Incidental Mutation 'R3832:Zfp777'
ID 274053
Institutional Source Beutler Lab
Gene Symbol Zfp777
Ensembl Gene ENSMUSG00000071477
Gene Name zinc finger protein 777
Synonyms 2500002G23Rik
MMRRC Submission 040887-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.837) question?
Stock # R3832 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 48001122-48025845 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 48021149 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 158 (T158A)
Ref Sequence ENSEMBL: ENSMUSP00000117227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095944] [ENSMUST00000114583] [ENSMUST00000125385] [ENSMUST00000147281]
AlphaFold B9EKF4
Predicted Effect probably benign
Transcript: ENSMUST00000095944
AA Change: T158A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000093637
Gene: ENSMUSG00000071477
AA Change: T158A

DomainStartEndE-ValueType
Pfam:DUF3669 177 256 4.3e-12 PFAM
KRAB 284 344 1.6e-29 SMART
low complexity region 422 433 N/A INTRINSIC
coiled coil region 454 477 N/A INTRINSIC
low complexity region 489 505 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 539 555 N/A INTRINSIC
ZnF_C2H2 557 579 1.2e-5 SMART
ZnF_C2H2 585 607 3.8e-5 SMART
ZnF_C2H2 646 668 1.1e-6 SMART
ZnF_C2H2 674 696 4.6e-6 SMART
ZnF_C2H2 704 726 3.2e-7 SMART
ZnF_C2H2 732 754 3.3e-6 SMART
ZnF_C2H2 760 782 8.4e-6 SMART
ZnF_C2H2 788 810 4.9e-5 SMART
ZnF_C2H2 816 838 1.1e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114583
AA Change: T202A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000110230
Gene: ENSMUSG00000071477
AA Change: T202A

DomainStartEndE-ValueType
low complexity region 2 24 N/A INTRINSIC
Pfam:DUF3669 231 298 4.7e-12 PFAM
KRAB 328 388 3.96e-27 SMART
low complexity region 466 477 N/A INTRINSIC
coiled coil region 498 521 N/A INTRINSIC
low complexity region 533 549 N/A INTRINSIC
low complexity region 564 576 N/A INTRINSIC
low complexity region 583 599 N/A INTRINSIC
ZnF_C2H2 601 623 2.95e-3 SMART
ZnF_C2H2 629 651 8.94e-3 SMART
ZnF_C2H2 690 712 2.43e-4 SMART
ZnF_C2H2 718 740 1.12e-3 SMART
ZnF_C2H2 748 770 7.49e-5 SMART
ZnF_C2H2 776 798 7.9e-4 SMART
ZnF_C2H2 804 826 1.95e-3 SMART
ZnF_C2H2 832 854 1.18e-2 SMART
ZnF_C2H2 860 882 2.53e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125385
Predicted Effect probably benign
Transcript: ENSMUST00000147281
AA Change: T158A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect unknown
Transcript: ENSMUST00000148362
AA Change: T10A
SMART Domains Protein: ENSMUSP00000116303
Gene: ENSMUSG00000071477
AA Change: T10A

DomainStartEndE-ValueType
Pfam:DUF3669 40 107 6.1e-13 PFAM
KRAB 137 197 3.96e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175187
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203645
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 A C 15: 94,229,339 (GRCm39) C927G probably damaging Het
Afdn T A 17: 14,116,436 (GRCm39) D190E probably benign Het
Aldh1a7 T C 19: 20,685,602 (GRCm39) Y316C probably damaging Het
Arhgef38 T C 3: 132,912,686 (GRCm39) R118G possibly damaging Het
Bcar3 A G 3: 122,220,298 (GRCm39) D65G probably damaging Het
Cacna1i T C 15: 80,240,388 (GRCm39) F370S probably damaging Het
Cacnb2 A T 2: 14,986,236 (GRCm39) I338F probably damaging Het
Cblc T C 7: 19,526,097 (GRCm39) M238V probably damaging Het
Ccdc3 A G 2: 5,233,953 (GRCm39) N259S probably benign Het
Cep55 A G 19: 38,041,560 (GRCm39) probably benign Het
Col6a1 T C 10: 76,546,951 (GRCm39) D757G unknown Het
Csmd3 CCTTTGCGCTT CCTT 15: 47,604,632 (GRCm39) probably null Het
Cyb5d2 G T 11: 72,686,349 (GRCm39) S80R possibly damaging Het
Cyfip2 T C 11: 46,152,333 (GRCm39) D485G probably benign Het
Cyp27b1 G T 10: 126,886,929 (GRCm39) V382L probably damaging Het
Erich3 G A 3: 154,467,998 (GRCm39) V817M probably damaging Het
Gdf6 T C 4: 9,844,568 (GRCm39) S31P probably benign Het
Gtsf1 T C 15: 103,333,902 (GRCm39) I25V probably damaging Het
Hephl1 T C 9: 14,981,044 (GRCm39) E796G probably damaging Het
Iglv2 A T 16: 19,079,593 (GRCm39) M1K probably null Het
Kif26b GAAA GAA 1: 178,744,181 (GRCm39) probably null Het
Klhl28 C A 12: 64,998,195 (GRCm39) G433V probably damaging Het
Lipn T C 19: 34,046,933 (GRCm39) probably null Het
Lypd10 T A 7: 24,413,712 (GRCm39) S243T probably benign Het
Mapk7 A G 11: 61,380,680 (GRCm39) S641P possibly damaging Het
Med22 A G 2: 26,800,379 (GRCm39) S17P probably damaging Het
Or14c44 A T 7: 86,062,401 (GRCm39) Y277F probably damaging Het
Or14j5 T C 17: 38,162,071 (GRCm39) V196A probably benign Het
Otud1 G C 2: 19,662,951 (GRCm39) A27P possibly damaging Het
Pcdhga6 A T 18: 37,841,479 (GRCm39) N400Y probably damaging Het
Pdgfd T C 9: 6,359,762 (GRCm39) S278P probably damaging Het
Pdzd7 A T 19: 45,028,693 (GRCm39) V150E probably damaging Het
Peak1 T C 9: 56,165,667 (GRCm39) S754G probably benign Het
Phf14 A G 6: 11,933,873 (GRCm39) probably null Het
Phlpp1 G A 1: 106,320,327 (GRCm39) E1441K probably damaging Het
Piezo2 A G 18: 63,214,733 (GRCm39) probably null Het
Pikfyve G A 1: 65,283,579 (GRCm39) V739I probably damaging Het
Plcg1 T G 2: 160,596,357 (GRCm39) M651R possibly damaging Het
Prex2 T C 1: 11,226,588 (GRCm39) probably benign Het
Pus3 G C 9: 35,477,874 (GRCm39) G369R probably benign Het
Rab11fip1 G A 8: 27,642,774 (GRCm39) T675I probably benign Het
Scarf1 T C 11: 75,406,078 (GRCm39) C121R probably damaging Het
Sco1 T C 11: 66,944,605 (GRCm39) V76A probably damaging Het
Slc39a8 T A 3: 135,554,894 (GRCm39) C113S probably damaging Het
Slit3 A T 11: 35,579,509 (GRCm39) S1229C probably null Het
Snd1 G T 6: 28,531,403 (GRCm39) probably benign Het
Tbc1d9 A G 8: 83,960,292 (GRCm39) S182G probably damaging Het
Tecta A C 9: 42,250,329 (GRCm39) F1816C probably damaging Het
Tekt1 T C 11: 72,245,645 (GRCm39) N170S probably benign Het
Trim47 T C 11: 115,998,783 (GRCm39) T279A probably benign Het
Ttll4 A G 1: 74,725,550 (GRCm39) K653E probably damaging Het
Vcam1 T C 3: 115,908,140 (GRCm39) T641A possibly damaging Het
Vmn1r16 A G 6: 57,300,212 (GRCm39) F137L probably benign Het
Vmn2r17 T A 5: 109,576,262 (GRCm39) W378R probably damaging Het
Zp1 T C 19: 10,893,888 (GRCm39) D439G probably damaging Het
Other mutations in Zfp777
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01530:Zfp777 APN 6 48,020,918 (GRCm39) missense probably damaging 1.00
IGL01916:Zfp777 APN 6 48,002,276 (GRCm39) missense probably damaging 1.00
IGL01959:Zfp777 APN 6 48,021,275 (GRCm39) missense probably benign
IGL02167:Zfp777 APN 6 48,021,460 (GRCm39) missense probably damaging 0.98
IGL03150:Zfp777 APN 6 48,021,059 (GRCm39) missense probably damaging 1.00
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0372:Zfp777 UTSW 6 48,021,410 (GRCm39) missense possibly damaging 0.62
R0762:Zfp777 UTSW 6 48,006,294 (GRCm39) missense probably damaging 1.00
R1300:Zfp777 UTSW 6 48,002,704 (GRCm39) missense probably benign 0.43
R1727:Zfp777 UTSW 6 48,020,824 (GRCm39) missense probably damaging 0.99
R1906:Zfp777 UTSW 6 48,018,995 (GRCm39) missense probably damaging 0.99
R2047:Zfp777 UTSW 6 48,021,280 (GRCm39) missense probably benign
R2097:Zfp777 UTSW 6 48,021,176 (GRCm39) missense probably benign 0.08
R2211:Zfp777 UTSW 6 48,020,819 (GRCm39) missense possibly damaging 0.79
R2898:Zfp777 UTSW 6 48,002,594 (GRCm39) missense probably damaging 0.97
R3123:Zfp777 UTSW 6 48,006,050 (GRCm39) unclassified probably benign
R4019:Zfp777 UTSW 6 48,019,046 (GRCm39) missense probably damaging 1.00
R4077:Zfp777 UTSW 6 48,002,456 (GRCm39) missense probably benign
R4471:Zfp777 UTSW 6 48,019,041 (GRCm39) missense probably damaging 1.00
R5021:Zfp777 UTSW 6 48,019,061 (GRCm39) missense probably damaging 0.99
R5030:Zfp777 UTSW 6 48,014,601 (GRCm39) missense probably damaging 0.99
R5819:Zfp777 UTSW 6 48,014,522 (GRCm39) missense probably damaging 0.99
R6544:Zfp777 UTSW 6 48,021,419 (GRCm39) missense probably damaging 0.98
R6736:Zfp777 UTSW 6 48,001,790 (GRCm39) missense probably damaging 0.99
R6971:Zfp777 UTSW 6 48,001,625 (GRCm39) missense probably damaging 1.00
R7240:Zfp777 UTSW 6 48,021,383 (GRCm39) missense probably benign 0.00
R7258:Zfp777 UTSW 6 48,002,731 (GRCm39) missense probably damaging 0.99
R7586:Zfp777 UTSW 6 48,006,152 (GRCm39) missense probably benign 0.33
R7833:Zfp777 UTSW 6 48,002,072 (GRCm39) missense probably damaging 0.99
R7947:Zfp777 UTSW 6 48,001,645 (GRCm39) missense probably damaging 1.00
R8136:Zfp777 UTSW 6 48,021,559 (GRCm39) missense probably benign 0.25
R8151:Zfp777 UTSW 6 48,006,075 (GRCm39) nonsense probably null
R8348:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8448:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8942:Zfp777 UTSW 6 48,006,125 (GRCm39) missense probably benign 0.25
R8983:Zfp777 UTSW 6 48,006,158 (GRCm39) missense probably damaging 1.00
R9205:Zfp777 UTSW 6 48,002,521 (GRCm39) missense probably benign 0.07
R9397:Zfp777 UTSW 6 48,021,190 (GRCm39) missense probably benign 0.00
R9562:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
R9565:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
RF008:Zfp777 UTSW 6 48,018,982 (GRCm39) nonsense probably null
Z1177:Zfp777 UTSW 6 48,002,168 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTCTCCAGATGATTTGCGAAC -3'
(R):5'- GAAACCCAGTGCTCTCCTTC -3'

Sequencing Primer
(F):5'- GATGATTTGCGAACTCCACAG -3'
(R):5'- GCTCTCCTTCAGCAGCTG -3'
Posted On 2015-04-02