Incidental Mutation 'R3808:Zfp267'
ID 275023
Institutional Source Beutler Lab
Gene Symbol Zfp267
Ensembl Gene ENSMUSG00000033883
Gene Name zinc finger protein 267
Synonyms D3Ertd254e
MMRRC Submission 040765-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R3808 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 36205233-36224491 bp(+) (GRCm39)
Type of Mutation splice site (2969 bp from exon)
DNA Base Change (assembly) T to G at 36219792 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165956] [ENSMUST00000197653] [ENSMUST00000205077]
AlphaFold A0A0G2JEM5
Predicted Effect possibly damaging
Transcript: ENSMUST00000165956
AA Change: F604C

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000131779
Gene: ENSMUSG00000033883
AA Change: F604C

DomainStartEndE-ValueType
KRAB 3 63 2.91e-34 SMART
ZnF_C2H2 342 364 1.08e-1 SMART
ZnF_C2H2 395 417 1.56e-2 SMART
ZnF_C2H2 423 445 3.11e-2 SMART
ZnF_C2H2 451 473 5.9e-3 SMART
ZnF_C2H2 479 501 1.82e-3 SMART
ZnF_C2H2 507 529 5.21e-4 SMART
ZnF_C2H2 535 557 1.84e-4 SMART
ZnF_C2H2 563 585 1.95e-3 SMART
ZnF_C2H2 591 613 2.05e-2 SMART
ZnF_C2H2 619 641 1.6e-4 SMART
ZnF_C2H2 647 669 5.21e-4 SMART
ZnF_C2H2 675 697 1.69e-3 SMART
ZnF_C2H2 703 725 2.61e-4 SMART
ZnF_C2H2 731 753 1.12e-3 SMART
ZnF_C2H2 759 779 3.85e1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000197653
AA Change: F605C

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000142829
Gene: ENSMUSG00000033883
AA Change: F605C

DomainStartEndE-ValueType
KRAB 4 64 1.2e-36 SMART
ZnF_C2H2 343 365 4.4e-4 SMART
ZnF_C2H2 396 418 6.7e-5 SMART
ZnF_C2H2 424 446 1.3e-4 SMART
ZnF_C2H2 452 474 2.5e-5 SMART
ZnF_C2H2 480 502 7.9e-6 SMART
ZnF_C2H2 508 530 2.2e-6 SMART
ZnF_C2H2 536 558 7.7e-7 SMART
ZnF_C2H2 564 586 8e-6 SMART
ZnF_C2H2 592 614 8.9e-5 SMART
ZnF_C2H2 620 642 6.6e-7 SMART
ZnF_C2H2 648 670 2.2e-6 SMART
ZnF_C2H2 676 698 7.1e-6 SMART
ZnF_C2H2 704 726 1.1e-6 SMART
ZnF_C2H2 732 754 4.8e-6 SMART
ZnF_C2H2 760 780 1.6e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000205077
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Aldh3a2 G T 11: 61,149,623 (GRCm39) L248M probably damaging Het
Als2 A G 1: 59,209,609 (GRCm39) S1458P probably benign Het
Aoc1l3 C T 6: 48,964,928 (GRCm39) P312L possibly damaging Het
Arhgap5 A G 12: 52,613,970 (GRCm39) E192G possibly damaging Het
Atg2a A G 19: 6,302,846 (GRCm39) K1019R possibly damaging Het
Atp2b1 A G 10: 98,839,010 (GRCm39) K613E possibly damaging Het
Carm1 T C 9: 21,498,258 (GRCm39) C421R probably damaging Het
Cdh17 A T 4: 11,795,671 (GRCm39) Y417F probably damaging Het
Cers1 A G 8: 70,782,660 (GRCm39) D10G possibly damaging Het
Clptm1l A C 13: 73,760,573 (GRCm39) M319L probably benign Het
Cntnap3 A G 13: 64,929,618 (GRCm39) V527A probably damaging Het
Creb3l2 A G 6: 37,332,625 (GRCm39) S290P probably damaging Het
Dock4 T G 12: 40,722,809 (GRCm39) V305G probably damaging Het
Dtl A C 1: 191,280,466 (GRCm39) L356R probably damaging Het
Eftud2 A T 11: 102,732,289 (GRCm39) probably null Het
Eif2b4 A G 5: 31,348,512 (GRCm39) S88P possibly damaging Het
Fat4 T G 3: 39,036,587 (GRCm39) V3413G possibly damaging Het
Fgfr2 T C 7: 129,801,578 (GRCm39) M218V probably benign Het
Grin2b A G 6: 135,900,269 (GRCm39) L204P probably damaging Het
Kcnj12 A G 11: 60,961,103 (GRCm39) N467S probably benign Het
Klhdc3 T A 17: 46,988,858 (GRCm39) N111Y possibly damaging Het
Lin9 A G 1: 180,486,676 (GRCm39) I81V probably null Het
Lrp2 T C 2: 69,331,892 (GRCm39) D1621G probably damaging Het
Lrp4 T A 2: 91,307,047 (GRCm39) D389E probably damaging Het
Med15 C T 16: 17,473,598 (GRCm39) probably benign Het
Nbea T C 3: 55,625,269 (GRCm39) N2274S probably benign Het
Nr3c2 G A 8: 77,635,343 (GRCm39) G148D probably damaging Het
Or10s1 A T 9: 39,985,605 (GRCm39) M5L probably benign Het
Or14j6 T C 17: 38,214,464 (GRCm39) V9A probably benign Het
Or4c112 G T 2: 88,853,770 (GRCm39) H192Q probably benign Het
Paxip1 A G 5: 27,977,027 (GRCm39) probably benign Het
Pfas T C 11: 68,880,779 (GRCm39) probably benign Het
Plin3 C A 17: 56,593,275 (GRCm39) A96S probably damaging Het
Pnck T A X: 72,700,550 (GRCm39) I288F probably damaging Het
Ppp4c C T 7: 126,386,499 (GRCm39) G166D probably damaging Het
Prss43 A T 9: 110,656,840 (GRCm39) R115S probably damaging Het
Rassf2 T C 2: 131,840,180 (GRCm39) probably null Het
Rdh16f1 T A 10: 127,624,568 (GRCm39) D135E probably benign Het
Rdh16f1 G A 10: 127,624,569 (GRCm39) V136M probably damaging Het
Rgs12 A G 5: 35,189,698 (GRCm39) E702G probably damaging Het
Rnf213 A G 11: 119,370,384 (GRCm39) K4728E probably damaging Het
Ros1 T G 10: 51,996,944 (GRCm39) T1243P probably benign Het
Sall1 G A 8: 89,758,101 (GRCm39) Q668* probably null Het
Sbf2 C A 7: 110,088,487 (GRCm39) *45L probably null Het
Serpina3j A T 12: 104,286,086 (GRCm39) I414F probably benign Het
Sh2d3c T C 2: 32,636,108 (GRCm39) Y159H probably damaging Het
Slamf1 A G 1: 171,625,745 (GRCm39) D307G probably null Het
Slc22a13 T C 9: 119,025,143 (GRCm39) T178A probably benign Het
Smchd1 A T 17: 71,736,536 (GRCm39) L588H probably damaging Het
Trim12a G A 7: 103,956,201 (GRCm39) A113V probably benign Het
Vil1 T C 1: 74,466,772 (GRCm39) V654A probably benign Het
Vmn1r202 T C 13: 22,686,070 (GRCm39) T116A possibly damaging Het
Zfp607a G A 7: 27,578,826 (GRCm39) R632H probably benign Het
Other mutations in Zfp267
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Zfp267 APN 3 36,218,729 (GRCm39) missense possibly damaging 0.86
IGL02089:Zfp267 APN 3 36,218,877 (GRCm39) missense possibly damaging 0.53
IGL02162:Zfp267 APN 3 36,218,210 (GRCm39) missense probably benign 0.18
R0243:Zfp267 UTSW 3 36,219,303 (GRCm39) missense possibly damaging 0.47
R0512:Zfp267 UTSW 3 36,220,262 (GRCm39) missense probably damaging 0.96
R0722:Zfp267 UTSW 3 36,219,218 (GRCm39) missense probably benign 0.35
R0762:Zfp267 UTSW 3 36,220,016 (GRCm39) missense possibly damaging 0.92
R0792:Zfp267 UTSW 3 36,218,711 (GRCm39) missense probably benign 0.01
R0894:Zfp267 UTSW 3 36,218,935 (GRCm39) nonsense probably null
R1731:Zfp267 UTSW 3 36,218,620 (GRCm39) missense probably benign 0.18
R2098:Zfp267 UTSW 3 36,220,289 (GRCm39) missense probably benign
R2099:Zfp267 UTSW 3 36,218,361 (GRCm39) missense possibly damaging 0.86
R3709:Zfp267 UTSW 3 36,213,725 (GRCm39) missense possibly damaging 0.71
R4035:Zfp267 UTSW 3 36,218,989 (GRCm39) missense possibly damaging 0.53
R4288:Zfp267 UTSW 3 36,213,747 (GRCm39) missense possibly damaging 0.71
R4289:Zfp267 UTSW 3 36,213,747 (GRCm39) missense possibly damaging 0.71
R4959:Zfp267 UTSW 3 36,218,285 (GRCm39) missense possibly damaging 0.91
R4973:Zfp267 UTSW 3 36,218,285 (GRCm39) missense possibly damaging 0.91
R5102:Zfp267 UTSW 3 36,216,814 (GRCm39) missense possibly damaging 0.73
R5462:Zfp267 UTSW 3 36,219,969 (GRCm39) missense possibly damaging 0.95
R5548:Zfp267 UTSW 3 36,219,640 (GRCm39) missense possibly damaging 0.90
R5782:Zfp267 UTSW 3 36,219,128 (GRCm39) missense possibly damaging 0.73
R6153:Zfp267 UTSW 3 36,219,303 (GRCm39) missense possibly damaging 0.47
R6225:Zfp267 UTSW 3 36,220,352 (GRCm39) missense probably benign 0.18
R6602:Zfp267 UTSW 3 36,219,004 (GRCm39) missense possibly damaging 0.86
R6785:Zfp267 UTSW 3 36,219,601 (GRCm39) nonsense probably null
R7513:Zfp267 UTSW 3 36,218,792 (GRCm39) missense possibly damaging 0.53
R7846:Zfp267 UTSW 3 36,219,738 (GRCm39) missense probably benign 0.43
R8120:Zfp267 UTSW 3 36,218,640 (GRCm39) missense possibly damaging 0.96
R8265:Zfp267 UTSW 3 36,213,677 (GRCm39) start gained probably benign
R8415:Zfp267 UTSW 3 36,219,182 (GRCm39) missense probably damaging 0.98
R8826:Zfp267 UTSW 3 36,218,255 (GRCm39) missense possibly damaging 0.86
R9026:Zfp267 UTSW 3 36,219,066 (GRCm39) missense possibly damaging 0.96
R9159:Zfp267 UTSW 3 36,219,902 (GRCm39) missense possibly damaging 0.47
R9786:Zfp267 UTSW 3 36,219,853 (GRCm39) nonsense probably null
X0021:Zfp267 UTSW 3 36,218,340 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- TTCATACGGGAGAAAAGCCCT -3'
(R):5'- CTCCTGTGTGAATTCTCTGGT -3'

Sequencing Primer
(F):5'- GCCCTACCATTGTAAAGACTGTGG -3'
(R):5'- CACAGTCTTGACACTTGTAGGGC -3'
Posted On 2015-04-02