Incidental Mutation 'R3771:Tex2'
ID 273297
Institutional Source Beutler Lab
Gene Symbol Tex2
Ensembl Gene ENSMUSG00000040548
Gene Name testis expressed gene 2
Synonyms 4930568E07Rik, Taz4, Def-5
MMRRC Submission 040747-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3771 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 106392973-106504249 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 106437720 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 650 (D650G)
Ref Sequence ENSEMBL: ENSMUSP00000099359 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042780] [ENSMUST00000103070]
AlphaFold Q6ZPJ0
Predicted Effect unknown
Transcript: ENSMUST00000042780
AA Change: D650G
SMART Domains Protein: ENSMUSP00000041985
Gene: ENSMUSG00000040548
AA Change: D650G

DomainStartEndE-ValueType
low complexity region 119 186 N/A INTRINSIC
low complexity region 319 341 N/A INTRINSIC
low complexity region 346 360 N/A INTRINSIC
transmembrane domain 473 492 N/A INTRINSIC
transmembrane domain 494 516 N/A INTRINSIC
PH 543 712 5.05e-1 SMART
low complexity region 732 752 N/A INTRINSIC
low complexity region 811 823 N/A INTRINSIC
low complexity region 946 965 N/A INTRINSIC
low complexity region 1003 1016 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000103070
AA Change: D650G
SMART Domains Protein: ENSMUSP00000099359
Gene: ENSMUSG00000040548
AA Change: D650G

DomainStartEndE-ValueType
low complexity region 119 186 N/A INTRINSIC
low complexity region 319 341 N/A INTRINSIC
low complexity region 346 360 N/A INTRINSIC
transmembrane domain 473 492 N/A INTRINSIC
transmembrane domain 494 516 N/A INTRINSIC
PH 543 712 5.05e-1 SMART
low complexity region 732 752 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000207249
AA Change: D152G
Meta Mutation Damage Score 0.0615 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 99% (69/70)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat G T 11: 116,487,697 (GRCm39) G132V probably damaging Het
Abcb11 T A 2: 69,159,720 (GRCm39) probably benign Het
Adam26b T A 8: 43,973,751 (GRCm39) D417V probably damaging Het
Ank1 T C 8: 23,613,913 (GRCm39) S1482P probably benign Het
Aoc1l2 T C 6: 48,908,130 (GRCm39) Y377H probably damaging Het
Armc2 C T 10: 41,798,223 (GRCm39) V768M probably damaging Het
Ascc3 C T 10: 50,596,814 (GRCm39) probably benign Het
Birc6 T A 17: 74,925,424 (GRCm39) probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cdh12 A T 15: 21,578,640 (GRCm39) probably benign Het
Chd1 A G 17: 17,594,913 (GRCm39) D16G probably damaging Het
Clstn2 A G 9: 97,464,615 (GRCm39) I180T probably damaging Het
Cxcr6 A G 9: 123,639,550 (GRCm39) I184V probably benign Het
Dagla G A 19: 10,225,831 (GRCm39) P778S possibly damaging Het
Ddx19b T C 8: 111,747,613 (GRCm39) K107R probably benign Het
Dpyd G A 3: 119,205,927 (GRCm39) probably null Het
Elf1 T C 14: 79,804,650 (GRCm39) V105A possibly damaging Het
Fam13a T G 6: 58,964,171 (GRCm39) K87T probably benign Het
Fap C A 2: 62,363,354 (GRCm39) S359I probably damaging Het
Fbxo39 T C 11: 72,208,041 (GRCm39) I131T possibly damaging Het
Fmn1 T G 2: 113,412,463 (GRCm39) S996A probably damaging Het
Gm5866 T C 5: 52,740,088 (GRCm39) noncoding transcript Het
Hmcn2 C T 2: 31,250,908 (GRCm39) T790M probably damaging Het
Irf2bp2 T C 8: 127,318,550 (GRCm39) K339E probably damaging Het
Kat6b A G 14: 21,567,166 (GRCm39) D75G probably damaging Het
Kcnab3 A G 11: 69,219,389 (GRCm39) T127A probably damaging Het
Kdm5b G T 1: 134,541,083 (GRCm39) C725F probably damaging Het
Lrp5 G A 19: 3,662,330 (GRCm39) R173C probably damaging Het
Lrrn3 T A 12: 41,502,869 (GRCm39) I483L probably damaging Het
Man2c1 C A 9: 57,047,661 (GRCm39) probably benign Het
Med23 G T 10: 24,778,099 (GRCm39) G810C probably damaging Het
Nhlrc4 T A 17: 26,162,367 (GRCm39) K127* probably null Het
Numb T C 12: 83,846,350 (GRCm39) D344G probably damaging Het
Nup210l T G 3: 90,027,201 (GRCm39) Y194* probably null Het
Ogg1 T C 6: 113,310,804 (GRCm39) V317A possibly damaging Het
Or1o2 T A 17: 37,542,356 (GRCm39) I302F possibly damaging Het
Or6c69c A G 10: 129,911,143 (GRCm39) Y288C probably damaging Het
Pclo A T 5: 14,589,422 (GRCm39) probably null Het
Pnpt1 T C 11: 29,088,174 (GRCm39) M195T probably benign Het
Polr3c T A 3: 96,633,170 (GRCm39) T43S probably damaging Het
Ptprs T C 17: 56,735,978 (GRCm39) T152A possibly damaging Het
Rasl10b A T 11: 83,309,349 (GRCm39) T134S probably benign Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rnf39 T C 17: 37,258,121 (GRCm39) W96R probably damaging Het
Ros1 G T 10: 52,005,087 (GRCm39) A949E probably damaging Het
Rwdd2a A C 9: 86,456,214 (GRCm39) N130T possibly damaging Het
Scn9a T C 2: 66,313,992 (GRCm39) N1909D probably benign Het
Shisal1 A T 15: 84,290,886 (GRCm39) Y120* probably null Het
Ska3 C T 14: 58,047,534 (GRCm39) V334I probably benign Het
Srebf2 A G 15: 82,066,309 (GRCm39) K579R probably benign Het
Sun1 A G 5: 139,224,575 (GRCm39) probably benign Het
Tc2n T A 12: 101,660,833 (GRCm39) Q133L possibly damaging Het
Tecta T C 9: 42,242,292 (GRCm39) T2094A probably damaging Het
Trio A G 15: 27,748,177 (GRCm39) S2492P probably damaging Het
Ttn T C 2: 76,601,711 (GRCm39) T16872A probably benign Het
Ugcg T C 4: 59,189,690 (GRCm39) F16S probably benign Het
Usp16 T C 16: 87,255,571 (GRCm39) M1T probably null Het
Vmn1r60 C A 7: 5,547,710 (GRCm39) C130F possibly damaging Het
Vmn2r101 A G 17: 19,809,919 (GRCm39) D235G probably benign Het
Vpreb3 A T 10: 75,775,800 (GRCm39) V26E probably benign Het
Vps39 C T 2: 120,172,497 (GRCm39) V179I possibly damaging Het
Xrn2 T C 2: 146,903,207 (GRCm39) V765A probably benign Het
Zfp251 A G 15: 76,737,836 (GRCm39) I414T possibly damaging Het
Zfp426 A T 9: 20,384,413 (GRCm39) probably null Het
Zfp61 T C 7: 23,995,406 (GRCm39) M1V probably null Het
Other mutations in Tex2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Tex2 APN 11 106,459,361 (GRCm39) missense probably damaging 1.00
IGL01380:Tex2 APN 11 106,435,141 (GRCm39) nonsense probably null
IGL02607:Tex2 APN 11 106,437,573 (GRCm39) missense unknown
IGL02680:Tex2 APN 11 106,459,058 (GRCm39) unclassified probably benign
IGL02699:Tex2 APN 11 106,459,259 (GRCm39) missense possibly damaging 0.53
IGL03187:Tex2 APN 11 106,458,903 (GRCm39) unclassified probably benign
IGL03398:Tex2 APN 11 106,459,098 (GRCm39) missense probably damaging 1.00
R0242:Tex2 UTSW 11 106,410,781 (GRCm39) nonsense probably null
R0242:Tex2 UTSW 11 106,410,781 (GRCm39) nonsense probably null
R1085:Tex2 UTSW 11 106,459,313 (GRCm39) missense probably damaging 0.98
R1491:Tex2 UTSW 11 106,394,466 (GRCm39) missense possibly damaging 0.72
R1664:Tex2 UTSW 11 106,458,608 (GRCm39) unclassified probably benign
R1794:Tex2 UTSW 11 106,458,728 (GRCm39) unclassified probably benign
R1855:Tex2 UTSW 11 106,437,702 (GRCm39) missense possibly damaging 0.87
R2077:Tex2 UTSW 11 106,397,690 (GRCm39) splice site probably null
R2151:Tex2 UTSW 11 106,458,161 (GRCm39) unclassified probably benign
R2175:Tex2 UTSW 11 106,394,513 (GRCm39) missense unknown
R2984:Tex2 UTSW 11 106,437,489 (GRCm39) critical splice donor site probably null
R3156:Tex2 UTSW 11 106,424,695 (GRCm39) critical splice donor site probably null
R3722:Tex2 UTSW 11 106,437,566 (GRCm39) nonsense probably null
R3724:Tex2 UTSW 11 106,420,156 (GRCm39) missense unknown
R3770:Tex2 UTSW 11 106,435,078 (GRCm39) missense unknown
R3813:Tex2 UTSW 11 106,402,770 (GRCm39) missense unknown
R3947:Tex2 UTSW 11 106,410,829 (GRCm39) missense unknown
R4206:Tex2 UTSW 11 106,458,398 (GRCm39) unclassified probably benign
R4342:Tex2 UTSW 11 106,457,832 (GRCm39) unclassified probably benign
R4554:Tex2 UTSW 11 106,435,212 (GRCm39) missense unknown
R4896:Tex2 UTSW 11 106,459,230 (GRCm39) missense probably damaging 1.00
R5207:Tex2 UTSW 11 106,437,666 (GRCm39) missense unknown
R5249:Tex2 UTSW 11 106,437,615 (GRCm39) missense unknown
R5257:Tex2 UTSW 11 106,458,585 (GRCm39) unclassified probably benign
R5258:Tex2 UTSW 11 106,458,585 (GRCm39) unclassified probably benign
R5278:Tex2 UTSW 11 106,458,639 (GRCm39) missense probably benign 0.34
R5702:Tex2 UTSW 11 106,435,221 (GRCm39) missense possibly damaging 0.58
R5835:Tex2 UTSW 11 106,410,739 (GRCm39) missense unknown
R6150:Tex2 UTSW 11 106,457,906 (GRCm39) missense probably benign 0.34
R6785:Tex2 UTSW 11 106,424,776 (GRCm39) missense probably damaging 1.00
R6879:Tex2 UTSW 11 106,424,836 (GRCm39) missense unknown
R7038:Tex2 UTSW 11 106,402,726 (GRCm39) critical splice donor site probably null
R7117:Tex2 UTSW 11 106,435,071 (GRCm39) missense unknown
R7336:Tex2 UTSW 11 106,439,685 (GRCm39) missense unknown
R7568:Tex2 UTSW 11 106,439,562 (GRCm39) missense unknown
R7622:Tex2 UTSW 11 106,437,721 (GRCm39) missense unknown
R8228:Tex2 UTSW 11 106,457,997 (GRCm39) missense probably benign 0.34
R8407:Tex2 UTSW 11 106,459,221 (GRCm39) missense probably damaging 1.00
R8807:Tex2 UTSW 11 106,458,414 (GRCm39) missense unknown
R8807:Tex2 UTSW 11 106,435,194 (GRCm39) missense unknown
R8882:Tex2 UTSW 11 106,435,062 (GRCm39) missense unknown
R8926:Tex2 UTSW 11 106,459,230 (GRCm39) missense
R8936:Tex2 UTSW 11 106,458,144 (GRCm39) nonsense probably null
R8988:Tex2 UTSW 11 106,402,731 (GRCm39) missense unknown
R9165:Tex2 UTSW 11 106,458,095 (GRCm39) missense unknown
R9294:Tex2 UTSW 11 106,459,361 (GRCm39) missense probably damaging 1.00
R9314:Tex2 UTSW 11 106,435,075 (GRCm39) missense unknown
R9405:Tex2 UTSW 11 106,435,214 (GRCm39) missense unknown
R9419:Tex2 UTSW 11 106,457,835 (GRCm39) nonsense probably null
R9477:Tex2 UTSW 11 106,410,706 (GRCm39) critical splice donor site probably null
R9626:Tex2 UTSW 11 106,437,579 (GRCm39) missense unknown
R9634:Tex2 UTSW 11 106,458,978 (GRCm39) missense unknown
T0970:Tex2 UTSW 11 106,437,772 (GRCm39) missense unknown
Z1177:Tex2 UTSW 11 106,424,834 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGAGCTCTGACTTCAGCCTC -3'
(R):5'- ATTTCAGTCAAGGCCATGTGACAG -3'

Sequencing Primer
(F):5'- TCGAGGCCAGGATGAACC -3'
(R):5'- AAGGCCATGTGACAGCCTGAC -3'
Posted On 2015-03-25