Incidental Mutation 'IGL00933:Orm2'
ID27260
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Orm2
Ensembl Gene ENSMUSG00000061540
Gene Nameorosomucoid 2
SynonymsOrm-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL00933
Quality Score
Status
Chromosome4
Chromosomal Location63362449-63365878 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 63364152 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000074810 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006687] [ENSMUST00000035724] [ENSMUST00000075341]
Predicted Effect probably benign
Transcript: ENSMUST00000006687
SMART Domains Protein: ENSMUSP00000006687
Gene: ENSMUSG00000028359

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Lipocalin 40 180 4.8e-25 PFAM
low complexity region 185 199 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000035724
SMART Domains Protein: ENSMUSP00000041614
Gene: ENSMUSG00000039158

DomainStartEndE-ValueType
low complexity region 140 153 N/A INTRINSIC
coiled coil region 423 458 N/A INTRINSIC
Pfam:AKNA 584 681 4.6e-37 PFAM
low complexity region 760 774 N/A INTRINSIC
low complexity region 1015 1029 N/A INTRINSIC
coiled coil region 1044 1066 N/A INTRINSIC
low complexity region 1296 1317 N/A INTRINSIC
low complexity region 1319 1343 N/A INTRINSIC
coiled coil region 1353 1386 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000075341
SMART Domains Protein: ENSMUSP00000074810
Gene: ENSMUSG00000061540

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Lipocalin 41 181 1.5e-23 PFAM
low complexity region 186 200 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arrdc3 T A 13: 80,891,055 probably benign Het
Brca2 A G 5: 150,542,404 S1878G probably benign Het
Cpa6 T C 1: 10,337,370 H314R probably benign Het
Ehbp1l1 A G 19: 5,717,933 I1114T probably benign Het
Eml3 G A 19: 8,936,398 W73* probably null Het
Fmo4 G T 1: 162,794,023 Q540K probably benign Het
Fstl4 G A 11: 53,186,761 G782R possibly damaging Het
Itga11 T C 9: 62,769,305 I925T possibly damaging Het
Itsn2 T G 12: 4,707,540 F1411C probably damaging Het
Lmna A T 3: 88,482,549 C590S possibly damaging Het
Magi3 A G 3: 104,015,847 Y1185H probably benign Het
Marf1 A G 16: 14,117,357 Y1516H probably damaging Het
Mast4 T C 13: 102,735,366 D2306G probably damaging Het
Ncoa6 A G 2: 155,415,397 V742A probably damaging Het
Nol4l A G 2: 153,477,936 F175S probably damaging Het
Olfr826 A T 10: 130,180,214 M222K probably benign Het
Pik3cb T A 9: 99,101,286 T90S probably damaging Het
Plekhg2 G A 7: 28,360,689 P1072S probably benign Het
Rgr A T 14: 37,038,918 Y227* probably null Het
Snd1 T C 6: 28,512,986 probably null Het
Zfp560 A G 9: 20,348,808 S253P probably benign Het
Other mutations in Orm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01369:Orm2 APN 4 63362978 missense probably benign 0.00
IGL02321:Orm2 APN 4 63362992 missense probably damaging 0.99
IGL02401:Orm2 APN 4 63363331 missense probably benign
IGL02666:Orm2 APN 4 63365733 missense possibly damaging 0.91
R0383:Orm2 UTSW 4 63363996 missense probably damaging 1.00
R4157:Orm2 UTSW 4 63363985 missense probably null 0.92
R4615:Orm2 UTSW 4 63363299 missense probably damaging 0.99
R6363:Orm2 UTSW 4 63362604 critical splice donor site probably null
R6791:Orm2 UTSW 4 63363959 missense probably benign 0.00
R8301:Orm2 UTSW 4 63363026 missense possibly damaging 0.80
X0024:Orm2 UTSW 4 63364197 missense probably benign 0.28
Posted On2013-04-17