Incidental Mutation 'R3779:Mtrex'
ID 271977
Institutional Source Beutler Lab
Gene Symbol Mtrex
Ensembl Gene ENSMUSG00000016018
Gene Name Mtr4 exosome RNA helicase
Synonyms Skiv2l2, 2610528A15Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R3779 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 113004306-113063914 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 113039926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000022281 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022281]
AlphaFold Q9CZU3
Predicted Effect probably benign
Transcript: ENSMUST00000022281
SMART Domains Protein: ENSMUSP00000022281
Gene: ENSMUSG00000016018

DomainStartEndE-ValueType
low complexity region 20 37 N/A INTRINSIC
DEXDc 134 317 6.42e-34 SMART
HELICc 437 526 3.14e-19 SMART
Pfam:rRNA_proc-arch 580 839 1.7e-91 PFAM
DSHCT 863 1040 1.69e-96 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 98% (47/48)
Allele List at MGI

All alleles(16) : Targeted(2) Gene trapped(14)

Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik A G 16: 88,424,273 (GRCm39) C73R probably damaging Het
Acot10 A G 15: 20,665,628 (GRCm39) V371A probably damaging Het
Ambn C A 5: 88,613,201 (GRCm39) probably benign Het
Ankrd34a T C 3: 96,506,247 (GRCm39) F484L possibly damaging Het
Bcl11a A G 11: 24,114,568 (GRCm39) K637R probably damaging Het
Cenpe T C 3: 134,962,337 (GRCm39) S1968P possibly damaging Het
Cfap61 T C 2: 145,792,714 (GRCm39) I52T probably damaging Het
Cit A T 5: 115,997,400 (GRCm39) M128L probably benign Het
Cnga1 G T 5: 72,762,126 (GRCm39) L463I probably damaging Het
Dnah11 C T 12: 118,094,448 (GRCm39) probably benign Het
Elovl4 ACT A 9: 83,667,201 (GRCm39) probably null Het
Ep400 A G 5: 110,839,515 (GRCm39) I1853T unknown Het
Flg2 C T 3: 93,109,730 (GRCm39) S586L unknown Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably benign Het
Gm21886 G T 18: 80,132,649 (GRCm39) Q170K possibly damaging Het
Gm5819 A G 18: 8,694,429 (GRCm39) E118G probably damaging Het
Gm9376 T C 14: 118,504,727 (GRCm39) V53A probably benign Het
H2-T3 T C 17: 36,500,574 (GRCm39) T90A probably damaging Het
Hif1an A G 19: 44,557,847 (GRCm39) D243G probably damaging Het
Hmgcs2 C T 3: 98,206,428 (GRCm39) probably benign Het
Ighv1-72 A T 12: 115,721,636 (GRCm39) S107T probably damaging Het
Jak1 G A 4: 101,013,687 (GRCm39) H1014Y probably benign Het
Klrb1c T C 6: 128,757,306 (GRCm39) D253G probably damaging Het
Lpin1 G A 12: 16,614,569 (GRCm39) T404M probably damaging Het
Map3k9 A T 12: 81,790,565 (GRCm39) probably benign Het
Myl12a G T 17: 71,301,631 (GRCm39) H165Q possibly damaging Het
Or6c38 A G 10: 128,929,165 (GRCm39) F226S possibly damaging Het
Pdgfrb T A 18: 61,205,738 (GRCm39) S575T probably damaging Het
Phldb2 T C 16: 45,569,118 (GRCm39) Y1247C probably damaging Het
Pinlyp T A 7: 24,241,260 (GRCm39) T181S probably benign Het
Pkn2 A G 3: 142,499,741 (GRCm39) V928A possibly damaging Het
Skint5 C T 4: 113,636,237 (GRCm39) probably benign Het
Slc24a1 A G 9: 64,855,579 (GRCm39) Y443H unknown Het
Sp8 G T 12: 118,812,750 (GRCm39) V202L possibly damaging Het
Svil A G 18: 5,090,855 (GRCm39) N915S probably damaging Het
Syncrip A C 9: 88,358,992 (GRCm39) D172E probably damaging Het
Tex26 T C 5: 149,369,316 (GRCm39) I48T probably damaging Het
Trpm6 A C 19: 18,853,403 (GRCm39) I1808L possibly damaging Het
Uba2 T C 7: 33,854,071 (GRCm39) probably null Het
Vwa8 T A 14: 79,339,762 (GRCm39) probably benign Het
Wfs1 C A 5: 37,125,968 (GRCm39) V308L probably benign Het
Wrn T A 8: 33,731,048 (GRCm39) R1095W probably damaging Het
Zfp808 T A 13: 62,319,717 (GRCm39) N315K probably damaging Het
Other mutations in Mtrex
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01077:Mtrex APN 13 113,051,023 (GRCm39) missense probably damaging 1.00
IGL01772:Mtrex APN 13 113,027,859 (GRCm39) missense probably benign 0.10
IGL01843:Mtrex APN 13 113,055,095 (GRCm39) splice site probably benign
IGL01972:Mtrex APN 13 113,017,595 (GRCm39) missense probably damaging 1.00
IGL02451:Mtrex APN 13 113,027,881 (GRCm39) missense probably damaging 1.00
IGL02716:Mtrex APN 13 113,019,680 (GRCm39) missense probably benign 0.13
IGL03234:Mtrex APN 13 113,017,509 (GRCm39) splice site probably benign
K3955:Mtrex UTSW 13 113,047,513 (GRCm39) nonsense probably null
P0038:Mtrex UTSW 13 113,047,513 (GRCm39) nonsense probably null
R0067:Mtrex UTSW 13 113,023,396 (GRCm39) missense probably benign 0.34
R0067:Mtrex UTSW 13 113,023,396 (GRCm39) missense probably benign 0.34
R0086:Mtrex UTSW 13 113,063,862 (GRCm39) missense probably benign 0.00
R0687:Mtrex UTSW 13 113,050,895 (GRCm39) missense probably damaging 1.00
R1216:Mtrex UTSW 13 113,050,876 (GRCm39) splice site probably benign
R1218:Mtrex UTSW 13 113,054,156 (GRCm39) missense probably damaging 1.00
R1312:Mtrex UTSW 13 113,019,785 (GRCm39) nonsense probably null
R1827:Mtrex UTSW 13 113,049,633 (GRCm39) critical splice donor site probably null
R1852:Mtrex UTSW 13 113,009,461 (GRCm39) missense probably benign 0.00
R1889:Mtrex UTSW 13 113,024,024 (GRCm39) missense probably benign 0.00
R2205:Mtrex UTSW 13 113,035,424 (GRCm39) missense probably benign 0.06
R2256:Mtrex UTSW 13 113,013,046 (GRCm39) missense probably damaging 0.98
R2394:Mtrex UTSW 13 113,019,702 (GRCm39) missense probably benign 0.02
R3717:Mtrex UTSW 13 113,032,129 (GRCm39) missense probably damaging 1.00
R4613:Mtrex UTSW 13 113,058,273 (GRCm39) nonsense probably null
R4939:Mtrex UTSW 13 113,046,426 (GRCm39) missense possibly damaging 0.91
R5452:Mtrex UTSW 13 113,049,715 (GRCm39) missense probably null 0.96
R5591:Mtrex UTSW 13 113,063,890 (GRCm39) start codon destroyed probably null 0.88
R5688:Mtrex UTSW 13 113,009,590 (GRCm39) nonsense probably null
R5761:Mtrex UTSW 13 113,054,196 (GRCm39) missense probably damaging 0.96
R5789:Mtrex UTSW 13 113,027,819 (GRCm39) missense probably benign 0.01
R5851:Mtrex UTSW 13 113,045,486 (GRCm39) missense probably damaging 1.00
R6038:Mtrex UTSW 13 113,027,824 (GRCm39) missense probably benign 0.00
R6038:Mtrex UTSW 13 113,027,824 (GRCm39) missense probably benign 0.00
R6348:Mtrex UTSW 13 113,047,451 (GRCm39) missense possibly damaging 0.88
R7276:Mtrex UTSW 13 113,050,973 (GRCm39) missense probably benign 0.00
R7397:Mtrex UTSW 13 113,058,220 (GRCm39) missense probably benign
R7792:Mtrex UTSW 13 113,009,443 (GRCm39) missense probably benign 0.02
R7863:Mtrex UTSW 13 113,045,435 (GRCm39) missense probably benign 0.00
R7948:Mtrex UTSW 13 113,058,296 (GRCm39) missense probably benign 0.02
R8035:Mtrex UTSW 13 113,035,336 (GRCm39) missense probably benign 0.09
R8124:Mtrex UTSW 13 113,063,871 (GRCm39) missense probably benign 0.01
R8152:Mtrex UTSW 13 113,009,517 (GRCm39) nonsense probably null
R8189:Mtrex UTSW 13 113,028,515 (GRCm39) missense possibly damaging 0.54
R8880:Mtrex UTSW 13 113,051,034 (GRCm39) missense probably benign 0.04
R9228:Mtrex UTSW 13 113,050,888 (GRCm39) critical splice donor site probably null
R9281:Mtrex UTSW 13 113,046,443 (GRCm39) nonsense probably null
R9679:Mtrex UTSW 13 113,032,055 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACAACCTGCCGATGGGGA -3'
(R):5'- AGCCAGACCACATTGTGTTTCAA -3'

Sequencing Primer
(F):5'- TGCCGATGGGGACTGGG -3'
(R):5'- AGGTTGGATTTTGCATTTATTCTGG -3'
Posted On 2015-03-25