758 (GRCm39) missense possibly damaging 0.92
R4820:Ncoa7 UTSW 10 30,524,472 (GRCm39) missense probably damaging 1.00
R4839:Ncoa7 UTSW 10 30,598,655 (GRCm39) missense possibly damaging 0.93
R4861:Ncoa7 UTSW 10 30,580,608 (GRCm39) missense probably benign
R4861:Ncoa7 UTSW 10 30,580,608 (GRCm39) missense probably benign
R5271:Ncoa7 UTSW 10 30,598,725 (GRCm39) missense probably benign 0.02
R5384:Ncoa7 UTSW 10 30,598,813 (GRCm39) missense probably benign 0.00
R5418:Ncoa7 UTSW 10 30,524,035 (GRCm39) missense probably damaging 1.00
R5964:Ncoa7 UTSW 10 30,580,632 (GRCm39) missense probably damaging 1.00
R6257:Ncoa7 UTSW 10 30,570,173 (GRCm39) missense probably damaging 1.00
R6683:Ncoa7 UTSW 10 30,647,717 (GRCm39) missense probably damaging 0.99
R6813:Ncoa7 UTSW 10 30,572,188 (GRCm39) missense probably damaging 1.00
R6910:Ncoa7 UTSW 10 30,570,117 (GRCm39) missense possibly damaging 0.89
R7123:Ncoa7 UTSW 10 30,530,435 (GRCm39) missense probably benign 0.28
R7327:Ncoa7 UTSW 10 30,565,796 (GRCm39) missense probably damaging 1.00
R7412:Ncoa7 UTSW 10 30,598,847 (GRCm39) missense possibly damaging 0.94
R7638:Ncoa7 UTSW 10 30,598,794 (GRCm39) missense probably benign 0.35
R7653:Ncoa7 UTSW 10 30,570,239 (GRCm39) missense probably damaging 1.00
R7848:Ncoa7 UTSW 10 30,524,414 (GRCm39) missense possibly damaging 0.82
R7861:Ncoa7 UTSW 10 30,567,056 (GRCm39) missense probably benign 0.38
R8125:Ncoa7 UTSW 10 30,570,087 (GRCm39) missense possibly damaging 0.80
R8198:Ncoa7 UTSW 10 30,580,664 (GRCm39) missense probably benign 0.00
R8240:Ncoa7 UTSW 10 30,567,725 (GRCm39) missense probably benign 0.45
R8353:Ncoa7 UTSW 10 30,570,155 (GRCm39) missense probably damaging 1.00
R8509:Ncoa7 UTSW 10 30,572,048 (GRCm39) missense probably benign 0.00
R8861:Ncoa7 UTSW 10 30,567,364 (GRCm39) missense probably benign 0.02
R9040:Ncoa7 UTSW 10 30,530,389 (GRCm39) missense probably benign 0.00
R9136:Ncoa7 UTSW 10 30,567,628 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTGCAGTTGTGTCAAAATGACC -3'
(R):5'- GAACCTTTTAACTGTCACTGGTG -3'

Sequencing Primer
(F):5'- AGTATGCACCCTTCAAGAAGC -3'
(R):5'- AACTGTCACTGGTGTTAACAGG -3'
Posted On 2015-03-25