Incidental Mutation 'R3767:Agmat'
ID 273045
Institutional Source Beutler Lab
Gene Symbol Agmat
Ensembl Gene ENSMUSG00000040706
Gene Name agmatinase
Synonyms 5033405N08Rik
MMRRC Submission 040744-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R3767 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 141473986-141486574 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 141483273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 236 (T236A)
Ref Sequence ENSEMBL: ENSMUSP00000040853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038014] [ENSMUST00000038161]
AlphaFold A2AS89
Predicted Effect probably benign
Transcript: ENSMUST00000038014
SMART Domains Protein: ENSMUSP00000048714
Gene: ENSMUSG00000040697

DomainStartEndE-ValueType
DnaJ 28 85 4.5e-30 SMART
Pfam:Thioredoxin 142 243 4.4e-8 PFAM
low complexity region 537 549 N/A INTRINSIC
low complexity region 730 750 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000038161
AA Change: T236A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000040853
Gene: ENSMUSG00000040706
AA Change: T236A

DomainStartEndE-ValueType
low complexity region 44 62 N/A INTRINSIC
Pfam:Arginase 77 351 9.8e-85 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adipoq T A 16: 22,975,938 (GRCm39) V134E possibly damaging Het
Anxa9 T C 3: 95,208,425 (GRCm39) N197S probably benign Het
Arhgap23 A T 11: 97,366,932 (GRCm39) D1071V probably damaging Het
Axdnd1 G A 1: 156,208,428 (GRCm39) T470M probably damaging Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cdh3 A T 8: 107,263,606 (GRCm39) probably null Het
Cep85l A T 10: 53,167,906 (GRCm39) I624K probably benign Het
Cplx4 T C 18: 66,102,998 (GRCm39) T41A probably benign Het
Dchs1 A T 7: 105,406,292 (GRCm39) D2313E possibly damaging Het
Dock7 T C 4: 98,859,066 (GRCm39) T1409A probably benign Het
Exo1 C T 1: 175,714,312 (GRCm39) P73L probably damaging Het
Fgfrl1 C A 5: 108,853,242 (GRCm39) H197Q possibly damaging Het
Fsbp G A 4: 11,583,706 (GRCm39) G135D probably damaging Het
Herc3 G A 6: 58,839,973 (GRCm39) R362H probably benign Het
Herc3 T C 6: 58,853,587 (GRCm39) F583L probably benign Het
Ifna7 T C 4: 88,734,964 (GRCm39) V167A probably damaging Het
Ighv1-54 A G 12: 115,157,596 (GRCm39) V17A possibly damaging Het
Kcnh5 A G 12: 75,134,350 (GRCm39) Y400H possibly damaging Het
Kcnk16 T A 14: 20,319,230 (GRCm39) M1L possibly damaging Het
Kctd19 T C 8: 106,123,112 (GRCm39) T101A probably benign Het
Klf3 A G 5: 64,984,560 (GRCm39) probably null Het
Krtap12-1 G T 10: 77,556,729 (GRCm39) V91L probably benign Het
Lonp1 T C 17: 56,928,952 (GRCm39) E270G possibly damaging Het
Mgl2 T C 11: 70,026,659 (GRCm39) L128P probably damaging Het
Mrc1 A G 2: 14,323,981 (GRCm39) Y1106C probably damaging Het
Mybpc1 G T 10: 88,406,521 (GRCm39) probably null Het
Mypn C A 10: 62,961,486 (GRCm39) L1035F possibly damaging Het
Neurl1a T C 19: 47,228,328 (GRCm39) L58P probably damaging Het
Nlrp4e G T 7: 23,039,988 (GRCm39) L770F probably damaging Het
Npas3 A G 12: 54,115,857 (GRCm39) *895W probably null Het
Nphs2 T C 1: 156,140,608 (GRCm39) I115T probably damaging Het
Or1ad6 A G 11: 50,860,385 (GRCm39) D180G probably damaging Het
Or8g22 T A 9: 38,958,707 (GRCm39) H47L unknown Het
Patj A T 4: 98,569,456 (GRCm39) K1128* probably null Het
Pla2g5 C G 4: 138,528,746 (GRCm39) C70S probably damaging Het
Pole4 G A 6: 82,599,095 (GRCm39) R119C possibly damaging Het
Ppm1h G T 10: 122,740,027 (GRCm39) L367F probably damaging Het
Ppp1r13b G T 12: 111,812,851 (GRCm39) R123S probably damaging Het
Ptpru C T 4: 131,535,735 (GRCm39) C414Y probably damaging Het
Pum2 T A 12: 8,769,076 (GRCm39) Y323* probably null Het
Rhot2 T C 17: 26,059,521 (GRCm39) D407G probably benign Het
Rreb1 C T 13: 38,113,579 (GRCm39) R313W possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Scn11a T A 9: 119,613,115 (GRCm39) D825V probably damaging Het
Selenoi A G 5: 30,461,187 (GRCm39) Y141C probably damaging Het
Smcr8 A G 11: 60,670,330 (GRCm39) T493A probably benign Het
Tjp2 A T 19: 24,078,190 (GRCm39) I901N probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Ttc23l T A 15: 10,530,781 (GRCm39) Y277F possibly damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Wdr1 C T 5: 38,697,882 (GRCm39) G228R probably damaging Het
Xab2 T C 8: 3,669,053 (GRCm39) N31S probably damaging Het
Other mutations in Agmat
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02870:Agmat APN 4 141,474,253 (GRCm39) missense probably benign 0.02
3-1:Agmat UTSW 4 141,476,921 (GRCm39) missense possibly damaging 0.49
3-1:Agmat UTSW 4 141,476,893 (GRCm39) missense probably damaging 1.00
R1635:Agmat UTSW 4 141,474,380 (GRCm39) missense probably damaging 1.00
R2103:Agmat UTSW 4 141,483,214 (GRCm39) missense probably damaging 0.97
R2215:Agmat UTSW 4 141,476,899 (GRCm39) missense probably benign 0.01
R4379:Agmat UTSW 4 141,484,802 (GRCm39) missense probably benign 0.10
R5422:Agmat UTSW 4 141,483,144 (GRCm39) missense probably damaging 1.00
R5640:Agmat UTSW 4 141,483,134 (GRCm39) missense probably damaging 1.00
R5750:Agmat UTSW 4 141,476,998 (GRCm39) missense probably benign 0.03
R6728:Agmat UTSW 4 141,476,897 (GRCm39) missense probably benign 0.00
R6891:Agmat UTSW 4 141,483,192 (GRCm39) missense probably benign 0.01
R7293:Agmat UTSW 4 141,483,246 (GRCm39) nonsense probably null
R7298:Agmat UTSW 4 141,474,275 (GRCm39) missense possibly damaging 0.90
R7361:Agmat UTSW 4 141,474,163 (GRCm39) missense probably benign 0.23
R7585:Agmat UTSW 4 141,477,056 (GRCm39) missense probably benign 0.09
R8832:Agmat UTSW 4 141,474,320 (GRCm39) missense probably benign 0.08
R9288:Agmat UTSW 4 141,474,391 (GRCm39) missense probably damaging 1.00
R9400:Agmat UTSW 4 141,476,981 (GRCm39) missense probably damaging 1.00
Z1177:Agmat UTSW 4 141,474,290 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- ACCTCTGAGATGCCGTTTTC -3'
(R):5'- TCTTGCCACATGAGTCACTTG -3'

Sequencing Primer
(F):5'- GAGAAGGTCTACCATCGG -3'
(R):5'- CTGGGAATCAAACTCAGGTTCTC -3'
Posted On 2015-03-25