Incidental Mutation 'R3778:Wnt6'
ID 271876
Institutional Source Beutler Lab
Gene Symbol Wnt6
Ensembl Gene ENSMUSG00000033227
Gene Name wingless-type MMTV integration site family, member 6
Synonyms Wnt-6
MMRRC Submission 040750-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3778 (G1)
Quality Score 186
Status Not validated
Chromosome 1
Chromosomal Location 74811051-74824481 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 74821941 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 174 (D174A)
Ref Sequence ENSEMBL: ENSMUSP00000006716 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006716]
AlphaFold P22727
Predicted Effect possibly damaging
Transcript: ENSMUST00000006716
AA Change: D174A

PolyPhen 2 Score 0.867 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000006716
Gene: ENSMUSG00000033227
AA Change: D174A

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
WNT1 42 364 6.06e-197 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189544
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 A T 15: 64,618,846 (GRCm39) L769H probably damaging Het
Aldh1a7 A T 19: 20,696,675 (GRCm39) M106K possibly damaging Het
Ankfn1 G T 11: 89,332,220 (GRCm39) P442Q probably damaging Het
Aox1 A C 1: 58,092,862 (GRCm39) D158A possibly damaging Het
Apc A G 18: 34,446,134 (GRCm39) N976S probably damaging Het
Cfap54 C T 10: 92,740,206 (GRCm39) probably benign Het
Cldn1 C T 16: 26,190,216 (GRCm39) C54Y probably damaging Het
Col22a1 A T 15: 71,845,541 (GRCm39) I407N probably damaging Het
Cyp2e1 T C 7: 140,343,822 (GRCm39) V20A possibly damaging Het
Erp27 A T 6: 136,896,901 (GRCm39) N100K possibly damaging Het
Fbn1 C T 2: 125,159,006 (GRCm39) C2253Y probably damaging Het
Fhip1b T A 7: 105,037,435 (GRCm39) T383S probably damaging Het
Flnb G A 14: 7,915,353 (GRCm38) V1495I probably benign Het
Fscn3 A C 6: 28,430,031 (GRCm39) K67T possibly damaging Het
Gls A G 1: 52,208,071 (GRCm39) V571A probably benign Het
Gm14569 T A X: 35,696,085 (GRCm39) M875L probably benign Het
Gm4871 A G 5: 144,966,893 (GRCm39) S197P probably damaging Het
Gm7104 A T 12: 88,252,441 (GRCm39) noncoding transcript Het
Gp9 A T 6: 87,755,987 (GRCm39) M1L probably benign Het
Greb1l T A 18: 10,469,444 (GRCm39) L153H possibly damaging Het
H1f8 T C 6: 115,926,708 (GRCm39) probably null Het
Hadha A T 5: 30,325,127 (GRCm39) C688S probably damaging Het
Hif1an A G 19: 44,557,847 (GRCm39) D243G probably damaging Het
Hmcn1 A T 1: 150,678,575 (GRCm39) D515E possibly damaging Het
Hsfy2 A T 1: 56,675,847 (GRCm39) V230E possibly damaging Het
Ighv1-72 A T 12: 115,721,636 (GRCm39) S107T probably damaging Het
Inpp4b T A 8: 82,768,621 (GRCm39) V710D possibly damaging Het
Itpr3 A G 17: 27,314,446 (GRCm39) D632G possibly damaging Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Lrig2 A G 3: 104,365,277 (GRCm39) I625T probably benign Het
Lrp2 A T 2: 69,339,548 (GRCm39) M1121K probably benign Het
Man2b2 T C 5: 36,972,871 (GRCm39) N548D probably benign Het
Mei1 T C 15: 81,966,209 (GRCm39) L277P probably damaging Het
Mki67 A C 7: 135,297,859 (GRCm39) S2392A probably benign Het
Mycbp2 T A 14: 103,434,721 (GRCm39) I2241F probably damaging Het
Nalcn G A 14: 123,702,128 (GRCm39) T461M probably damaging Het
Ncoa6 A G 2: 155,263,115 (GRCm39) S440P probably damaging Het
Ncoa7 A G 10: 30,565,752 (GRCm39) Y632H probably damaging Het
Notch2 T C 3: 98,053,939 (GRCm39) S2201P probably damaging Het
Or10c1 T C 17: 37,522,649 (GRCm39) T32A probably benign Het
Or5p52 C A 7: 107,501,954 (GRCm39) A10E probably benign Het
Pard6g A T 18: 80,123,038 (GRCm39) probably null Het
Pask T A 1: 93,255,189 (GRCm39) I294F probably damaging Het
Pax9 A G 12: 56,743,533 (GRCm39) Y60C probably damaging Het
Pcdh15 G A 10: 73,782,983 (GRCm39) probably null Het
Pik3c2g A T 6: 139,599,385 (GRCm39) Y167F probably damaging Het
Ppfibp2 A G 7: 107,328,396 (GRCm39) T476A probably benign Het
Ppm1e T C 11: 87,139,754 (GRCm39) probably null Het
Rsph14 T G 10: 74,793,420 (GRCm39) Q360P possibly damaging Het
Rsph14 C G 10: 74,793,419 (GRCm39) Q360H possibly damaging Het
Sec24c A G 14: 20,733,375 (GRCm39) Q234R possibly damaging Het
Shcbp1 A T 8: 4,786,295 (GRCm39) N602K probably benign Het
Sirt5 A G 13: 43,536,583 (GRCm39) probably null Het
Slc66a1 T C 4: 139,026,293 (GRCm39) probably null Het
Sp8 G T 12: 118,812,750 (GRCm39) V202L possibly damaging Het
Tle6 G T 10: 81,431,987 (GRCm39) P86T probably benign Het
Tmem235 A T 11: 117,753,126 (GRCm39) H83L probably benign Het
Trappc10 A G 10: 78,036,636 (GRCm39) V861A possibly damaging Het
Trpm2 A C 10: 77,771,824 (GRCm39) L605R probably benign Het
Vat1l T C 8: 114,963,540 (GRCm39) probably null Het
Wwox T C 8: 115,601,347 (GRCm39) C355R probably benign Het
Zfp229 A T 17: 21,964,183 (GRCm39) T138S probably benign Het
Other mutations in Wnt6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03055:Wnt6 UTSW 1 74,822,013 (GRCm39) missense probably damaging 1.00
R1467:Wnt6 UTSW 1 74,821,434 (GRCm39) missense probably damaging 1.00
R1467:Wnt6 UTSW 1 74,821,434 (GRCm39) missense probably damaging 1.00
R4865:Wnt6 UTSW 1 74,821,788 (GRCm39) missense probably damaging 0.99
R4927:Wnt6 UTSW 1 74,823,296 (GRCm39) critical splice acceptor site probably null
R4927:Wnt6 UTSW 1 74,823,295 (GRCm39) splice site probably null
R5133:Wnt6 UTSW 1 74,823,755 (GRCm39) missense probably damaging 1.00
R7714:Wnt6 UTSW 1 74,823,422 (GRCm39) missense probably damaging 0.99
R8706:Wnt6 UTSW 1 74,821,947 (GRCm39) missense possibly damaging 0.46
RF024:Wnt6 UTSW 1 74,821,980 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTTTGCAATCACCGCAGC -3'
(R):5'- CGCTGACACACTCTGACATTC -3'

Sequencing Primer
(F):5'- AATCACCGCAGCTGGTG -3'
(R):5'- ACTTGTGCCCACGCTAC -3'
Posted On 2015-03-25