Incidental Mutation 'R3792:Or2m12'
ID 272609
Institutional Source Beutler Lab
Gene Symbol Or2m12
Ensembl Gene ENSMUSG00000050742
Gene Name olfactory receptor family 2 subfamily M member 12
Synonyms MOR279-2, GA_x54KRFPKG5P-15738260-15737319, Olfr164
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R3792 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 19104544-19105491 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19104696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 266 (S266P)
Ref Sequence ENSEMBL: ENSMUSP00000149971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056727] [ENSMUST00000216157]
AlphaFold Q8VF87
Predicted Effect possibly damaging
Transcript: ENSMUST00000056727
AA Change: S266P

PolyPhen 2 Score 0.537 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000056970
Gene: ENSMUSG00000050742
AA Change: S266P

DomainStartEndE-ValueType
Pfam:7tm_4 32 311 2.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 38 308 8.2e-8 PFAM
Pfam:7tm_1 44 293 5.9e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216157
AA Change: S266P

PolyPhen 2 Score 0.537 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930595M18Rik A G X: 80,464,423 (GRCm39) V428A probably benign Het
Aanat T C 11: 116,487,057 (GRCm39) L88P probably damaging Het
Arhgap5 A T 12: 52,566,671 (GRCm39) N1214I probably benign Het
BC034090 A T 1: 155,117,543 (GRCm39) S192T probably damaging Het
Bco1 G A 8: 117,857,415 (GRCm39) V461I possibly damaging Het
Cass4 C T 2: 172,274,478 (GRCm39) P753L probably damaging Het
Cripto C T 9: 110,772,258 (GRCm39) R46Q probably benign Het
Cubn G A 2: 13,432,725 (GRCm39) R1199C probably damaging Het
Dcaf12l1 T C X: 43,877,313 (GRCm39) N495S possibly damaging Het
Dop1b C A 16: 93,568,734 (GRCm39) Q1599K possibly damaging Het
Dyrk1a C A 16: 94,485,933 (GRCm39) L427I probably benign Het
Esp16 T C 17: 39,848,739 (GRCm39) I11T possibly damaging Het
Esyt3 A T 9: 99,197,334 (GRCm39) F832Y possibly damaging Het
F8 A T X: 74,328,971 (GRCm39) probably null Het
Fam135a T C 1: 24,067,392 (GRCm39) Y259C probably benign Het
Fbxo38 T C 18: 62,666,533 (GRCm39) probably null Het
Fbxo43 T C 15: 36,163,005 (GRCm39) I67M probably benign Het
Gcfc2 G T 6: 81,907,748 (GRCm39) C154F probably benign Het
Hipk2 C T 6: 38,675,491 (GRCm39) R1029H probably damaging Het
Ilk G A 7: 105,391,294 (GRCm39) W73* probably null Het
Ism1 T C 2: 139,582,173 (GRCm39) S162P probably damaging Het
Itpkb T A 1: 180,160,738 (GRCm39) L288Q possibly damaging Het
Itpr2 C A 6: 146,316,852 (GRCm39) K306N probably damaging Het
Kdm2a C T 19: 4,374,540 (GRCm39) E864K possibly damaging Het
Kdm4b G A 17: 56,662,944 (GRCm39) V172M probably damaging Het
Kyat3 A T 3: 142,443,605 (GRCm39) K406M probably null Het
Lipe T A 7: 25,097,045 (GRCm39) K299N possibly damaging Het
Lrrc2 T A 9: 110,795,585 (GRCm39) C123* probably null Het
Mptx2 T A 1: 173,102,240 (GRCm39) I150F probably damaging Het
Mroh2b G T 15: 4,953,102 (GRCm39) W612L probably damaging Het
Mucl2 T C 15: 103,928,692 (GRCm39) T27A possibly damaging Het
Nfx1 T A 4: 41,004,357 (GRCm39) C709* probably null Het
Oprm1 T C 10: 6,789,544 (GRCm39) S390P probably benign Het
Or51v8 A T 7: 103,319,353 (GRCm39) I295N probably damaging Het
Pcdhb14 T C 18: 37,582,715 (GRCm39) L607P probably damaging Het
Rap1gds1 A T 3: 138,671,721 (GRCm39) I133N probably damaging Het
Rasl10a T C 11: 5,009,461 (GRCm39) L83S probably damaging Het
Satb2 C T 1: 56,884,779 (GRCm39) V382M probably damaging Het
Sh3gl1 T C 17: 56,325,949 (GRCm39) K160R probably damaging Het
Sirt4 T C 5: 115,618,351 (GRCm39) D241G probably benign Het
Sla2 G A 2: 156,717,862 (GRCm39) R137C probably damaging Het
Spef2 A G 15: 9,704,622 (GRCm39) I454T probably damaging Het
Stag3 A G 5: 138,296,611 (GRCm39) K490E probably benign Het
Tcstv7b G T 13: 120,702,467 (GRCm39) V88F probably damaging Het
Tctn3 T C 19: 40,600,155 (GRCm39) K95R probably benign Het
Trp53bp1 T C 2: 121,030,810 (GRCm39) I1784V probably damaging Het
Ttc21a A T 9: 119,783,231 (GRCm39) E511V probably damaging Het
Ttn A G 2: 76,542,232 (GRCm39) F25258L probably damaging Het
Ttn A C 2: 76,639,290 (GRCm39) C13828G probably damaging Het
Vmn1r210 T A 13: 23,011,573 (GRCm39) M238L probably damaging Het
Vmn1r38 A G 6: 66,753,891 (GRCm39) I75T probably benign Het
Vmn2r84 T A 10: 130,221,669 (GRCm39) *850C probably null Het
Vwa7 T C 17: 35,244,135 (GRCm39) probably null Het
Zfp128 T A 7: 12,618,659 (GRCm39) D52E probably damaging Het
Zfp618 T C 4: 63,033,728 (GRCm39) probably benign Het
Zkscan2 T A 7: 123,084,225 (GRCm39) E633V possibly damaging Het
Other mutations in Or2m12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01529:Or2m12 APN 16 19,105,450 (GRCm39) missense probably benign 0.01
IGL01569:Or2m12 APN 16 19,105,410 (GRCm39) missense probably benign 0.28
IGL01619:Or2m12 APN 16 19,104,909 (GRCm39) missense probably damaging 1.00
IGL02101:Or2m12 APN 16 19,105,363 (GRCm39) missense probably benign
IGL02201:Or2m12 APN 16 19,105,212 (GRCm39) missense probably benign 0.03
IGL02730:Or2m12 APN 16 19,105,432 (GRCm39) missense probably benign 0.00
IGL03228:Or2m12 APN 16 19,105,140 (GRCm39) missense probably damaging 1.00
R1566:Or2m12 UTSW 16 19,105,077 (GRCm39) missense possibly damaging 0.76
R1817:Or2m12 UTSW 16 19,104,627 (GRCm39) missense probably damaging 1.00
R1870:Or2m12 UTSW 16 19,105,357 (GRCm39) missense probably damaging 1.00
R1918:Or2m12 UTSW 16 19,105,052 (GRCm39) missense probably benign 0.03
R2202:Or2m12 UTSW 16 19,105,047 (GRCm39) missense probably benign 0.03
R2265:Or2m12 UTSW 16 19,105,305 (GRCm39) missense probably damaging 1.00
R4285:Or2m12 UTSW 16 19,104,714 (GRCm39) missense probably damaging 1.00
R4961:Or2m12 UTSW 16 19,104,726 (GRCm39) missense probably damaging 1.00
R5022:Or2m12 UTSW 16 19,104,809 (GRCm39) missense probably damaging 1.00
R5432:Or2m12 UTSW 16 19,104,839 (GRCm39) missense probably benign 0.06
R5827:Or2m12 UTSW 16 19,105,182 (GRCm39) missense probably benign 0.24
R6154:Or2m12 UTSW 16 19,105,181 (GRCm39) missense probably damaging 0.99
R6188:Or2m12 UTSW 16 19,105,307 (GRCm39) missense probably damaging 1.00
R6367:Or2m12 UTSW 16 19,104,822 (GRCm39) missense probably damaging 1.00
R8508:Or2m12 UTSW 16 19,105,451 (GRCm39) missense probably benign 0.01
R8523:Or2m12 UTSW 16 19,104,851 (GRCm39) missense probably benign 0.13
R8902:Or2m12 UTSW 16 19,105,383 (GRCm39) missense probably damaging 0.98
R8953:Or2m12 UTSW 16 19,105,269 (GRCm39) missense probably benign 0.27
R9313:Or2m12 UTSW 16 19,105,100 (GRCm39) missense probably benign 0.00
R9542:Or2m12 UTSW 16 19,104,943 (GRCm39) missense probably benign 0.01
R9651:Or2m12 UTSW 16 19,105,489 (GRCm39) start codon destroyed probably null
Predicted Primers PCR Primer
(F):5'- AGCATGCCCAAGAACTTAGAG -3'
(R):5'- GTGGTGCCAGAGAAATACCTC -3'

Sequencing Primer
(F):5'- GCATAAAAATCAGCTAACTCATGCTG -3'
(R):5'- GCCTTACTCACACTTTCATGTAG -3'
Posted On 2015-03-25