Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00904:Gm6583'

27385

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm6583

Ensembl Gene

ENSMUSG00000051503

Gene Name

predicted gene 6583

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL00904

Quality Score

Status

Chromosome

Chromosomal Location

112353801-112356033 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 112355128 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 237 (R237*)

Ref Sequence

ENSEMBL: ENSMUSP00000049839 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035279] [ENSMUST00000051117] [ENSMUST00000112359]

Predicted Effect

probably benign
Transcript: ENSMUST00000035279

SMART Domains

Protein: ENSMUSP00000047920
Gene: ENSMUSG00000042328

Domain	Start	End	E-Value	Type
low complexity region	171	180	N/A	INTRINSIC
low complexity region	467	486	N/A	INTRINSIC
low complexity region	514	529	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000051117
AA Change: R237*

SMART Domains

Protein: ENSMUSP00000049839
Gene: ENSMUSG00000051503
AA Change: R237*

Domain	Start	End	E-Value	Type
low complexity region	71	83	N/A	INTRINSIC
coiled coil region	159	193	N/A	INTRINSIC
Pfam:DUF4515	199	404	1.2e-79	PFAM
low complexity region	406	422	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000112359

SMART Domains

Protein: ENSMUSP00000107978
Gene: ENSMUSG00000042328

Domain	Start	End	E-Value	Type
low complexity region	171	180	N/A	INTRINSIC
low complexity region	467	486	N/A	INTRINSIC
low complexity region	514	529	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133708

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aak1	G	T	6: 86,946,153	G236C	probably damaging	Het
Abi1	C	T	2: 22,941,930	R404Q	possibly damaging	Het
Atp8b3	C	T	10: 80,528,764	G532R	probably damaging	Het
Bysl	C	T	17: 47,601,871	M331I	probably benign	Het
Cndp1	A	G	18: 84,611,665	S468P	probably benign	Het
Esd	A	G	14: 74,749,688	*266W	probably null	Het
F5	T	C	1: 164,194,009	V1351A	probably benign	Het
Fchsd2	A	G	7: 101,271,622	D454G	probably benign	Het
Fndc1	T	A	17: 7,756,363	M1415L	probably benign	Het
Ghr	T	A	15: 3,328,120	Y222F	probably benign	Het
Gtf3c2	C	T	5: 31,172,858	S299N	probably damaging	Het
Ice1	C	T	13: 70,602,289	D93N	probably damaging	Het
Ints7	T	A	1: 191,596,164		probably null	Het
Kif18a	A	G	2: 109,292,126	D182G	probably damaging	Het
Mcm9	A	T	10: 53,622,921	H308Q	possibly damaging	Het
Mesp2	A	G	7: 79,812,653	D319G	probably benign	Het
Mrpl55	T	A	11: 59,205,673	S84T	probably benign	Het
Mybpc3	T	C	2: 91,120,029	V123A	probably benign	Het
Myom1	T	C	17: 71,099,949		probably benign	Het
Nfia	C	T	4: 98,065,386	P325S	probably damaging	Het
Notch4	T	C	17: 34,575,561		probably null	Het
Npepps	A	C	11: 97,258,306	V130G	probably damaging	Het
Olfr1356	A	T	10: 78,847,763	S51T	probably damaging	Het
Pja2	G	T	17: 64,283,531	T669K	probably damaging	Het
Rnf112	G	T	11: 61,452,784	D98E	probably damaging	Het
Rsl1d1	G	A	16: 11,199,694	T136I	probably damaging	Het
Samsn1	A	T	16: 75,909,120		probably benign	Het
Slc6a9	T	C	4: 117,864,617	L280P	probably damaging	Het
Svep1	T	C	4: 58,097,398	N1382D	probably benign	Het
Vmn2r100	T	G	17: 19,526,000	C474G	probably damaging	Het
Vmn2r74	C	T	7: 85,957,580	R186H	probably benign	Het
Wdr7	T	C	18: 63,796,231	I1046T	probably benign	Het

Other mutations in Gm6583

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01464:Gm6583	APN	5	112355533	missense	possibly damaging	0.93
IGL01615:Gm6583	APN	5	112355830	missense	possibly damaging	0.93
R0508:Gm6583	UTSW	5	112354819	missense	probably damaging	0.99
R1466:Gm6583	UTSW	5	112354764	missense	probably benign	0.00
R1466:Gm6583	UTSW	5	112354764	missense	probably benign	0.00
R1473:Gm6583	UTSW	5	112354549	missense	probably benign	0.45
R1474:Gm6583	UTSW	5	112355776	missense	probably benign
R1584:Gm6583	UTSW	5	112354764	missense	probably benign	0.00
R2032:Gm6583	UTSW	5	112355112	missense	possibly damaging	0.95
R2422:Gm6583	UTSW	5	112355118	missense	probably damaging	1.00
R4795:Gm6583	UTSW	5	112355299	missense	possibly damaging	0.65
R4796:Gm6583	UTSW	5	112355299	missense	possibly damaging	0.65
R5306:Gm6583	UTSW	5	112355044	missense	probably benign	0.41
R5997:Gm6583	UTSW	5	112355008	missense	possibly damaging	0.71
R6915:Gm6583	UTSW	5	112354657	missense	probably damaging	1.00
R7022:Gm6583	UTSW	5	112355529	missense	probably benign
R7702:Gm6583	UTSW	5	112355197	missense	probably benign	0.27
R7721:Gm6583	UTSW	5	112355517	missense	probably benign
R8037:Gm6583	UTSW	5	112355016	missense	probably benign	0.23
R8114:Gm6583	UTSW	5	112355697	missense	probably benign
R8380:Gm6583	UTSW	5	112355325	missense	probably benign	0.01
Z1177:Gm6583	UTSW	5	112354918	missense	probably damaging	0.98

Posted On

2013-04-17