Mutagenetix > Incidental Mutations

Incidental Mutation 'R3765:Olfr311'

274667

Institutional Source

Beutler Lab

Gene Symbol

Olfr311

Ensembl Gene

ENSMUSG00000094805

Gene Name

olfactory receptor 311

Synonyms

MOR222-1, GA_x6K02T2NKPP-565870-564944

MMRRC Submission

040742-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.095) question?

Stock #

R3765 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

58839251-58844111 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 58841294 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 60 (F60S)

Ref Sequence

ENSEMBL: ENSMUSP00000150870 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071625] [ENSMUST00000216473]

Predicted Effect

probably damaging
Transcript: ENSMUST00000071625
AA Change: F60S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071553
Gene: ENSMUSG00000094805
AA Change: F60S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	9e-52	PFAM
Pfam:7TM_GPCR_Srsx	33	215	1.7e-8	PFAM
Pfam:7tm_1	39	288	9.7e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214776

Predicted Effect

probably damaging
Transcript: ENSMUST00000216473
AA Change: F60S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap13	T	C	7: 75,608,837	V403A	probably benign	Het
Arid2	T	C	15: 96,370,714	S903P	probably benign	Het
Arl6ip6	T	A	2: 53,192,231	W37R	probably damaging	Het
Bag3	C	T	7: 128,540,271	T162I	probably benign	Het
C4b	G	A	17: 34,729,840	P1545S	probably damaging	Het
Ccdc185	T	A	1: 182,747,552	H524L	possibly damaging	Het
Cfap43	T	C	19: 47,835,575	N119S	probably benign	Het
Churc1	C	A	12: 76,773,283	S22*	probably null	Het
Crbn	T	C	6: 106,795,026	K106E	possibly damaging	Het
Dag1	C	T	9: 108,208,199	G581E	probably damaging	Het
Dpp4	T	A	2: 62,386,436	T92S	probably benign	Het
Fam135a	T	C	1: 24,055,877	T137A	possibly damaging	Het
Fermt1	T	C	2: 132,906,702	D667G	possibly damaging	Het
Foxl2	T	A	9: 98,955,986	I109N	probably damaging	Het
Frk	A	G	10: 34,484,005	M1V	probably null	Het
Fuk	A	G	8: 110,887,104	I775T	probably benign	Het
Gstm2	A	G	3: 107,984,030	F124S	probably damaging	Het
Hmcn1	T	C	1: 150,745,025	S1145G	possibly damaging	Het
Ints10	A	G	8: 68,825,119	T682A	possibly damaging	Het
Jmy	T	C	13: 93,464,711	M396V	possibly damaging	Het
Ldb3	A	T	14: 34,578,682		probably null	Het
Mre11a	A	G	9: 14,809,847	N354S	probably benign	Het
Nbea	A	G	3: 56,005,549	V939A	probably damaging	Het
Nphs1	T	C	7: 30,471,210	S928P	probably damaging	Het
Olfr1463	G	A	19: 13,234,431	M60I	probably damaging	Het
Olfr19	A	G	16: 16,673,315	V222A	probably benign	Het
Olfr954	T	A	9: 39,461,624	Y61*	probably null	Het
Pla2g12b	G	A	10: 59,421,501	V169M	probably damaging	Het
Polr1c	C	T	17: 46,247,924	V14M	probably damaging	Het
Prg4	G	A	1: 150,451,371	S898L	probably damaging	Het
Prmt6	C	A	3: 110,250,194	E260*	probably null	Het
Ptx4	A	G	17: 25,122,868	T106A	probably benign	Het
Rab3il1	A	G	19: 10,028,309	T87A	probably damaging	Het
Sbf2	A	G	7: 110,375,581	V783A	probably damaging	Het
Scn2a	A	C	2: 65,682,710	D209A	possibly damaging	Het
Setd2	T	C	9: 110,594,246	L345P	probably damaging	Het
Slc18b1	A	G	10: 23,798,749	D34G	probably damaging	Het
Slc9c1	A	T	16: 45,590,881	M934L	possibly damaging	Het
Slx4	A	G	16: 3,980,986	V1357A	probably damaging	Het
Spidr	T	C	16: 15,968,640	E413G	probably benign	Het
Taar1	A	G	10: 23,921,307	Y301C	probably damaging	Het
Tada2b	A	T	5: 36,476,417	D197E	probably benign	Het
Taf1c	G	T	8: 119,600,485	Y418*	probably null	Het
Tanc2	A	G	11: 105,914,970	D394G	probably damaging	Het
Tnpo3	T	C	6: 29,579,689	D235G	probably benign	Het
Tns3	G	A	11: 8,451,133	A1055V	probably benign	Het
Wdfy3	A	G	5: 101,861,400	Y2767H	probably damaging	Het
Zfhx3	A	G	8: 108,792,762	N172S	probably damaging	Het
Zfp839	T	C	12: 110,855,163	V137A	probably benign	Het

Other mutations in Olfr311

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02367:Olfr311	APN	11	58841512	missense	probably benign	0.10
H8786:Olfr311	UTSW	11	58841320	missense	probably benign	0.22
R0620:Olfr311	UTSW	11	58841443	missense	probably damaging	1.00
R0671:Olfr311	UTSW	11	58841855	missense	possibly damaging	0.94
R0827:Olfr311	UTSW	11	58841771	missense	probably damaging	1.00
R0839:Olfr311	UTSW	11	58841652	missense	probably benign
R0932:Olfr311	UTSW	11	58841714	missense	possibly damaging	0.92
R1117:Olfr311	UTSW	11	58841815	missense	possibly damaging	0.64
R1533:Olfr311	UTSW	11	58841966	missense	probably damaging	1.00
R1540:Olfr311	UTSW	11	58841651	missense	probably benign	0.01
R1595:Olfr311	UTSW	11	58841652	missense	probably benign
R1826:Olfr311	UTSW	11	58841431	missense	probably benign
R2857:Olfr311	UTSW	11	58841882	missense	probably benign	0.42
R2858:Olfr311	UTSW	11	58841882	missense	probably benign	0.42
R2859:Olfr311	UTSW	11	58841882	missense	probably benign	0.42
R3438:Olfr311	UTSW	11	58841872	nonsense	probably null
R3831:Olfr311	UTSW	11	58841860	missense	probably damaging	0.99
R4858:Olfr311	UTSW	11	58841207	missense	possibly damaging	0.86
R5651:Olfr311	UTSW	11	58841491	nonsense	probably null
R5979:Olfr311	UTSW	11	58841840	missense	probably damaging	1.00
R6316:Olfr311	UTSW	11	58841942	missense	probably damaging	1.00
R6717:Olfr311	UTSW	11	58841287	missense	probably damaging	1.00
R7163:Olfr311	UTSW	11	58841186	missense	probably benign	0.12
R7605:Olfr311	UTSW	11	58841500	missense	probably benign	0.00
R8328:Olfr311	UTSW	11	58841634	missense	probably benign	0.00
Z1186:Olfr311	UTSW	11	58841081	start gained	probably benign
Z1186:Olfr311	UTSW	11	58841119	missense	probably benign
Z1186:Olfr311	UTSW	11	58841206	missense	probably benign
Z1186:Olfr311	UTSW	11	58841743	missense	probably benign	0.16
Z1186:Olfr311	UTSW	11	58841789	missense	probably benign
Z1187:Olfr311	UTSW	11	58841081	start gained	probably benign
Z1187:Olfr311	UTSW	11	58841119	missense	probably benign
Z1187:Olfr311	UTSW	11	58841206	missense	probably benign
Z1187:Olfr311	UTSW	11	58841258	missense	probably benign
Z1187:Olfr311	UTSW	11	58841743	missense	probably benign	0.16
Z1187:Olfr311	UTSW	11	58841789	missense	probably benign
Z1188:Olfr311	UTSW	11	58841081	start gained	probably benign
Z1188:Olfr311	UTSW	11	58841119	missense	probably benign
Z1188:Olfr311	UTSW	11	58841206	missense	probably benign
Z1188:Olfr311	UTSW	11	58841258	missense	probably benign
Z1188:Olfr311	UTSW	11	58841743	missense	probably benign	0.16
Z1188:Olfr311	UTSW	11	58841789	missense	probably benign
Z1189:Olfr311	UTSW	11	58841081	start gained	probably benign
Z1189:Olfr311	UTSW	11	58841119	missense	probably benign
Z1189:Olfr311	UTSW	11	58841743	missense	probably benign	0.16
Z1189:Olfr311	UTSW	11	58841789	missense	probably benign
Z1190:Olfr311	UTSW	11	58841081	start gained	probably benign
Z1190:Olfr311	UTSW	11	58841119	missense	probably benign
Z1190:Olfr311	UTSW	11	58841206	missense	probably benign
Z1190:Olfr311	UTSW	11	58841258	missense	probably benign
Z1190:Olfr311	UTSW	11	58841743	missense	probably benign	0.16
Z1190:Olfr311	UTSW	11	58841789	missense	probably benign
Z1191:Olfr311	UTSW	11	58841081	start gained	probably benign
Z1191:Olfr311	UTSW	11	58841119	missense	probably benign
Z1191:Olfr311	UTSW	11	58841206	missense	probably benign
Z1191:Olfr311	UTSW	11	58841258	missense	probably benign
Z1191:Olfr311	UTSW	11	58841743	missense	probably benign	0.16
Z1191:Olfr311	UTSW	11	58841789	missense	probably benign
Z1192:Olfr311	UTSW	11	58841081	start gained	probably benign
Z1192:Olfr311	UTSW	11	58841119	missense	probably benign
Z1192:Olfr311	UTSW	11	58841206	missense	probably benign
Z1192:Olfr311	UTSW	11	58841743	missense	probably benign	0.16
Z1192:Olfr311	UTSW	11	58841789	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GAGCAGACATGGCCAATCAC -3'
(R):5'- GATGGTTCCATAGATCAGTGGTC -3'

Sequencing Primer
(F):5'- GACATGGCCAATCACACAAGAG -3'
(R):5'- ACCGGTCATAAGCCATGGC -3'

Posted On

2015-04-02