Incidental Mutation 'R3832:Vmn2r17'
ID 274049
Institutional Source Beutler Lab
Gene Symbol Vmn2r17
Ensembl Gene ENSMUSG00000091879
Gene Name vomeronasal 2, receptor 17
Synonyms EG384221
MMRRC Submission 040887-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R3832 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 109567879-109601253 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 109576262 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 378 (W378R)
Ref Sequence ENSEMBL: ENSMUSP00000131450 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171841]
AlphaFold E9PYF5
Predicted Effect probably damaging
Transcript: ENSMUST00000171841
AA Change: W378R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: W378R

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 76 465 7e-26 PFAM
Pfam:NCD3G 508 562 3.5e-18 PFAM
Pfam:7tm_3 593 830 4.8e-55 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 A C 15: 94,229,339 (GRCm39) C927G probably damaging Het
Afdn T A 17: 14,116,436 (GRCm39) D190E probably benign Het
Aldh1a7 T C 19: 20,685,602 (GRCm39) Y316C probably damaging Het
Arhgef38 T C 3: 132,912,686 (GRCm39) R118G possibly damaging Het
Bcar3 A G 3: 122,220,298 (GRCm39) D65G probably damaging Het
Cacna1i T C 15: 80,240,388 (GRCm39) F370S probably damaging Het
Cacnb2 A T 2: 14,986,236 (GRCm39) I338F probably damaging Het
Cblc T C 7: 19,526,097 (GRCm39) M238V probably damaging Het
Ccdc3 A G 2: 5,233,953 (GRCm39) N259S probably benign Het
Cep55 A G 19: 38,041,560 (GRCm39) probably benign Het
Col6a1 T C 10: 76,546,951 (GRCm39) D757G unknown Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,604,632 (GRCm39) probably null Het
Cyb5d2 G T 11: 72,686,349 (GRCm39) S80R possibly damaging Het
Cyfip2 T C 11: 46,152,333 (GRCm39) D485G probably benign Het
Cyp27b1 G T 10: 126,886,929 (GRCm39) V382L probably damaging Het
Erich3 G A 3: 154,467,998 (GRCm39) V817M probably damaging Het
Gdf6 T C 4: 9,844,568 (GRCm39) S31P probably benign Het
Gtsf1 T C 15: 103,333,902 (GRCm39) I25V probably damaging Het
Hephl1 T C 9: 14,981,044 (GRCm39) E796G probably damaging Het
Iglv2 A T 16: 19,079,593 (GRCm39) M1K probably null Het
Kif26b GAAA GAA 1: 178,744,181 (GRCm39) probably null Het
Klhl28 C A 12: 64,998,195 (GRCm39) G433V probably damaging Het
Lipn T C 19: 34,046,933 (GRCm39) probably null Het
Lypd10 T A 7: 24,413,712 (GRCm39) S243T probably benign Het
Mapk7 A G 11: 61,380,680 (GRCm39) S641P possibly damaging Het
Med22 A G 2: 26,800,379 (GRCm39) S17P probably damaging Het
Or14c44 A T 7: 86,062,401 (GRCm39) Y277F probably damaging Het
Or14j5 T C 17: 38,162,071 (GRCm39) V196A probably benign Het
Otud1 G C 2: 19,662,951 (GRCm39) A27P possibly damaging Het
Pcdhga6 A T 18: 37,841,479 (GRCm39) N400Y probably damaging Het
Pdgfd T C 9: 6,359,762 (GRCm39) S278P probably damaging Het
Pdzd7 A T 19: 45,028,693 (GRCm39) V150E probably damaging Het
Peak1 T C 9: 56,165,667 (GRCm39) S754G probably benign Het
Phf14 A G 6: 11,933,873 (GRCm39) probably null Het
Phlpp1 G A 1: 106,320,327 (GRCm39) E1441K probably damaging Het
Piezo2 A G 18: 63,214,733 (GRCm39) probably null Het
Pikfyve G A 1: 65,283,579 (GRCm39) V739I probably damaging Het
Plcg1 T G 2: 160,596,357 (GRCm39) M651R possibly damaging Het
Prex2 T C 1: 11,226,588 (GRCm39) probably benign Het
Pus3 G C 9: 35,477,874 (GRCm39) G369R probably benign Het
Rab11fip1 G A 8: 27,642,774 (GRCm39) T675I probably benign Het
Scarf1 T C 11: 75,406,078 (GRCm39) C121R probably damaging Het
Sco1 T C 11: 66,944,605 (GRCm39) V76A probably damaging Het
Slc39a8 T A 3: 135,554,894 (GRCm39) C113S probably damaging Het
Slit3 A T 11: 35,579,509 (GRCm39) S1229C probably null Het
Snd1 G T 6: 28,531,403 (GRCm39) probably benign Het
Tbc1d9 A G 8: 83,960,292 (GRCm39) S182G probably damaging Het
Tecta A C 9: 42,250,329 (GRCm39) F1816C probably damaging Het
Tekt1 T C 11: 72,245,645 (GRCm39) N170S probably benign Het
Trim47 T C 11: 115,998,783 (GRCm39) T279A probably benign Het
Ttll4 A G 1: 74,725,550 (GRCm39) K653E probably damaging Het
Vcam1 T C 3: 115,908,140 (GRCm39) T641A possibly damaging Het
Vmn1r16 A G 6: 57,300,212 (GRCm39) F137L probably benign Het
Zfp777 T C 6: 48,021,149 (GRCm39) T158A probably benign Het
Zp1 T C 19: 10,893,888 (GRCm39) D439G probably damaging Het
Other mutations in Vmn2r17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Vmn2r17 APN 5 109,575,858 (GRCm39) missense probably benign 0.15
IGL01457:Vmn2r17 APN 5 109,600,898 (GRCm39) missense probably benign 0.00
IGL01527:Vmn2r17 APN 5 109,601,006 (GRCm39) missense probably damaging 1.00
IGL01693:Vmn2r17 APN 5 109,600,384 (GRCm39) missense probably damaging 1.00
IGL01738:Vmn2r17 APN 5 109,577,364 (GRCm39) missense probably damaging 1.00
IGL01767:Vmn2r17 APN 5 109,567,903 (GRCm39) missense probably benign 0.01
IGL01932:Vmn2r17 APN 5 109,574,916 (GRCm39) missense probably benign 0.00
IGL01970:Vmn2r17 APN 5 109,575,813 (GRCm39) missense probably damaging 0.97
IGL02009:Vmn2r17 APN 5 109,600,714 (GRCm39) missense possibly damaging 0.67
IGL02365:Vmn2r17 APN 5 109,601,175 (GRCm39) missense probably damaging 1.00
IGL02385:Vmn2r17 APN 5 109,582,247 (GRCm39) missense probably damaging 1.00
IGL02457:Vmn2r17 APN 5 109,601,012 (GRCm39) missense probably damaging 1.00
IGL02646:Vmn2r17 APN 5 109,600,946 (GRCm39) missense probably damaging 1.00
IGL02741:Vmn2r17 APN 5 109,568,077 (GRCm39) missense probably benign
IGL03213:Vmn2r17 APN 5 109,582,256 (GRCm39) critical splice donor site probably null
IGL03216:Vmn2r17 APN 5 109,600,756 (GRCm39) missense probably damaging 1.00
IGL03342:Vmn2r17 APN 5 109,575,782 (GRCm39) missense probably damaging 1.00
IGL03408:Vmn2r17 APN 5 109,577,238 (GRCm39) splice site probably benign
R0349:Vmn2r17 UTSW 5 109,576,202 (GRCm39) missense probably damaging 1.00
R0418:Vmn2r17 UTSW 5 109,600,747 (GRCm39) missense probably damaging 1.00
R0800:Vmn2r17 UTSW 5 109,575,192 (GRCm39) splice site probably benign
R0836:Vmn2r17 UTSW 5 109,575,822 (GRCm39) missense possibly damaging 0.89
R1715:Vmn2r17 UTSW 5 109,576,110 (GRCm39) missense probably benign 0.00
R1738:Vmn2r17 UTSW 5 109,576,377 (GRCm39) missense probably benign 0.10
R1801:Vmn2r17 UTSW 5 109,576,344 (GRCm39) missense probably damaging 1.00
R2054:Vmn2r17 UTSW 5 109,600,352 (GRCm39) missense probably damaging 0.98
R2060:Vmn2r17 UTSW 5 109,575,075 (GRCm39) missense probably benign 0.00
R2192:Vmn2r17 UTSW 5 109,582,144 (GRCm39) missense possibly damaging 0.81
R2315:Vmn2r17 UTSW 5 109,575,897 (GRCm39) missense probably damaging 1.00
R2374:Vmn2r17 UTSW 5 109,575,104 (GRCm39) missense probably benign
R3612:Vmn2r17 UTSW 5 109,577,463 (GRCm39) missense probably benign 0.00
R4273:Vmn2r17 UTSW 5 109,600,832 (GRCm39) missense probably benign 0.44
R4494:Vmn2r17 UTSW 5 109,576,335 (GRCm39) missense probably damaging 1.00
R4597:Vmn2r17 UTSW 5 109,577,428 (GRCm39) missense probably benign 0.01
R4675:Vmn2r17 UTSW 5 109,575,049 (GRCm39) missense probably benign 0.00
R4701:Vmn2r17 UTSW 5 109,575,849 (GRCm39) missense probably damaging 0.99
R4754:Vmn2r17 UTSW 5 109,600,715 (GRCm39) missense probably damaging 0.99
R4841:Vmn2r17 UTSW 5 109,582,246 (GRCm39) missense probably damaging 1.00
R4842:Vmn2r17 UTSW 5 109,582,246 (GRCm39) missense probably damaging 1.00
R4865:Vmn2r17 UTSW 5 109,574,985 (GRCm39) missense probably damaging 1.00
R4902:Vmn2r17 UTSW 5 109,601,220 (GRCm39) missense probably benign 0.14
R4989:Vmn2r17 UTSW 5 109,575,739 (GRCm39) missense probably benign 0.07
R5101:Vmn2r17 UTSW 5 109,576,217 (GRCm39) missense probably damaging 0.99
R5109:Vmn2r17 UTSW 5 109,577,342 (GRCm39) missense probably benign 0.06
R5123:Vmn2r17 UTSW 5 109,575,774 (GRCm39) missense possibly damaging 0.90
R5474:Vmn2r17 UTSW 5 109,582,150 (GRCm39) missense probably damaging 1.00
R5485:Vmn2r17 UTSW 5 109,567,972 (GRCm39) missense probably benign 0.06
R5611:Vmn2r17 UTSW 5 109,576,030 (GRCm39) missense probably damaging 0.97
R5652:Vmn2r17 UTSW 5 109,577,430 (GRCm39) missense probably benign 0.10
R5717:Vmn2r17 UTSW 5 109,575,140 (GRCm39) missense possibly damaging 0.94
R5735:Vmn2r17 UTSW 5 109,600,716 (GRCm39) missense possibly damaging 0.67
R5766:Vmn2r17 UTSW 5 109,575,139 (GRCm39) missense possibly damaging 0.46
R6645:Vmn2r17 UTSW 5 109,576,247 (GRCm39) missense probably damaging 1.00
R6786:Vmn2r17 UTSW 5 109,575,695 (GRCm39) missense probably benign 0.30
R6821:Vmn2r17 UTSW 5 109,577,331 (GRCm39) missense probably damaging 1.00
R6979:Vmn2r17 UTSW 5 109,576,265 (GRCm39) missense possibly damaging 0.46
R6984:Vmn2r17 UTSW 5 109,600,533 (GRCm39) missense probably benign 0.10
R7269:Vmn2r17 UTSW 5 109,576,337 (GRCm39) missense possibly damaging 0.88
R7509:Vmn2r17 UTSW 5 109,575,695 (GRCm39) missense probably benign 0.30
R7736:Vmn2r17 UTSW 5 109,600,757 (GRCm39) missense probably benign 0.05
R7789:Vmn2r17 UTSW 5 109,600,831 (GRCm39) missense possibly damaging 0.77
R7814:Vmn2r17 UTSW 5 109,575,739 (GRCm39) missense probably benign 0.07
R7847:Vmn2r17 UTSW 5 109,568,063 (GRCm39) missense probably damaging 1.00
R7863:Vmn2r17 UTSW 5 109,568,035 (GRCm39) missense probably benign
R7893:Vmn2r17 UTSW 5 109,575,944 (GRCm39) missense probably benign 0.05
R8234:Vmn2r17 UTSW 5 109,601,235 (GRCm39) missense probably benign 0.01
R8382:Vmn2r17 UTSW 5 109,576,387 (GRCm39) missense probably benign 0.01
R8435:Vmn2r17 UTSW 5 109,576,172 (GRCm39) missense probably benign 0.01
R8465:Vmn2r17 UTSW 5 109,600,691 (GRCm39) missense probably damaging 0.99
R8555:Vmn2r17 UTSW 5 109,600,810 (GRCm39) missense probably damaging 0.99
R8900:Vmn2r17 UTSW 5 109,575,863 (GRCm39) missense probably benign 0.25
R9293:Vmn2r17 UTSW 5 109,600,712 (GRCm39) missense probably damaging 1.00
R9308:Vmn2r17 UTSW 5 109,600,505 (GRCm39) missense probably damaging 0.98
R9378:Vmn2r17 UTSW 5 109,575,732 (GRCm39) missense possibly damaging 0.94
R9597:Vmn2r17 UTSW 5 109,575,669 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGACTGTCACTTTTGCACACC -3'
(R):5'- GGGCCATTTATAAGACAACATTGC -3'

Sequencing Primer
(F):5'- GTCACTTTTGCACACCACAATGG -3'
(R):5'- TGAAATGTAAGAACCTTTACCTGCTG -3'
Posted On 2015-04-02