Incidental Mutation 'IGL00941:Gnat3'
ID 27451
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gnat3
Ensembl Gene ENSMUSG00000028777
Gene Name G protein subunit alpha transducin 3
Synonyms Gtn, Ggust, alpha-gustducin
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00941
Quality Score
Status
Chromosome 5
Chromosomal Location 18167568-18224666 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 18208749 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000030561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030561]
AlphaFold Q3V3I2
Predicted Effect probably benign
Transcript: ENSMUST00000030561
SMART Domains Protein: ENSMUSP00000030561
Gene: ENSMUSG00000028777

DomainStartEndE-ValueType
G_alpha 13 353 3.06e-221 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]
PHENOTYPE: Homozygous mutation of this gene results in abnormal taste sensitivity. Mice show reduced behavioral and electrophysiological responses to bitter, sweet, and unami compounds. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A C 17: 24,536,104 (GRCm39) I521S probably damaging Het
Ace A T 11: 105,870,376 (GRCm39) K265I probably benign Het
Acss3 A G 10: 106,889,187 (GRCm39) probably null Het
Aldh3a2 A G 11: 61,153,082 (GRCm39) Y215H probably damaging Het
Clk2 A G 3: 89,082,729 (GRCm39) M393V probably damaging Het
Cyc1 A G 15: 76,229,365 (GRCm39) I242V probably benign Het
Evpl G A 11: 116,118,727 (GRCm39) L657F probably benign Het
Fbxw10 G A 11: 62,764,327 (GRCm39) V675M probably damaging Het
Fgf21 A G 7: 45,264,597 (GRCm39) V45A probably damaging Het
Gm5134 T C 10: 75,836,255 (GRCm39) I412T possibly damaging Het
Hk3 C T 13: 55,162,239 (GRCm39) probably null Het
Ifna12 A T 4: 88,521,551 (GRCm39) probably benign Het
Ipp A G 4: 116,389,856 (GRCm39) M471V possibly damaging Het
Kcnj1 G A 9: 32,307,794 (GRCm39) V73I probably benign Het
Kin G A 2: 10,085,515 (GRCm39) R25H probably damaging Het
Kin T C 2: 10,085,517 (GRCm39) W26R probably damaging Het
Mical2 T C 7: 111,920,652 (GRCm39) probably benign Het
Mllt1 A T 17: 57,202,086 (GRCm39) S428R probably damaging Het
Ppm1k T A 6: 57,501,740 (GRCm39) H141L probably benign Het
Septin4 G T 11: 87,480,599 (GRCm39) C392F probably damaging Het
Slc26a11 T C 11: 119,270,727 (GRCm39) F550L probably benign Het
Ssb T A 2: 69,701,179 (GRCm39) probably null Het
Stk36 T A 1: 74,663,093 (GRCm39) M588K possibly damaging Het
Ubqln4 G A 3: 88,471,808 (GRCm39) A415T probably benign Het
Zfp839 C A 12: 110,827,382 (GRCm39) S424R probably damaging Het
Zkscan6 G T 11: 65,705,573 (GRCm39) G95W probably damaging Het
Other mutations in Gnat3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01023:Gnat3 APN 5 18,208,826 (GRCm39) missense probably damaging 1.00
IGL01997:Gnat3 APN 5 18,204,721 (GRCm39) nonsense probably null
PIT4377001:Gnat3 UTSW 5 18,220,557 (GRCm39) missense
R0556:Gnat3 UTSW 5 18,224,596 (GRCm39) missense probably damaging 1.00
R1624:Gnat3 UTSW 5 18,208,841 (GRCm39) missense possibly damaging 0.66
R1934:Gnat3 UTSW 5 18,224,508 (GRCm39) missense possibly damaging 0.74
R2319:Gnat3 UTSW 5 18,224,624 (GRCm39) missense probably benign 0.17
R3928:Gnat3 UTSW 5 18,208,892 (GRCm39) splice site probably benign
R4169:Gnat3 UTSW 5 18,208,862 (GRCm39) missense probably damaging 1.00
R4420:Gnat3 UTSW 5 18,204,799 (GRCm39) missense probably damaging 1.00
R4632:Gnat3 UTSW 5 18,220,364 (GRCm39) splice site probably null
R4651:Gnat3 UTSW 5 18,220,568 (GRCm39) missense probably damaging 1.00
R4652:Gnat3 UTSW 5 18,220,568 (GRCm39) missense probably damaging 1.00
R5471:Gnat3 UTSW 5 18,196,322 (GRCm39) missense probably damaging 1.00
R7460:Gnat3 UTSW 5 18,204,656 (GRCm39) missense
R7627:Gnat3 UTSW 5 18,204,746 (GRCm39) missense
R7637:Gnat3 UTSW 5 18,208,770 (GRCm39) missense
R8342:Gnat3 UTSW 5 18,208,838 (GRCm39) missense
R8428:Gnat3 UTSW 5 18,220,312 (GRCm39) missense possibly damaging 0.89
X0064:Gnat3 UTSW 5 18,208,838 (GRCm39) missense possibly damaging 0.74
Z1088:Gnat3 UTSW 5 18,220,321 (GRCm39) missense probably damaging 1.00
Z1177:Gnat3 UTSW 5 18,220,311 (GRCm39) nonsense probably null
Posted On 2013-04-17