Incidental Mutation 'R3768:Or2y14'
ID 273125
Institutional Source Beutler Lab
Gene Symbol Or2y14
Ensembl Gene ENSMUSG00000044170
Gene Name olfactory receptor family 2 subfamily Y member 14
Synonyms Olfr1384, MOR256-23, GA_x6K02T2QP88-5922712-5921756
MMRRC Submission 040745-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R3768 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 49404445-49405478 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 49404600 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 45 (I45T)
Ref Sequence ENSEMBL: ENSMUSP00000149183 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060434] [ENSMUST00000213776]
AlphaFold Q8VFA8
Predicted Effect probably damaging
Transcript: ENSMUST00000060434
AA Change: I45T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000051954
Gene: ENSMUSG00000044170
AA Change: I45T

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 6.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 34 161 4.3e-6 PFAM
Pfam:7tm_1 40 313 2.7e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213776
AA Change: I45T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Meta Mutation Damage Score 0.2856 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 T C 11: 110,204,217 (GRCm39) R353G probably benign Het
Ank1 A G 8: 23,606,202 (GRCm39) D1153G possibly damaging Het
Ankrd12 T C 17: 66,292,715 (GRCm39) Y906C probably benign Het
Apol9a G C 15: 77,288,596 (GRCm39) T257S probably benign Het
Arhgap23 A T 11: 97,366,932 (GRCm39) D1071V probably damaging Het
Arid4a A G 12: 71,113,893 (GRCm39) K160R probably damaging Het
Atp8a2 T A 14: 60,281,785 (GRCm39) H142L probably benign Het
B3gnt2 T C 11: 22,786,765 (GRCm39) K141R probably damaging Het
Btbd7 G A 12: 102,761,451 (GRCm39) P578L probably damaging Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cmya5 A T 13: 93,233,201 (GRCm39) I629K possibly damaging Het
Cnga4 A G 7: 105,056,887 (GRCm39) N330S probably damaging Het
Cplx4 T C 18: 66,102,998 (GRCm39) T41A probably benign Het
Cxcl15 A C 5: 90,949,303 (GRCm39) D156A unknown Het
D630045J12Rik A G 6: 38,119,844 (GRCm39) S1633P probably damaging Het
Dock10 T A 1: 80,510,085 (GRCm39) N1581I probably damaging Het
Dock7 T C 4: 98,859,066 (GRCm39) T1409A probably benign Het
Dscaml1 T A 9: 45,643,435 (GRCm39) F1285I possibly damaging Het
Fgf10 G T 13: 118,918,083 (GRCm39) V124F probably damaging Het
Ifna7 T C 4: 88,734,964 (GRCm39) V167A probably damaging Het
Kctd19 T C 8: 106,123,112 (GRCm39) T101A probably benign Het
Klf3 A G 5: 64,984,560 (GRCm39) probably null Het
Krtap12-1 G T 10: 77,556,729 (GRCm39) V91L probably benign Het
Lrp2 C T 2: 69,335,449 (GRCm39) D1425N probably benign Het
Mgl2 T C 11: 70,026,659 (GRCm39) L128P probably damaging Het
Mypn C A 10: 62,961,486 (GRCm39) L1035F possibly damaging Het
Ncor2 A G 5: 125,105,751 (GRCm39) V1613A probably damaging Het
Nlgn2 C T 11: 69,719,230 (GRCm39) V207I possibly damaging Het
Or10v1 G A 19: 11,873,676 (GRCm39) G97D probably damaging Het
Or1ad6 A G 11: 50,860,385 (GRCm39) D180G probably damaging Het
Or4d10c A G 19: 12,065,304 (GRCm39) I284T probably damaging Het
Osbpl3 G A 6: 50,324,982 (GRCm39) P172L possibly damaging Het
Pabpc4 T A 4: 123,188,405 (GRCm39) V338D probably damaging Het
Pdia6 T C 12: 17,320,457 (GRCm39) V32A probably damaging Het
Pik3c3 T A 18: 30,466,326 (GRCm39) S792R probably damaging Het
Pla2g5 C G 4: 138,528,746 (GRCm39) C70S probably damaging Het
Pole4 G A 6: 82,599,095 (GRCm39) R119C possibly damaging Het
Ppm1h G T 10: 122,740,027 (GRCm39) L367F probably damaging Het
Ptpru C T 4: 131,535,735 (GRCm39) C414Y probably damaging Het
Rhot2 T C 17: 26,059,521 (GRCm39) D407G probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sap25 T A 5: 137,640,632 (GRCm39) F171I probably damaging Het
Serpinb11 T C 1: 107,305,392 (GRCm39) probably null Het
Tarm1 A T 7: 3,546,097 (GRCm39) S69T probably benign Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Usp36 T C 11: 118,153,878 (GRCm39) K846R probably damaging Het
Zfp229 A T 17: 21,964,844 (GRCm39) H358L probably damaging Het
Zfp747l1 A G 7: 126,984,035 (GRCm39) probably benign Het
Other mutations in Or2y14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02212:Or2y14 APN 11 49,404,737 (GRCm39) missense probably damaging 0.98
IGL02972:Or2y14 APN 11 49,404,918 (GRCm39) missense probably damaging 1.00
R0157:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R1106:Or2y14 UTSW 11 49,404,519 (GRCm39) missense probably damaging 1.00
R1213:Or2y14 UTSW 11 49,405,421 (GRCm39) makesense probably null
R4191:Or2y14 UTSW 11 49,404,639 (GRCm39) missense probably damaging 1.00
R4708:Or2y14 UTSW 11 49,405,216 (GRCm39) nonsense probably null
R5443:Or2y14 UTSW 11 49,405,262 (GRCm39) missense probably damaging 0.98
R5770:Or2y14 UTSW 11 49,405,419 (GRCm39) missense unknown
R6245:Or2y14 UTSW 11 49,404,992 (GRCm39) missense possibly damaging 0.94
R6336:Or2y14 UTSW 11 49,405,369 (GRCm39) missense probably damaging 0.99
R7652:Or2y14 UTSW 11 49,404,512 (GRCm39) missense probably damaging 1.00
R8070:Or2y14 UTSW 11 49,404,941 (GRCm39) missense probably damaging 1.00
R8147:Or2y14 UTSW 11 49,405,050 (GRCm39) missense probably benign 0.02
R9289:Or2y14 UTSW 11 49,404,635 (GRCm39) missense probably damaging 1.00
R9551:Or2y14 UTSW 11 49,404,942 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCTGGACCATCTATGTGTCTG -3'
(R):5'- AGTTCCACCCAGTAAGAGTGC -3'

Sequencing Primer
(F):5'- CTGTTGGTAGGCTTCTCAG -3'
(R):5'- TTCCACCCAGTAAGAGTGCTATGAAG -3'
Posted On 2015-03-25