Incidental Mutation 'IGL00941:Gnat3'
ID |
27451 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Gnat3
|
Ensembl Gene |
ENSMUSG00000028777 |
Gene Name |
G protein subunit alpha transducin 3 |
Synonyms |
Gtn, Ggust, alpha-gustducin |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL00941
|
Quality Score |
|
Status
|
|
Chromosome |
5 |
Chromosomal Location |
18167568-18224666 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
T to C
at 18208749 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000030561
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030561]
|
AlphaFold |
Q3V3I2 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000030561
|
SMART Domains |
Protein: ENSMUSP00000030561 Gene: ENSMUSG00000028777
Domain | Start | End | E-Value | Type |
G_alpha
|
13 |
353 |
3.06e-221 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015] PHENOTYPE: Homozygous mutation of this gene results in abnormal taste sensitivity. Mice show reduced behavioral and electrophysiological responses to bitter, sweet, and unami compounds. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 26 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca17 |
A |
C |
17: 24,536,104 (GRCm39) |
I521S |
probably damaging |
Het |
Ace |
A |
T |
11: 105,870,376 (GRCm39) |
K265I |
probably benign |
Het |
Acss3 |
A |
G |
10: 106,889,187 (GRCm39) |
|
probably null |
Het |
Aldh3a2 |
A |
G |
11: 61,153,082 (GRCm39) |
Y215H |
probably damaging |
Het |
Clk2 |
A |
G |
3: 89,082,729 (GRCm39) |
M393V |
probably damaging |
Het |
Cyc1 |
A |
G |
15: 76,229,365 (GRCm39) |
I242V |
probably benign |
Het |
Evpl |
G |
A |
11: 116,118,727 (GRCm39) |
L657F |
probably benign |
Het |
Fbxw10 |
G |
A |
11: 62,764,327 (GRCm39) |
V675M |
probably damaging |
Het |
Fgf21 |
A |
G |
7: 45,264,597 (GRCm39) |
V45A |
probably damaging |
Het |
Gm5134 |
T |
C |
10: 75,836,255 (GRCm39) |
I412T |
possibly damaging |
Het |
Hk3 |
C |
T |
13: 55,162,239 (GRCm39) |
|
probably null |
Het |
Ifna12 |
A |
T |
4: 88,521,551 (GRCm39) |
|
probably benign |
Het |
Ipp |
A |
G |
4: 116,389,856 (GRCm39) |
M471V |
possibly damaging |
Het |
Kcnj1 |
G |
A |
9: 32,307,794 (GRCm39) |
V73I |
probably benign |
Het |
Kin |
G |
A |
2: 10,085,515 (GRCm39) |
R25H |
probably damaging |
Het |
Kin |
T |
C |
2: 10,085,517 (GRCm39) |
W26R |
probably damaging |
Het |
Mical2 |
T |
C |
7: 111,920,652 (GRCm39) |
|
probably benign |
Het |
Mllt1 |
A |
T |
17: 57,202,086 (GRCm39) |
S428R |
probably damaging |
Het |
Ppm1k |
T |
A |
6: 57,501,740 (GRCm39) |
H141L |
probably benign |
Het |
Septin4 |
G |
T |
11: 87,480,599 (GRCm39) |
C392F |
probably damaging |
Het |
Slc26a11 |
T |
C |
11: 119,270,727 (GRCm39) |
F550L |
probably benign |
Het |
Ssb |
T |
A |
2: 69,701,179 (GRCm39) |
|
probably null |
Het |
Stk36 |
T |
A |
1: 74,663,093 (GRCm39) |
M588K |
possibly damaging |
Het |
Ubqln4 |
G |
A |
3: 88,471,808 (GRCm39) |
A415T |
probably benign |
Het |
Zfp839 |
C |
A |
12: 110,827,382 (GRCm39) |
S424R |
probably damaging |
Het |
Zkscan6 |
G |
T |
11: 65,705,573 (GRCm39) |
G95W |
probably damaging |
Het |
|
Other mutations in Gnat3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01023:Gnat3
|
APN |
5 |
18,208,826 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01997:Gnat3
|
APN |
5 |
18,204,721 (GRCm39) |
nonsense |
probably null |
|
PIT4377001:Gnat3
|
UTSW |
5 |
18,220,557 (GRCm39) |
missense |
|
|
R0556:Gnat3
|
UTSW |
5 |
18,224,596 (GRCm39) |
missense |
probably damaging |
1.00 |
R1624:Gnat3
|
UTSW |
5 |
18,208,841 (GRCm39) |
missense |
possibly damaging |
0.66 |
R1934:Gnat3
|
UTSW |
5 |
18,224,508 (GRCm39) |
missense |
possibly damaging |
0.74 |
R2319:Gnat3
|
UTSW |
5 |
18,224,624 (GRCm39) |
missense |
probably benign |
0.17 |
R3928:Gnat3
|
UTSW |
5 |
18,208,892 (GRCm39) |
splice site |
probably benign |
|
R4169:Gnat3
|
UTSW |
5 |
18,208,862 (GRCm39) |
missense |
probably damaging |
1.00 |
R4420:Gnat3
|
UTSW |
5 |
18,204,799 (GRCm39) |
missense |
probably damaging |
1.00 |
R4632:Gnat3
|
UTSW |
5 |
18,220,364 (GRCm39) |
splice site |
probably null |
|
R4651:Gnat3
|
UTSW |
5 |
18,220,568 (GRCm39) |
missense |
probably damaging |
1.00 |
R4652:Gnat3
|
UTSW |
5 |
18,220,568 (GRCm39) |
missense |
probably damaging |
1.00 |
R5471:Gnat3
|
UTSW |
5 |
18,196,322 (GRCm39) |
missense |
probably damaging |
1.00 |
R7460:Gnat3
|
UTSW |
5 |
18,204,656 (GRCm39) |
missense |
|
|
R7627:Gnat3
|
UTSW |
5 |
18,204,746 (GRCm39) |
missense |
|
|
R7637:Gnat3
|
UTSW |
5 |
18,208,770 (GRCm39) |
missense |
|
|
R8342:Gnat3
|
UTSW |
5 |
18,208,838 (GRCm39) |
missense |
|
|
R8428:Gnat3
|
UTSW |
5 |
18,220,312 (GRCm39) |
missense |
possibly damaging |
0.89 |
X0064:Gnat3
|
UTSW |
5 |
18,208,838 (GRCm39) |
missense |
possibly damaging |
0.74 |
Z1088:Gnat3
|
UTSW |
5 |
18,220,321 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Gnat3
|
UTSW |
5 |
18,220,311 (GRCm39) |
nonsense |
probably null |
|
|
Posted On |
2013-04-17 |