Incidental Mutation 'R3805:Crct1'
ID274538
Institutional Source Beutler Lab
Gene Symbol Crct1
Ensembl Gene ENSMUSG00000027913
Gene Namecysteine-rich C-terminal 1
SynonymsNice-1, 2300002G24Rik
MMRRC Submission 040762-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #R3805 (G1)
Quality Score225
Status Validated
Chromosome3
Chromosomal Location93014205-93015687 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) C to A at 93014707 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029520] [ENSMUST00000029521] [ENSMUST00000107301] [ENSMUST00000193944]
Predicted Effect probably benign
Transcript: ENSMUST00000029520
SMART Domains Protein: ENSMUSP00000029520
Gene: ENSMUSG00000027912

DomainStartEndE-ValueType
Pfam:LCE 9 96 5.4e-18 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000029521
AA Change: R41M
SMART Domains Protein: ENSMUSP00000029521
Gene: ENSMUSG00000027913
AA Change: R41M

DomainStartEndE-ValueType
low complexity region 12 102 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000107301
AA Change: R41M
SMART Domains Protein: ENSMUSP00000102922
Gene: ENSMUSG00000027913
AA Change: R41M

DomainStartEndE-ValueType
Pfam:NICE-1 5 100 5.4e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193944
Meta Mutation Damage Score 0.1444 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.7%
  • 20x: 96.1%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,794,154 C172* probably null Het
Aebp2 GCGGCC GCGGCCGGCC 6: 140,643,949 probably null Het
Ano5 T C 7: 51,576,650 F584L probably benign Het
Ap1b1 T A 11: 5,033,225 probably null Het
Bicd1 T A 6: 149,518,991 L780M probably damaging Het
Ccdc138 T C 10: 58,561,997 I553T possibly damaging Het
Col1a2 G A 6: 4,518,822 probably benign Het
Ctu1 T C 7: 43,676,673 L252P probably damaging Het
Dhrs2 A T 14: 55,234,748 N32I probably benign Het
Dnah1 A T 14: 31,294,763 M1599K possibly damaging Het
Eri2 A T 7: 119,786,008 C423* probably null Het
Fam169a G A 13: 97,097,684 V155I probably benign Het
Get4 G T 5: 139,252,531 V23F probably damaging Het
Hdac3 A G 18: 37,945,692 probably null Het
Herc3 C A 6: 58,916,850 H970Q probably damaging Het
Htt A G 5: 34,877,204 probably null Het
Ifit1 A G 19: 34,648,156 I231V probably damaging Het
Lingo4 A G 3: 94,402,100 D115G probably damaging Het
Lrrc7 T C 3: 158,185,493 I346V probably benign Het
Map7d1 A T 4: 126,237,291 probably null Het
Morf4l1 A G 9: 90,095,143 S203P probably benign Het
Naaladl1 A G 19: 6,114,865 T628A probably benign Het
Nlrp9a T A 7: 26,564,852 C643* probably null Het
Olfr1187-ps1 A T 2: 88,540,356 noncoding transcript Het
Olfr1270 T G 2: 90,148,461 probably benign Het
Oxtr T C 6: 112,477,186 K39R probably benign Het
Ppp4r4 T A 12: 103,600,366 M24K probably damaging Het
Ppp6r2 T C 15: 89,265,639 F256L probably benign Het
Robo4 A T 9: 37,404,438 D329V possibly damaging Het
Rsph10b G A 5: 143,958,388 probably null Het
Slc9b2 T C 3: 135,324,588 L222P probably damaging Het
Speer4a C T 5: 26,035,084 E223K possibly damaging Het
St18 T A 1: 6,802,353 L104H probably damaging Het
Tmem184c C A 8: 77,596,875 D453Y unknown Het
Trpv1 A T 11: 73,253,053 N237I probably damaging Het
Vmn2r77 T A 7: 86,795,160 L7* probably null Het
Other mutations in Crct1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3706:Crct1 UTSW 3 93014707 unclassified probably benign
R3745:Crct1 UTSW 3 93014707 unclassified probably benign
R3925:Crct1 UTSW 3 93014707 unclassified probably benign
R3926:Crct1 UTSW 3 93014707 unclassified probably benign
R4757:Crct1 UTSW 3 93014786 nonsense probably null
R4921:Crct1 UTSW 3 93014825 unclassified probably benign
Predicted Primers PCR Primer
(F):5'- AGCAGCCTGAACTCTGATTG -3'
(R):5'- CCAGACAGACTTTTCTCTAAGGC -3'

Sequencing Primer
(F):5'- CAGCCTGAACTCTGATTGTTGCAG -3'
(R):5'- AAGTTCTGTGTTCCACTATAGGGAAG -3'
Posted On2015-04-02