Incidental Mutation 'R3828:Gm17521'
ID 273868
Institutional Source Beutler Lab
Gene Symbol Gm17521
Ensembl Gene ENSMUSG00000094864
Gene Name predicted gene, 17521
MMRRC Submission 040886-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.432) question?
Stock # R3828 (G1)
Quality Score 222
Status Validated
Chromosome X
Chromosomal Location 123029202-123029669 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 123029225 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glycine to Cysteine at position 149 (G149C)
Ref Sequence ENSEMBL: ENSMUSP00000130606 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165345]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000165345
AA Change: G149C
SMART Domains Protein: ENSMUSP00000130606
Gene: ENSMUSG00000094864
AA Change: G149C

low complexity region 117 123 N/A INTRINSIC
low complexity region 144 155 N/A INTRINSIC
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (34/34)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Camk2b A G 11: 6,028,932 V32A probably damaging Het
Cbr2 A T 11: 120,730,452 H140Q probably benign Het
Cdk19 T C 10: 40,475,613 V258A probably damaging Het
Cep104 T G 4: 153,984,943 M207R probably damaging Het
Chd2 A G 7: 73,491,415 Y577H possibly damaging Het
Col4a1 C A 8: 11,209,650 G1341V probably damaging Het
Commd9 C A 2: 101,897,141 N93K probably benign Het
Cx3cl1 A T 8: 94,777,306 probably benign Het
Cxcr6 A T 9: 123,810,869 M319L probably benign Het
Dlg5 T A 14: 24,146,158 K1308I probably damaging Het
Dnah17 G A 11: 118,041,158 probably benign Het
Ffar2 A T 7: 30,820,085 I10N possibly damaging Het
Gm5862 T G 5: 26,019,347 H208P probably benign Het
Gpat4 G A 8: 23,180,155 P286L probably damaging Het
Ino80d A T 1: 63,062,078 M463K possibly damaging Het
Lrp2 G A 2: 69,426,012 P4595S probably benign Het
Mark4 A G 7: 19,443,187 I239T possibly damaging Het
Mcoln1 C T 8: 3,500,601 A2V possibly damaging Het
Mcts1 T C X: 38,602,568 probably benign Het
Mrgprb5 T A 7: 48,168,091 M299L probably benign Het
Ncapg2 A T 12: 116,407,318 probably benign Het
Olfr679 A G 7: 105,086,297 N194D probably benign Het
Pcdhga4 G T 18: 37,687,601 L734F possibly damaging Het
Rrm2 G T 12: 24,708,599 A47S probably benign Het
Rsg1 C T 4: 141,218,589 R148C probably damaging Het
Rsph6a T C 7: 19,057,614 L236P probably damaging Het
Rtkn2 A T 10: 67,997,626 probably null Het
Stk11 T C 10: 80,127,948 probably null Het
Syt14 T C 1: 192,901,775 N444S probably damaging Het
Tmem59l A G 8: 70,487,301 L6S unknown Het
Tnks A G 8: 34,873,178 F429L probably damaging Het
Usp15 T A 10: 123,196,870 I16F possibly damaging Het
Vps50 T C 6: 3,533,500 I244T probably benign Het
Other mutations in Gm17521
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0026:Gm17521 UTSW X 123029542 missense probably benign 0.01
R3827:Gm17521 UTSW X 123029225 missense unknown
R3829:Gm17521 UTSW X 123029225 missense unknown
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-04-02