Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00906:Srarp'

27214

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Srarp

Ensembl Gene

ENSMUSG00000070637

Gene Name

steroid receptor associated and regulated protein

Synonyms

Gm694, LOC277744

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

IGL00906

Quality Score

Status

Chromosome

Chromosomal Location

141159983-141163416 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 141160584 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 83 (T83M)

Ref Sequence

ENSEMBL: ENSMUSP00000092122 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094544]

AlphaFold

Q3ULG3

Predicted Effect

probably benign
Transcript: ENSMUST00000094544
AA Change: T83M

PolyPhen 2 Score 0.385 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000092122
Gene: ENSMUSG00000070637
AA Change: T83M

Domain	Start	End	E-Value	Type
Pfam:DUF4654	27	163	3.1e-61	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	A	G	5: 125,580,338 (GRCm39)	E221G	probably benign	Het
Alb	A	G	5: 90,619,932 (GRCm39)	N453S	probably benign	Het
Bckdha	C	T	7: 25,332,767 (GRCm39)	V183M	probably benign	Het
Brpf3	A	G	17: 29,055,674 (GRCm39)		probably benign	Het
Ccdc163	T	C	4: 116,567,487 (GRCm39)		probably null	Het
Ccdc178	A	T	18: 22,268,225 (GRCm39)	C87*	probably null	Het
Cfhr4	A	T	1: 139,659,312 (GRCm39)	V739E	probably damaging	Het
Clca4a	A	G	3: 144,660,700 (GRCm39)	V708A	probably damaging	Het
Cyfip2	A	G	11: 46,091,512 (GRCm39)	V1136A	possibly damaging	Het
Dnah11	A	C	12: 117,874,937 (GRCm39)	L3976R	probably damaging	Het
Erich1	A	G	8: 14,083,770 (GRCm39)		probably benign	Het
Fam228a	A	T	12: 4,782,773 (GRCm39)	Y107N	possibly damaging	Het
Iars2	A	T	1: 185,028,600 (GRCm39)		probably benign	Het
Ifi204	A	G	1: 173,587,197 (GRCm39)		probably benign	Het
Ifih1	A	T	2: 62,476,168 (GRCm39)	I36N	probably benign	Het
Jak1	C	T	4: 101,011,826 (GRCm39)	G1092D	probably damaging	Het
Kir3dl2	G	A	X: 135,357,097 (GRCm39)	P122S	probably damaging	Het
Nacc2	T	C	2: 25,951,678 (GRCm39)	T386A	probably damaging	Het
Nrf1	C	T	6: 30,098,477 (GRCm39)	T135M	probably damaging	Het
Or4k15	A	G	14: 50,364,214 (GRCm39)	Y60C	probably damaging	Het
Or51i2	G	A	7: 103,689,051 (GRCm39)	G16D	probably damaging	Het
Pcca	A	C	14: 122,927,545 (GRCm39)	D436A	probably benign	Het
Pcdhb11	A	T	18: 37,555,174 (GRCm39)	Q168L	possibly damaging	Het
Pdgfra	A	G	5: 75,340,834 (GRCm39)	I598V	probably benign	Het
Pla2g6	C	T	15: 79,171,947 (GRCm39)	V637I	probably damaging	Het
Plac1	A	C	X: 52,159,593 (GRCm39)	V39G	probably damaging	Het
Pparg	A	G	6: 115,416,822 (GRCm39)	E5G	probably damaging	Het
Ppp1r9a	A	G	6: 5,157,023 (GRCm39)	D967G	possibly damaging	Het
Rel	T	C	11: 23,694,266 (GRCm39)	T322A	probably benign	Het
Sgk3	A	G	1: 9,947,470 (GRCm39)	T137A	probably benign	Het
Sgpp2	A	G	1: 78,367,184 (GRCm39)	R106G	probably benign	Het
Slc27a5	T	A	7: 12,724,984 (GRCm39)	M459L	probably benign	Het
Snx21	T	C	2: 164,628,140 (GRCm39)	L52P	probably damaging	Het
Sstr2	A	G	11: 113,515,821 (GRCm39)	R247G	probably benign	Het
Tnpo3	G	A	6: 29,589,047 (GRCm39)	S101L	probably damaging	Het
Zan	A	G	5: 137,387,622 (GRCm39)	I4863T	unknown	Het

Other mutations in Srarp

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0323:Srarp	UTSW	4	141,160,690 (GRCm39)	nonsense	probably null
R0410:Srarp	UTSW	4	141,160,459 (GRCm39)	missense	possibly damaging	0.71
R1074:Srarp	UTSW	4	141,160,707 (GRCm39)	missense	probably damaging	0.99
R5443:Srarp	UTSW	4	141,163,388 (GRCm39)	start gained	probably null
R7270:Srarp	UTSW	4	141,160,389 (GRCm39)	missense	possibly damaging	0.51
R8341:Srarp	UTSW	4	141,160,707 (GRCm39)	missense	possibly damaging	0.92
R9011:Srarp	UTSW	4	141,160,344 (GRCm39)	missense	possibly damaging	0.85

Posted On

2013-04-17