|Institutional Source||Beutler Lab|
|Gene Name||mannose receptor, C type 2|
|Synonyms||Endo180, uPARAP, novel lectin|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R3821 (G1)|
|Chromosomal Location||105292643-105351139 bp(+) (GRCm38)|
|Type of Mutation||splice site (5 bp from exon)|
|DNA Base Change (assembly)||G to A at 105348431 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000097909 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000021038] [ENSMUST00000100335]|
|Predicted Effect||probably benign
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (67/67)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mrc2||
(F):5'- CTTGAGCTGCCAGAGAAGAGTG -3'
(R):5'- CTGTGGAAGGAACCCATTGG -3'
(F):5'- GGTCTATCACCATAAGGAGAATCTGC -3'
(R):5'- CCATTGGGAAGGTGTGGGAATG -3'