Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00978:Ifne'

27346

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifne

Ensembl Gene

ENSMUSG00000045364

Gene Name

interferon epsilon

Synonyms

Ifnt1, Ifne1

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00978

Quality Score

Status

Chromosome

Chromosomal Location

88879538-88880201 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88880031 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 50 (Q50R)

Ref Sequence

ENSEMBL: ENSMUSP00000059199 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056014]

Predicted Effect

probably benign
Transcript: ENSMUST00000056014
AA Change: Q50R

PolyPhen 2 Score 0.170 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000059199
Gene: ENSMUSG00000045364
AA Change: Q50R

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	37	51	N/A	INTRINSIC
IFabd	58	175	2.09e-22	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to HSV-2 and Chlamydia infection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009L18Rik	T	C	11: 120,350,947		probably benign	Het
Alpk2	A	T	18: 65,291,534		probably benign	Het
Angptl8	T	C	9: 21,837,053		probably benign	Het
AU040320	T	A	4: 126,828,839	D383E	probably benign	Het
Cep97	C	T	16: 55,924,960		probably benign	Het
Clcn4	A	T	7: 7,287,673	L649H	probably damaging	Het
Col5a2	T	C	1: 45,376,739	N1416S	probably benign	Het
Erbb2	C	T	11: 98,435,630	P1027S	probably damaging	Het
Eya1	A	G	1: 14,270,701		probably benign	Het
Gfm2	T	C	13: 97,162,977	I402T	probably benign	Het
Gmeb2	A	T	2: 181,259,043	V187E	probably benign	Het
Hectd1	T	C	12: 51,791,390	H662R	possibly damaging	Het
Kidins220	A	G	12: 25,057,474	D1642G	probably damaging	Het
Klhl32	T	A	4: 24,682,245	D146V	probably damaging	Het
Krt36	T	C	11: 100,102,948	I355V	probably damaging	Het
Lrrcc1	T	A	3: 14,536,128	S73R	possibly damaging	Het
Ltbp3	A	T	19: 5,754,019	H853L	probably benign	Het
Map3k5	G	A	10: 20,141,567	R1369Q	probably damaging	Het
Mcm8	A	G	2: 132,821,406	N148S	probably benign	Het
Mylk3	A	T	8: 85,355,526	L211*	probably null	Het
Nras	T	C	3: 103,058,916		probably benign	Het
Olfr135	A	T	17: 38,208,982	I246F	probably damaging	Het
Olfr670	A	T	7: 104,960,716	N5K	probably damaging	Het
Os9	A	T	10: 127,120,509	Y66N	probably damaging	Het
Pitpnm1	A	G	19: 4,101,228	D15G	possibly damaging	Het
Reg3a	A	T	6: 78,382,301	R95*	probably null	Het
Rnf17	C	T	14: 56,512,271	P1425S	probably damaging	Het
Smad2	T	C	18: 76,299,775		probably benign	Het
Ttll5	C	T	12: 85,933,482	Q76*	probably null	Het
Uri1	A	T	7: 37,996,731		probably benign	Het
Vmn2r102	G	T	17: 19,678,923		probably null	Het
Vmn2r70	T	G	7: 85,563,799	M467L	probably benign	Het
Zfp318	T	A	17: 46,413,726	D2218E	possibly damaging	Het
Zfp692	T	C	11: 58,314,029	I405T	possibly damaging	Het
Zfp692	A	G	11: 58,309,998	H235R	possibly damaging	Het

Other mutations in Ifne

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00594:Ifne	APN	4	88879804	missense	probably benign	0.01
IGL02167:Ifne	APN	4	88879828	missense	possibly damaging	0.58
R0212:Ifne	UTSW	4	88879735	missense	possibly damaging	0.95
R0699:Ifne	UTSW	4	88879777	missense	probably benign	0.00
R1868:Ifne	UTSW	4	88879671	missense	probably damaging	1.00
R4480:Ifne	UTSW	4	88879601	makesense	probably null
R4865:Ifne	UTSW	4	88879705	missense	probably damaging	1.00
R6752:Ifne	UTSW	4	88880082	missense	probably benign	0.06
R7319:Ifne	UTSW	4	88880006	missense	probably damaging	0.98
R7413:Ifne	UTSW	4	88879603	makesense	probably null

Posted On

2013-04-17