Incidental Mutation 'IGL00904:Gm6583'
ID27385
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm6583
Ensembl Gene ENSMUSG00000051503
Gene Namepredicted gene 6583
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL00904
Quality Score
Status
Chromosome5
Chromosomal Location112353801-112356033 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 112355128 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 237 (R237*)
Ref Sequence ENSEMBL: ENSMUSP00000049839 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035279] [ENSMUST00000051117] [ENSMUST00000112359]
Predicted Effect probably benign
Transcript: ENSMUST00000035279
SMART Domains Protein: ENSMUSP00000047920
Gene: ENSMUSG00000042328

DomainStartEndE-ValueType
low complexity region 171 180 N/A INTRINSIC
low complexity region 467 486 N/A INTRINSIC
low complexity region 514 529 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000051117
AA Change: R237*
SMART Domains Protein: ENSMUSP00000049839
Gene: ENSMUSG00000051503
AA Change: R237*

DomainStartEndE-ValueType
low complexity region 71 83 N/A INTRINSIC
coiled coil region 159 193 N/A INTRINSIC
Pfam:DUF4515 199 404 1.2e-79 PFAM
low complexity region 406 422 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112359
SMART Domains Protein: ENSMUSP00000107978
Gene: ENSMUSG00000042328

DomainStartEndE-ValueType
low complexity region 171 180 N/A INTRINSIC
low complexity region 467 486 N/A INTRINSIC
low complexity region 514 529 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133708
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 G T 6: 86,946,153 G236C probably damaging Het
Abi1 C T 2: 22,941,930 R404Q possibly damaging Het
Atp8b3 C T 10: 80,528,764 G532R probably damaging Het
Bysl C T 17: 47,601,871 M331I probably benign Het
Cndp1 A G 18: 84,611,665 S468P probably benign Het
Esd A G 14: 74,749,688 *266W probably null Het
F5 T C 1: 164,194,009 V1351A probably benign Het
Fchsd2 A G 7: 101,271,622 D454G probably benign Het
Fndc1 T A 17: 7,756,363 M1415L probably benign Het
Ghr T A 15: 3,328,120 Y222F probably benign Het
Gtf3c2 C T 5: 31,172,858 S299N probably damaging Het
Ice1 C T 13: 70,602,289 D93N probably damaging Het
Ints7 T A 1: 191,596,164 probably null Het
Kif18a A G 2: 109,292,126 D182G probably damaging Het
Mcm9 A T 10: 53,622,921 H308Q possibly damaging Het
Mesp2 A G 7: 79,812,653 D319G probably benign Het
Mrpl55 T A 11: 59,205,673 S84T probably benign Het
Mybpc3 T C 2: 91,120,029 V123A probably benign Het
Myom1 T C 17: 71,099,949 probably benign Het
Nfia C T 4: 98,065,386 P325S probably damaging Het
Notch4 T C 17: 34,575,561 probably null Het
Npepps A C 11: 97,258,306 V130G probably damaging Het
Olfr1356 A T 10: 78,847,763 S51T probably damaging Het
Pja2 G T 17: 64,283,531 T669K probably damaging Het
Rnf112 G T 11: 61,452,784 D98E probably damaging Het
Rsl1d1 G A 16: 11,199,694 T136I probably damaging Het
Samsn1 A T 16: 75,909,120 probably benign Het
Slc6a9 T C 4: 117,864,617 L280P probably damaging Het
Svep1 T C 4: 58,097,398 N1382D probably benign Het
Vmn2r100 T G 17: 19,526,000 C474G probably damaging Het
Vmn2r74 C T 7: 85,957,580 R186H probably benign Het
Wdr7 T C 18: 63,796,231 I1046T probably benign Het
Other mutations in Gm6583
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01464:Gm6583 APN 5 112355533 missense possibly damaging 0.93
IGL01615:Gm6583 APN 5 112355830 missense possibly damaging 0.93
R0508:Gm6583 UTSW 5 112354819 missense probably damaging 0.99
R1466:Gm6583 UTSW 5 112354764 missense probably benign 0.00
R1466:Gm6583 UTSW 5 112354764 missense probably benign 0.00
R1473:Gm6583 UTSW 5 112354549 missense probably benign 0.45
R1474:Gm6583 UTSW 5 112355776 missense probably benign
R1584:Gm6583 UTSW 5 112354764 missense probably benign 0.00
R2032:Gm6583 UTSW 5 112355112 missense possibly damaging 0.95
R2422:Gm6583 UTSW 5 112355118 missense probably damaging 1.00
R4795:Gm6583 UTSW 5 112355299 missense possibly damaging 0.65
R4796:Gm6583 UTSW 5 112355299 missense possibly damaging 0.65
R5306:Gm6583 UTSW 5 112355044 missense probably benign 0.41
R5997:Gm6583 UTSW 5 112355008 missense possibly damaging 0.71
R6915:Gm6583 UTSW 5 112354657 missense probably damaging 1.00
R7022:Gm6583 UTSW 5 112355529 missense probably benign
R7702:Gm6583 UTSW 5 112355197 missense probably benign 0.27
R7721:Gm6583 UTSW 5 112355517 missense probably benign
R8037:Gm6583 UTSW 5 112355016 missense probably benign 0.23
R8114:Gm6583 UTSW 5 112355697 missense probably benign
R8380:Gm6583 UTSW 5 112355325 missense probably benign 0.01
Z1177:Gm6583 UTSW 5 112354918 missense probably damaging 0.98
Posted On2013-04-17