Mutagenetix > Incidental Mutations

Incidental Mutation 'R3815:Olfr876'

274246

Institutional Source

Beutler Lab

Gene Symbol

Olfr876

Ensembl Gene

ENSMUSG00000066750

Gene Name

olfactory receptor 876

Synonyms

GA_x6K02T2PVTD-31489645-31490577, MOR161-1

MMRRC Submission

040770-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R3815 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

37803031-37808144 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 37804169 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Leucine at position 86 (S86L)

Ref Sequence

ENSEMBL: ENSMUSP00000149930 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086064] [ENSMUST00000213368] [ENSMUST00000215287]

Predicted Effect

probably benign
Transcript: ENSMUST00000086064
AA Change: S86L

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000083231
Gene: ENSMUSG00000066750
AA Change: S86L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	307	1.6e-47	PFAM
Pfam:7tm_1	40	289	3.2e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213368
AA Change: S86L

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

Predicted Effect

probably benign
Transcript: ENSMUST00000215287
AA Change: S86L

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

Meta Mutation Damage Score

0.0833

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.7%
20x: 96.2%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001L19Rik	A	G	13: 68,611,225	H106R	probably damaging	Het
Aak1	T	C	6: 86,959,042		probably benign	Het
Aldh18a1	A	G	19: 40,570,500	S299P	probably damaging	Het
Als2cr12	T	G	1: 58,659,005	N379T	probably damaging	Het
Ankrd6	A	C	4: 32,806,206	S618R	probably benign	Het
Apobec3	G	T	15: 79,899,100	R126M	possibly damaging	Het
Arl8b	T	A	6: 108,813,697	V65D	probably damaging	Het
AW554918	C	T	18: 25,400,047	R253C	probably benign	Het
Cd177	A	G	7: 24,754,392	V358A	probably benign	Het
Cdca7l	G	A	12: 117,872,213	V95I	probably damaging	Het
Ces1e	A	G	8: 93,201,839		probably null	Het
Coq5	T	G	5: 115,295,898	F306V	probably damaging	Het
Cpsf1	A	G	15: 76,601,149	V501A	probably benign	Het
Csmd1	C	T	8: 16,002,522	A2201T	probably damaging	Het
Cul5	T	A	9: 53,622,943	I630L	probably benign	Het
Cyp4a12b	A	T	4: 115,432,470	D178V	probably damaging	Het
Dedd	A	G	1: 171,338,901	E135G	probably benign	Het
Ecel1	A	G	1: 87,152,900	F368S	probably damaging	Het
Ext1	A	C	15: 53,345,089	I92S	probably benign	Het
Fbxw5	A	T	2: 25,503,564	D268V	possibly damaging	Het
Gen1	A	T	12: 11,252,033	V192E	possibly damaging	Het
Gm11077	T	G	6: 140,729,315	V11G	unknown	Het
Ift88	A	T	14: 57,440,981	E150V	possibly damaging	Het
Kcna1	T	C	6: 126,643,046	R104G	probably damaging	Het
Kcnd3	C	T	3: 105,658,766	A421V	probably damaging	Het
Krt82	A	G	15: 101,550,600	S2P	probably damaging	Het
Luc7l2	T	C	6: 38,570,591	S69P	possibly damaging	Het
Ly9	G	T	1: 171,589,085	T537N	possibly damaging	Het
Mamstr	G	T	7: 45,644,532	R20L	probably damaging	Het
Nav1	C	A	1: 135,471,124	K573N	possibly damaging	Het
Olfr1457	T	C	19: 13,094,913	H245R	probably damaging	Het
Olfr889	A	T	9: 38,116,626	T277S	possibly damaging	Het
Olfr922	A	G	9: 38,816,426	K308E	possibly damaging	Het
Palld	T	A	8: 61,549,837		probably benign	Het
Pcdha2	A	G	18: 36,941,695	Y793C	probably benign	Het
Pcdhb4	A	T	18: 37,308,012	D125V	probably damaging	Het
Pomgnt1	T	A	4: 116,153,942		probably null	Het
Ppp1r9b	A	T	11: 94,992,533	E329V	probably damaging	Het
Rarres1	T	A	3: 67,515,321	D32V	probably benign	Het
Rhobtb1	A	G	10: 69,285,693	H53R	possibly damaging	Het
Ryr1	A	T	7: 29,072,902	S2494T	probably damaging	Het
Sapcd2	G	A	2: 25,373,506		probably benign	Het
Secisbp2l	C	T	2: 125,740,737	G933D	possibly damaging	Het
Senp1	A	C	15: 98,056,832	D490E	probably damaging	Het
Sfrp5	C	T	19: 42,198,791	R280H	probably benign	Het
Skint5	A	G	4: 113,629,122		probably benign	Het
Skint5	G	A	4: 113,846,299	T499I	possibly damaging	Het
Smad1	G	A	8: 79,343,730	A393V	probably benign	Het
Sorl1	A	G	9: 42,064,049	L487P	possibly damaging	Het
Spire1	G	T	18: 67,506,663	T273K	probably benign	Het
Tep1	T	C	14: 50,868,315	T83A	possibly damaging	Het
Top2b	T	G	14: 16,409,189	I777M	probably damaging	Het
Ttn	T	A	2: 76,721,733	R29441*	probably null	Het
Wdr37	A	G	13: 8,853,596		probably benign	Het

Other mutations in Olfr876

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00973:Olfr876	APN	9	37804782	missense	probably damaging	1.00
IGL01330:Olfr876	APN	9	37804220	missense	probably damaging	1.00
IGL02105:Olfr876	APN	9	37804595	missense	possibly damaging	0.53
IGL02505:Olfr876	APN	9	37804331	missense	probably benign	0.08
R1543:Olfr876	UTSW	9	37803947	missense	possibly damaging	0.94
R1768:Olfr876	UTSW	9	37804303	missense	probably damaging	1.00
R1960:Olfr876	UTSW	9	37803946	missense	probably benign	0.01
R2567:Olfr876	UTSW	9	37804213	missense	probably damaging	1.00
R3816:Olfr876	UTSW	9	37804169	missense	probably benign	0.05
R3817:Olfr876	UTSW	9	37804169	missense	probably benign	0.05
R3819:Olfr876	UTSW	9	37804169	missense	probably benign	0.05
R4364:Olfr876	UTSW	9	37804190	missense	probably benign	0.19
R4366:Olfr876	UTSW	9	37804190	missense	probably benign	0.19
R4620:Olfr876	UTSW	9	37804819	missense	probably benign	0.02
R5530:Olfr876	UTSW	9	37804807	missense	probably benign	0.00
R6199:Olfr876	UTSW	9	37804881	splice site	probably null
R6238:Olfr876	UTSW	9	37804021	missense	probably benign	0.26
R6893:Olfr876	UTSW	9	37804845	makesense	probably null
R7404:Olfr876	UTSW	9	37803961	missense	possibly damaging	0.80
R7806:Olfr876	UTSW	9	37804576	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- AGTTCATCCTTGCAGGCCTG -3'
(R):5'- TCAGCCTTGCCATGGATATG -3'

Sequencing Primer
(F):5'- ATCCTTGCAGGCCTGACAGAC -3'
(R):5'- GGGCCATGGCTCCAACAAAAC -3'

Posted On

2015-04-02