Incidental Mutation 'R3771:Zfp251'
ID 273307
Institutional Source Beutler Lab
Gene Symbol Zfp251
Ensembl Gene ENSMUSG00000022526
Gene Name zinc finger protein 251
Synonyms 9130001M19Rik
MMRRC Submission 040747-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R3771 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 76736331-76755635 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 76737836 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 414 (I414T)
Ref Sequence ENSEMBL: ENSMUSP00000155649 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080406] [ENSMUST00000229494]
AlphaFold Q6PCX8
Predicted Effect possibly damaging
Transcript: ENSMUST00000080406
AA Change: I419T

PolyPhen 2 Score 0.518 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000079268
Gene: ENSMUSG00000022526
AA Change: I419T

DomainStartEndE-ValueType
KRAB 15 75 3.24e-32 SMART
ZnF_C2H2 202 224 3.69e-4 SMART
ZnF_C2H2 230 252 3.34e-2 SMART
ZnF_C2H2 258 280 1.69e-3 SMART
ZnF_C2H2 286 308 1.18e-2 SMART
ZnF_C2H2 314 336 4.94e-5 SMART
ZnF_C2H2 342 364 1.82e-3 SMART
ZnF_C2H2 370 392 2.71e-2 SMART
ZnF_C2H2 398 420 1.56e-2 SMART
ZnF_C2H2 426 448 1.2e-3 SMART
ZnF_C2H2 454 476 1.28e-3 SMART
ZnF_C2H2 482 504 1.3e-4 SMART
PDB:1MEY|G 551 610 2e-8 PDB
Blast:PHD 556 610 2e-6 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000229494
AA Change: I414T

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230315
Meta Mutation Damage Score 0.2550 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 99% (69/70)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat G T 11: 116,487,697 (GRCm39) G132V probably damaging Het
Abcb11 T A 2: 69,159,720 (GRCm39) probably benign Het
Adam26b T A 8: 43,973,751 (GRCm39) D417V probably damaging Het
Ank1 T C 8: 23,613,913 (GRCm39) S1482P probably benign Het
Aoc1l2 T C 6: 48,908,130 (GRCm39) Y377H probably damaging Het
Armc2 C T 10: 41,798,223 (GRCm39) V768M probably damaging Het
Ascc3 C T 10: 50,596,814 (GRCm39) probably benign Het
Birc6 T A 17: 74,925,424 (GRCm39) probably benign Het
Cd109 CATTTATTTATTTATTTATTTATTTATTTATTTAT CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT 9: 78,619,782 (GRCm39) probably benign Het
Cdh12 A T 15: 21,578,640 (GRCm39) probably benign Het
Chd1 A G 17: 17,594,913 (GRCm39) D16G probably damaging Het
Clstn2 A G 9: 97,464,615 (GRCm39) I180T probably damaging Het
Cxcr6 A G 9: 123,639,550 (GRCm39) I184V probably benign Het
Dagla G A 19: 10,225,831 (GRCm39) P778S possibly damaging Het
Ddx19b T C 8: 111,747,613 (GRCm39) K107R probably benign Het
Dpyd G A 3: 119,205,927 (GRCm39) probably null Het
Elf1 T C 14: 79,804,650 (GRCm39) V105A possibly damaging Het
Fam13a T G 6: 58,964,171 (GRCm39) K87T probably benign Het
Fap C A 2: 62,363,354 (GRCm39) S359I probably damaging Het
Fbxo39 T C 11: 72,208,041 (GRCm39) I131T possibly damaging Het
Fmn1 T G 2: 113,412,463 (GRCm39) S996A probably damaging Het
Gm5866 T C 5: 52,740,088 (GRCm39) noncoding transcript Het
Hmcn2 C T 2: 31,250,908 (GRCm39) T790M probably damaging Het
Irf2bp2 T C 8: 127,318,550 (GRCm39) K339E probably damaging Het
Kat6b A G 14: 21,567,166 (GRCm39) D75G probably damaging Het
Kcnab3 A G 11: 69,219,389 (GRCm39) T127A probably damaging Het
Kdm5b G T 1: 134,541,083 (GRCm39) C725F probably damaging Het
Lrp5 G A 19: 3,662,330 (GRCm39) R173C probably damaging Het
Lrrn3 T A 12: 41,502,869 (GRCm39) I483L probably damaging Het
Man2c1 C A 9: 57,047,661 (GRCm39) probably benign Het
Med23 G T 10: 24,778,099 (GRCm39) G810C probably damaging Het
Nhlrc4 T A 17: 26,162,367 (GRCm39) K127* probably null Het
Numb T C 12: 83,846,350 (GRCm39) D344G probably damaging Het
Nup210l T G 3: 90,027,201 (GRCm39) Y194* probably null Het
Ogg1 T C 6: 113,310,804 (GRCm39) V317A possibly damaging Het
Or1o2 T A 17: 37,542,356 (GRCm39) I302F possibly damaging Het
Or6c69c A G 10: 129,911,143 (GRCm39) Y288C probably damaging Het
Pclo A T 5: 14,589,422 (GRCm39) probably null Het
Pnpt1 T C 11: 29,088,174 (GRCm39) M195T probably benign Het
Polr3c T A 3: 96,633,170 (GRCm39) T43S probably damaging Het
Ptprs T C 17: 56,735,978 (GRCm39) T152A possibly damaging Het
Rasl10b A T 11: 83,309,349 (GRCm39) T134S probably benign Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Rnf39 T C 17: 37,258,121 (GRCm39) W96R probably damaging Het
Ros1 G T 10: 52,005,087 (GRCm39) A949E probably damaging Het
Rwdd2a A C 9: 86,456,214 (GRCm39) N130T possibly damaging Het
Scn9a T C 2: 66,313,992 (GRCm39) N1909D probably benign Het
Shisal1 A T 15: 84,290,886 (GRCm39) Y120* probably null Het
Ska3 C T 14: 58,047,534 (GRCm39) V334I probably benign Het
Srebf2 A G 15: 82,066,309 (GRCm39) K579R probably benign Het
Sun1 A G 5: 139,224,575 (GRCm39) probably benign Het
Tc2n T A 12: 101,660,833 (GRCm39) Q133L possibly damaging Het
Tecta T C 9: 42,242,292 (GRCm39) T2094A probably damaging Het
Tex2 T C 11: 106,437,720 (GRCm39) D650G unknown Het
Trio A G 15: 27,748,177 (GRCm39) S2492P probably damaging Het
Ttn T C 2: 76,601,711 (GRCm39) T16872A probably benign Het
Ugcg T C 4: 59,189,690 (GRCm39) F16S probably benign Het
Usp16 T C 16: 87,255,571 (GRCm39) M1T probably null Het
Vmn1r60 C A 7: 5,547,710 (GRCm39) C130F possibly damaging Het
Vmn2r101 A G 17: 19,809,919 (GRCm39) D235G probably benign Het
Vpreb3 A T 10: 75,775,800 (GRCm39) V26E probably benign Het
Vps39 C T 2: 120,172,497 (GRCm39) V179I possibly damaging Het
Xrn2 T C 2: 146,903,207 (GRCm39) V765A probably benign Het
Zfp426 A T 9: 20,384,413 (GRCm39) probably null Het
Zfp61 T C 7: 23,995,406 (GRCm39) M1V probably null Het
Other mutations in Zfp251
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01433:Zfp251 APN 15 76,738,755 (GRCm39) missense probably benign 0.33
IGL02868:Zfp251 APN 15 76,738,734 (GRCm39) missense probably damaging 1.00
R0011:Zfp251 UTSW 15 76,738,754 (GRCm39) missense probably benign 0.42
R0011:Zfp251 UTSW 15 76,738,754 (GRCm39) missense probably benign 0.42
R1199:Zfp251 UTSW 15 76,738,436 (GRCm39) missense possibly damaging 0.73
R1201:Zfp251 UTSW 15 76,738,436 (GRCm39) missense possibly damaging 0.73
R1321:Zfp251 UTSW 15 76,738,436 (GRCm39) missense possibly damaging 0.73
R1322:Zfp251 UTSW 15 76,738,436 (GRCm39) missense possibly damaging 0.73
R1565:Zfp251 UTSW 15 76,737,239 (GRCm39) missense possibly damaging 0.81
R1565:Zfp251 UTSW 15 76,737,238 (GRCm39) missense probably damaging 0.96
R1587:Zfp251 UTSW 15 76,754,484 (GRCm39) missense probably damaging 0.98
R1752:Zfp251 UTSW 15 76,737,863 (GRCm39) missense possibly damaging 0.71
R3772:Zfp251 UTSW 15 76,737,836 (GRCm39) missense possibly damaging 0.67
R3773:Zfp251 UTSW 15 76,737,836 (GRCm39) missense possibly damaging 0.67
R4684:Zfp251 UTSW 15 76,738,607 (GRCm39) missense possibly damaging 0.85
R5733:Zfp251 UTSW 15 76,754,527 (GRCm39) missense probably damaging 1.00
R6341:Zfp251 UTSW 15 76,738,337 (GRCm39) missense probably damaging 1.00
R7050:Zfp251 UTSW 15 76,738,496 (GRCm39) missense possibly damaging 0.53
R7605:Zfp251 UTSW 15 76,738,557 (GRCm39) missense possibly damaging 0.53
R8783:Zfp251 UTSW 15 76,737,413 (GRCm39) missense probably damaging 1.00
R9662:Zfp251 UTSW 15 76,737,520 (GRCm39) missense possibly damaging 0.53
Predicted Primers PCR Primer
(F):5'- ACACTCGTAAGGCTTCTCCC -3'
(R):5'- GTGGAAAGGCTTTCAGTCGG -3'

Sequencing Primer
(F):5'- TAAGGCTTCTCCCCGGTGTG -3'
(R):5'- GAACGCGAGCCTTATCCAG -3'
Posted On 2015-03-25