Mutagenetix > Incidental Mutation

Incidental Mutation 'R3789:Vmn2r23'

272434

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

041604-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R3789 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

123679780-123719198 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 123718348 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 567 (N567I)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158091

Predicted Effect

probably damaging
Transcript: ENSMUST00000172391
AA Change: N567I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: N567I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 93.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,460,668 (GRCm39)	I4226N	probably damaging	Het
Abhd16a	A	G	17: 35,320,563 (GRCm39)	N411S	probably damaging	Het
Acvrl1	C	T	15: 101,035,350 (GRCm39)	T292M	probably damaging	Het
Adamts8	T	C	9: 30,870,588 (GRCm39)	S688P	probably damaging	Het
Adprs	A	T	4: 126,210,544 (GRCm39)	I312N	probably damaging	Het
Bclaf3	A	G	X: 158,349,492 (GRCm39)	H619R	probably benign	Het
Clca4a	C	A	3: 144,680,717 (GRCm39)	G20V	probably damaging	Het
Col12a1	C	A	9: 79,547,005 (GRCm39)	V2276L	possibly damaging	Het
Cstdc2	C	A	2: 148,689,878 (GRCm39)	E92*	probably null	Het
Drosha	T	A	15: 12,912,623 (GRCm39)	Y1080*	probably null	Het
Dysf	G	A	6: 84,163,491 (GRCm39)		probably null	Het
Ebf2	T	A	14: 67,476,942 (GRCm39)		probably null	Het
Emc8	T	C	8: 121,384,869 (GRCm39)	T195A	probably benign	Het
Frs3	G	A	17: 48,010,621 (GRCm39)		probably null	Het
Fsip2	T	C	2: 82,813,058 (GRCm39)	S640P	probably damaging	Het
Hdhd2	G	A	18: 77,042,883 (GRCm39)		probably null	Het
Hivep3	T	C	4: 119,955,613 (GRCm39)	S1310P	probably damaging	Het
Hltf	C	T	3: 20,123,211 (GRCm39)	P200S	probably damaging	Het
Lnpk	A	T	2: 74,352,607 (GRCm39)	S358R	probably benign	Het
Lrp1	T	C	10: 127,407,838 (GRCm39)	D1817G	possibly damaging	Het
Lrpprc	T	C	17: 85,078,956 (GRCm39)	I253V	probably benign	Het
Map2	A	G	1: 66,456,022 (GRCm39)	T1512A	probably damaging	Het
Mcm9	G	A	10: 53,492,113 (GRCm39)	R403W	probably damaging	Het
Mms22l	A	G	4: 24,517,115 (GRCm39)	D222G	possibly damaging	Het
Mug1	G	A	6: 121,861,587 (GRCm39)	V1350I	probably benign	Het
Or56b2j	T	A	7: 104,353,156 (GRCm39)	D127E	probably damaging	Het
Pclo	A	G	5: 14,730,464 (GRCm39)		probably benign	Het
Plekha7	A	C	7: 115,774,969 (GRCm39)	I175R	probably damaging	Het
Plxnb1	T	A	9: 108,938,355 (GRCm39)	V1303D	possibly damaging	Het
Pou2f1	G	C	1: 165,722,538 (GRCm39)	P349R	probably damaging	Het
Prmt8	A	T	6: 127,688,110 (GRCm39)	I236N	probably damaging	Het
Rexo2	A	G	9: 48,384,362 (GRCm39)	I139T	probably damaging	Het
Rsbn1l	A	C	5: 21,101,106 (GRCm39)	S811R	probably benign	Het
Sec24b	T	C	3: 129,814,276 (GRCm39)	D345G	probably benign	Het
Serpina1b	A	G	12: 103,695,531 (GRCm39)	S337P	probably damaging	Het
Sinhcaf	A	G	6: 148,827,617 (GRCm39)	S134P	possibly damaging	Het
Snx33	T	C	9: 56,825,844 (GRCm39)	E539G	probably benign	Het
Sorcs3	A	G	19: 48,387,150 (GRCm39)	T212A	possibly damaging	Het
Spa17	T	G	9: 37,523,141 (GRCm39)	K49Q	possibly damaging	Het
St3gal6	C	T	16: 58,305,136 (GRCm39)	E109K	probably benign	Het
Stat4	A	G	1: 52,050,955 (GRCm39)	N5D	probably benign	Het
Tmem232	C	T	17: 65,689,520 (GRCm39)	D532N	probably benign	Het
Tmem232	C	A	17: 65,689,628 (GRCm39)	D496Y	possibly damaging	Het
Tmem81	A	G	1: 132,435,809 (GRCm39)	N205S	probably benign	Het
Tomm20l	C	T	12: 71,158,516 (GRCm39)	A58V	possibly damaging	Het
Ttn	A	G	2: 76,804,552 (GRCm39)	V240A	probably benign	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,706,684 (GRCm39)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,706,555 (GRCm39)	missense	probably benign
IGL01073:Vmn2r23	APN	6	123,689,759 (GRCm39)	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123,681,383 (GRCm39)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,681,366 (GRCm39)	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123,718,845 (GRCm39)	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123,718,819 (GRCm39)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,718,703 (GRCm39)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,718,795 (GRCm39)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,681,437 (GRCm39)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,681,344 (GRCm39)	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123,681,355 (GRCm39)	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123,718,578 (GRCm39)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,718,741 (GRCm39)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,681,333 (GRCm39)	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123,706,585 (GRCm39)	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,706,680 (GRCm39)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,719,094 (GRCm39)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,718,963 (GRCm39)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,690,229 (GRCm39)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,690,386 (GRCm39)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,706,649 (GRCm39)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,679,874 (GRCm39)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,689,969 (GRCm39)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,718,458 (GRCm39)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,681,384 (GRCm39)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,719,147 (GRCm39)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,690,129 (GRCm39)	missense	possibly damaging	0.81
R4164:Vmn2r23	UTSW	6	123,706,697 (GRCm39)	missense	probably benign
R4506:Vmn2r23	UTSW	6	123,679,884 (GRCm39)	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123,718,689 (GRCm39)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,718,785 (GRCm39)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,710,308 (GRCm39)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,689,961 (GRCm39)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,689,718 (GRCm39)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123,689,901 (GRCm39)	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123,718,854 (GRCm39)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,681,359 (GRCm39)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,689,861 (GRCm39)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,690,384 (GRCm39)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,681,512 (GRCm39)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,689,981 (GRCm39)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,718,540 (GRCm39)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,681,538 (GRCm39)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,681,500 (GRCm39)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,718,312 (GRCm39)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,681,599 (GRCm39)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,718,615 (GRCm39)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,690,431 (GRCm39)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,679,991 (GRCm39)	missense
R8966:Vmn2r23	UTSW	6	123,719,079 (GRCm39)	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123,719,038 (GRCm39)	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123,718,782 (GRCm39)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,690,075 (GRCm39)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,690,120 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,719,067 (GRCm39)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,706,684 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- CACAGTGACTATAACCAGGGAC -3'
(R):5'- GACTGTTCCAGGTTGGCCAATG -3'

Sequencing Primer
(F):5'- GTGACTATAACCAGGGACCTTTC -3'
(R):5'- GGTTGGCCAATGAATATTAATGAGC -3'

Posted On

2015-03-25