Incidental Mutation 'R3774:Wdr11'
ID 273507
Institutional Source Beutler Lab
Gene Symbol Wdr11
Ensembl Gene ENSMUSG00000042055
Gene Name WD repeat domain 11
Synonyms Wdr11, Brwd2, 2900055P10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.245) question?
Stock # R3774 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 129193587-129237462 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 129233417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000081567 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084519]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000084519
SMART Domains Protein: ENSMUSP00000081567
Gene: ENSMUSG00000042055

DomainStartEndE-ValueType
WD40 50 99 2e-1 SMART
WD40 102 145 2.84e2 SMART
low complexity region 189 200 N/A INTRINSIC
low complexity region 213 227 N/A INTRINSIC
low complexity region 454 465 N/A INTRINSIC
WD40 552 595 4.42e1 SMART
WD40 696 735 1.66e0 SMART
WD40 737 777 1.43e1 SMART
WD40 780 821 1.38e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136560
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140877
Predicted Effect probably benign
Transcript: ENSMUST00000148752
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149541
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadm A G 3: 153,638,734 (GRCm39) V213A probably benign Het
Ccndbp1 A G 2: 120,839,581 (GRCm39) K26R possibly damaging Het
Chrna10 T C 7: 101,763,535 (GRCm39) T87A probably benign Het
Col27a1 T A 4: 63,232,963 (GRCm39) N360K probably benign Het
Crispld2 T C 8: 120,756,005 (GRCm39) S325P probably damaging Het
Dgkd T A 1: 87,864,022 (GRCm39) I79N probably damaging Het
Dhdh T A 7: 45,131,362 (GRCm39) D157V probably benign Het
Dnajc15 A T 14: 78,094,377 (GRCm39) probably null Het
Fbxo44 G T 4: 148,241,051 (GRCm39) F179L probably damaging Het
Gm5565 T A 5: 146,095,419 (GRCm39) E192V probably benign Het
Gpat4 G A 8: 23,670,171 (GRCm39) P286L probably damaging Het
Itgav A G 2: 83,622,308 (GRCm39) E630G probably damaging Het
Iws1 T C 18: 32,213,048 (GRCm39) S159P probably damaging Het
Kif23 G A 9: 61,832,274 (GRCm39) S623L probably benign Het
Krt32 A G 11: 99,978,947 (GRCm39) C36R probably benign Het
Med12l A C 3: 59,155,363 (GRCm39) Q1181P probably damaging Het
Megf10 G A 18: 57,410,177 (GRCm39) G653S probably damaging Het
Mon1a A G 9: 107,778,502 (GRCm39) Y242C probably damaging Het
Msh6 G T 17: 88,293,609 (GRCm39) R788L probably damaging Het
Mttp T C 3: 137,820,024 (GRCm39) probably null Het
Mxi1 C A 19: 53,360,160 (GRCm39) A294E probably benign Het
Olfm5 T A 7: 103,811,056 (GRCm39) R27S possibly damaging Het
Or52n2b T A 7: 104,566,113 (GRCm39) Y130F probably benign Het
Palmd T C 3: 116,721,312 (GRCm39) E81G probably damaging Het
Pecr A G 1: 72,298,530 (GRCm39) F297L probably benign Het
Phf11b A G 14: 59,563,506 (GRCm39) L137S probably benign Het
Phlpp1 GAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC GAGCAGCAGCAGCAGCAGCAGCAGCAGC 1: 106,320,921 (GRCm39) probably benign Het
Plcb4 A G 2: 135,800,065 (GRCm39) K472E probably benign Het
Pomgnt1 G A 4: 116,011,325 (GRCm39) R230H probably damaging Het
Pomt1 A G 2: 32,134,262 (GRCm39) H261R possibly damaging Het
Ppm1d T C 11: 85,227,993 (GRCm39) I303T probably damaging Het
Ptprc T G 1: 137,992,511 (GRCm39) Q1205H probably damaging Het
Rad23b C T 4: 55,382,589 (GRCm39) T264I possibly damaging Het
Rfc1 T C 5: 65,421,749 (GRCm39) Y1050C probably damaging Het
Septin8 T C 11: 53,428,406 (GRCm39) V352A probably damaging Het
Slc25a13 T A 6: 6,109,288 (GRCm39) Q358L probably damaging Het
Ssh1 T C 5: 114,104,783 (GRCm39) D12G probably damaging Het
Tmem59l A G 8: 70,939,951 (GRCm39) L6S unknown Het
Tnik T C 3: 28,692,568 (GRCm39) Y820H probably damaging Het
Trpm3 T C 19: 22,955,966 (GRCm39) F1143L possibly damaging Het
Trpm3 T A 19: 22,965,339 (GRCm39) S1611R probably benign Het
Ttyh3 A G 5: 140,634,489 (GRCm39) F32L probably damaging Het
Unkl T A 17: 25,407,381 (GRCm39) probably null Het
Vwf T A 6: 125,626,062 (GRCm39) probably null Het
Yeats2 A G 16: 19,969,245 (GRCm39) D12G probably damaging Het
Other mutations in Wdr11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Wdr11 APN 7 129,194,817 (GRCm39) splice site probably null
IGL01121:Wdr11 APN 7 129,229,746 (GRCm39) missense probably benign 0.02
IGL01385:Wdr11 APN 7 129,209,637 (GRCm39) missense probably benign
IGL01923:Wdr11 APN 7 129,234,046 (GRCm39) critical splice acceptor site probably null
IGL02274:Wdr11 APN 7 129,232,896 (GRCm39) critical splice acceptor site probably null
IGL02894:Wdr11 APN 7 129,232,890 (GRCm39) splice site probably benign
IGL02927:Wdr11 APN 7 129,208,822 (GRCm39) critical splice donor site probably null
IGL03008:Wdr11 APN 7 129,208,715 (GRCm39) unclassified probably benign
IGL03026:Wdr11 APN 7 129,226,060 (GRCm39) missense probably damaging 1.00
IGL03354:Wdr11 APN 7 129,227,026 (GRCm39) missense probably benign 0.01
IGL03379:Wdr11 APN 7 129,200,847 (GRCm39) missense probably damaging 1.00
beeline UTSW 7 129,207,437 (GRCm39) nonsense probably null
bekummernis UTSW 7 129,226,451 (GRCm39) missense probably damaging 0.97
hort UTSW 7 129,232,523 (GRCm39) critical splice donor site probably null
Knees UTSW 7 129,236,560 (GRCm39) missense probably benign 0.02
Propeller UTSW 7 129,208,399 (GRCm39) missense possibly damaging 0.91
Zuversicht UTSW 7 129,208,264 (GRCm39) missense probably benign 0.13
R0003:Wdr11 UTSW 7 129,200,785 (GRCm39) missense probably damaging 1.00
R0928:Wdr11 UTSW 7 129,208,377 (GRCm39) missense probably damaging 1.00
R1170:Wdr11 UTSW 7 129,208,831 (GRCm39) unclassified probably benign
R1645:Wdr11 UTSW 7 129,215,613 (GRCm39) missense probably benign 0.29
R1908:Wdr11 UTSW 7 129,206,954 (GRCm39) missense possibly damaging 0.60
R1938:Wdr11 UTSW 7 129,208,331 (GRCm39) missense probably benign 0.08
R2122:Wdr11 UTSW 7 129,233,490 (GRCm39) missense probably damaging 1.00
R2148:Wdr11 UTSW 7 129,230,807 (GRCm39) splice site probably null
R2240:Wdr11 UTSW 7 129,207,418 (GRCm39) critical splice acceptor site probably null
R2362:Wdr11 UTSW 7 129,236,560 (GRCm39) missense probably benign 0.05
R4297:Wdr11 UTSW 7 129,226,910 (GRCm39) missense probably benign 0.18
R4546:Wdr11 UTSW 7 129,230,729 (GRCm39) missense probably damaging 1.00
R4787:Wdr11 UTSW 7 129,210,658 (GRCm39) splice site probably benign
R4789:Wdr11 UTSW 7 129,220,394 (GRCm39) nonsense probably null
R4807:Wdr11 UTSW 7 129,229,746 (GRCm39) missense probably benign 0.02
R4855:Wdr11 UTSW 7 129,202,158 (GRCm39) splice site probably null
R4898:Wdr11 UTSW 7 129,235,445 (GRCm39) missense probably benign
R5022:Wdr11 UTSW 7 129,226,435 (GRCm39) missense probably benign 0.10
R5326:Wdr11 UTSW 7 129,226,973 (GRCm39) missense probably damaging 1.00
R5398:Wdr11 UTSW 7 129,232,956 (GRCm39) missense probably damaging 1.00
R6120:Wdr11 UTSW 7 129,226,515 (GRCm39) missense probably damaging 0.99
R6136:Wdr11 UTSW 7 129,220,427 (GRCm39) missense possibly damaging 0.86
R6280:Wdr11 UTSW 7 129,200,830 (GRCm39) nonsense probably null
R6352:Wdr11 UTSW 7 129,208,399 (GRCm39) missense possibly damaging 0.91
R6432:Wdr11 UTSW 7 129,208,242 (GRCm39) missense possibly damaging 0.83
R6766:Wdr11 UTSW 7 129,226,036 (GRCm39) missense probably benign 0.02
R6911:Wdr11 UTSW 7 129,208,819 (GRCm39) missense probably benign 0.28
R7135:Wdr11 UTSW 7 129,229,830 (GRCm39) missense possibly damaging 0.76
R7151:Wdr11 UTSW 7 129,208,376 (GRCm39) missense probably damaging 1.00
R7463:Wdr11 UTSW 7 129,208,810 (GRCm39) missense probably damaging 0.99
R7503:Wdr11 UTSW 7 129,204,834 (GRCm39) missense probably benign
R8097:Wdr11 UTSW 7 129,209,611 (GRCm39) missense probably damaging 1.00
R8254:Wdr11 UTSW 7 129,236,560 (GRCm39) missense probably benign 0.02
R8354:Wdr11 UTSW 7 129,204,723 (GRCm39) missense probably damaging 0.99
R8377:Wdr11 UTSW 7 129,208,412 (GRCm39) missense possibly damaging 0.56
R8416:Wdr11 UTSW 7 129,232,403 (GRCm39) missense possibly damaging 0.62
R8708:Wdr11 UTSW 7 129,200,780 (GRCm39) missense probably benign 0.07
R8896:Wdr11 UTSW 7 129,207,437 (GRCm39) nonsense probably null
R9092:Wdr11 UTSW 7 129,226,451 (GRCm39) missense probably damaging 0.97
R9136:Wdr11 UTSW 7 129,204,816 (GRCm39) missense
R9315:Wdr11 UTSW 7 129,208,264 (GRCm39) missense probably benign 0.13
R9343:Wdr11 UTSW 7 129,232,523 (GRCm39) critical splice donor site probably null
R9663:Wdr11 UTSW 7 129,210,647 (GRCm39) missense probably damaging 1.00
R9771:Wdr11 UTSW 7 129,206,851 (GRCm39) missense probably damaging 1.00
Z1177:Wdr11 UTSW 7 129,209,602 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTGCCTTAGAGATGAAGTGC -3'
(R):5'- CATGTCTCTAACTGCCCAGC -3'

Sequencing Primer
(F):5'- TGAAGTGCAGGCGGTACTG -3'
(R):5'- GCAGTCAAAGTGCCTTACCTG -3'
Posted On 2015-03-25