Incidental Mutation 'IGL00978:Ifne'
ID 27346
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifne
Ensembl Gene ENSMUSG00000045364
Gene Name interferon epsilon
Synonyms Ifnt1, Ifne1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00978
Quality Score
Status
Chromosome 4
Chromosomal Location 88879538-88880201 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88880031 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 50 (Q50R)
Ref Sequence ENSEMBL: ENSMUSP00000059199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056014]
AlphaFold Q80ZF2
Predicted Effect probably benign
Transcript: ENSMUST00000056014
AA Change: Q50R

PolyPhen 2 Score 0.170 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000059199
Gene: ENSMUSG00000045364
AA Change: Q50R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 37 51 N/A INTRINSIC
IFabd 58 175 2.09e-22 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to HSV-2 and Chlamydia infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610009L18Rik T C 11: 120,350,947 probably benign Het
Alpk2 A T 18: 65,291,534 probably benign Het
Angptl8 T C 9: 21,837,053 probably benign Het
AU040320 T A 4: 126,828,839 D383E probably benign Het
Cep97 C T 16: 55,924,960 probably benign Het
Clcn4 A T 7: 7,287,673 L649H probably damaging Het
Col5a2 T C 1: 45,376,739 N1416S probably benign Het
Erbb2 C T 11: 98,435,630 P1027S probably damaging Het
Eya1 A G 1: 14,270,701 probably benign Het
Gfm2 T C 13: 97,162,977 I402T probably benign Het
Gmeb2 A T 2: 181,259,043 V187E probably benign Het
Hectd1 T C 12: 51,791,390 H662R possibly damaging Het
Kidins220 A G 12: 25,057,474 D1642G probably damaging Het
Klhl32 T A 4: 24,682,245 D146V probably damaging Het
Krt36 T C 11: 100,102,948 I355V probably damaging Het
Lrrcc1 T A 3: 14,536,128 S73R possibly damaging Het
Ltbp3 A T 19: 5,754,019 H853L probably benign Het
Map3k5 G A 10: 20,141,567 R1369Q probably damaging Het
Mcm8 A G 2: 132,821,406 N148S probably benign Het
Mylk3 A T 8: 85,355,526 L211* probably null Het
Nras T C 3: 103,058,916 probably benign Het
Olfr135 A T 17: 38,208,982 I246F probably damaging Het
Olfr670 A T 7: 104,960,716 N5K probably damaging Het
Os9 A T 10: 127,120,509 Y66N probably damaging Het
Pitpnm1 A G 19: 4,101,228 D15G possibly damaging Het
Reg3a A T 6: 78,382,301 R95* probably null Het
Rnf17 C T 14: 56,512,271 P1425S probably damaging Het
Smad2 T C 18: 76,299,775 probably benign Het
Ttll5 C T 12: 85,933,482 Q76* probably null Het
Uri1 A T 7: 37,996,731 probably benign Het
Vmn2r102 G T 17: 19,678,923 probably null Het
Vmn2r70 T G 7: 85,563,799 M467L probably benign Het
Zfp318 T A 17: 46,413,726 D2218E possibly damaging Het
Zfp692 T C 11: 58,314,029 I405T possibly damaging Het
Zfp692 A G 11: 58,309,998 H235R possibly damaging Het
Other mutations in Ifne
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00594:Ifne APN 4 88879804 missense probably benign 0.01
IGL02167:Ifne APN 4 88879828 missense possibly damaging 0.58
R0212:Ifne UTSW 4 88879735 missense possibly damaging 0.95
R0699:Ifne UTSW 4 88879777 missense probably benign 0.00
R1868:Ifne UTSW 4 88879671 missense probably damaging 1.00
R4480:Ifne UTSW 4 88879601 makesense probably null
R4865:Ifne UTSW 4 88879705 missense probably damaging 1.00
R6752:Ifne UTSW 4 88880082 missense probably benign 0.06
R7319:Ifne UTSW 4 88880006 missense probably damaging 0.98
R7413:Ifne UTSW 4 88879603 makesense probably null
Posted On 2013-04-17