Incidental Mutation 'R3810:Klhl35'
ID 275159
Institutional Source Beutler Lab
Gene Symbol Klhl35
Ensembl Gene ENSMUSG00000035298
Gene Name kelch-like 35
Synonyms 2810406K13Rik
MMRRC Submission 040880-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R3810 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 99115211-99123229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 99119448 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 311 (D311G)
Ref Sequence ENSEMBL: ENSMUSP00000041363 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037359] [ENSMUST00000152424]
AlphaFold Q9CZ49
Predicted Effect probably benign
Transcript: ENSMUST00000037359
AA Change: D311G

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000041363
Gene: ENSMUSG00000035298
AA Change: D311G

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
BTB 40 141 5.82e-17 SMART
BACK 146 248 1.21e-27 SMART
Kelch 292 341 6.32e-2 SMART
Kelch 342 385 1.18e-5 SMART
Kelch 386 432 3.01e-12 SMART
Kelch 433 480 2.23e-1 SMART
Kelch 481 522 2.71e-5 SMART
Kelch 523 570 1.39e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142339
Predicted Effect probably benign
Transcript: ENSMUST00000152424
SMART Domains Protein: ENSMUSP00000120346
Gene: ENSMUSG00000035298

DomainStartEndE-ValueType
Pfam:Kelch_1 1 34 1.1e-8 PFAM
Pfam:Kelch_6 36 79 3.6e-8 PFAM
Pfam:Kelch_1 38 76 2.6e-7 PFAM
low complexity region 106 119 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000153736
Meta Mutation Damage Score 0.1000 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd6 T A 14: 8,045,603 (GRCm38) V173D probably benign Het
Agbl3 G T 6: 34,776,664 (GRCm39) S385I probably damaging Het
Ahcyl2 A G 6: 29,891,260 (GRCm39) I455V probably benign Het
Bpifb2 T A 2: 153,733,871 (GRCm39) D404E probably benign Het
Ctbp1 A G 5: 33,424,389 (GRCm39) probably benign Het
D130040H23Rik T A 8: 69,755,022 (GRCm39) C160S probably damaging Het
Dapk1 T C 13: 60,908,503 (GRCm39) W1039R probably damaging Het
Dock6 T C 9: 21,712,873 (GRCm39) K1995E probably damaging Het
Entpd3 A G 9: 120,391,068 (GRCm39) E440G probably benign Het
Gm20939 G A 17: 95,184,138 (GRCm39) R262K possibly damaging Het
Gm9637 A T 14: 19,402,398 (GRCm38) noncoding transcript Het
Gm9847 T C 12: 14,545,148 (GRCm39) noncoding transcript Het
H2-Q6 A G 17: 35,644,757 (GRCm39) E182G probably damaging Het
Has1 T C 17: 18,067,822 (GRCm39) Y356C probably damaging Het
Hivep2 A G 10: 14,006,101 (GRCm39) T900A probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Metap2 A T 10: 93,706,026 (GRCm39) L252* probably null Het
Mrgpra9 T A 7: 46,885,527 (GRCm39) I47F probably damaging Het
Muc5b T C 7: 141,417,863 (GRCm39) L3603P possibly damaging Het
Neurl4 A G 11: 69,794,859 (GRCm39) H323R probably damaging Het
Oas1d A T 5: 121,053,049 (GRCm39) I35F probably damaging Het
Or4c124 G A 2: 89,156,098 (GRCm39) T142M probably benign Het
Or4c12b T A 2: 89,647,395 (GRCm39) S242T probably damaging Het
Or5w18 C T 2: 87,633,396 (GRCm39) S221F possibly damaging Het
Or5w19 T A 2: 87,698,745 (GRCm39) S137T probably damaging Het
Orc6 T A 8: 86,026,613 (GRCm39) S19R probably benign Het
Pcdh12 T C 18: 38,414,290 (GRCm39) E945G probably damaging Het
Plekha6 A G 1: 133,201,717 (GRCm39) M377V probably benign Het
Psmd1 T A 1: 86,060,437 (GRCm39) V828D probably damaging Het
Rbbp5 T C 1: 132,420,325 (GRCm39) V59A probably damaging Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Tas2r130 A G 6: 131,607,792 (GRCm39) M1T probably null Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Trgv2 T C 13: 19,521,011 (GRCm39) T28A possibly damaging Het
Trpc4ap T A 2: 155,485,355 (GRCm39) I448F probably damaging Het
Ttc21b C T 2: 66,082,577 (GRCm39) probably null Het
Txndc5 T C 13: 38,707,381 (GRCm39) K99E probably benign Het
Uvrag A G 7: 98,628,919 (GRCm39) Y383H probably damaging Het
Vim T C 2: 13,583,563 (GRCm39) probably null Het
Other mutations in Klhl35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02127:Klhl35 APN 7 99,120,888 (GRCm39) splice site probably benign
IGL03003:Klhl35 APN 7 99,119,550 (GRCm39) missense probably damaging 0.98
R0268:Klhl35 UTSW 7 99,120,958 (GRCm39) missense probably benign 0.33
R1563:Klhl35 UTSW 7 99,120,902 (GRCm39) missense probably damaging 1.00
R1770:Klhl35 UTSW 7 99,123,082 (GRCm39) missense possibly damaging 0.57
R1901:Klhl35 UTSW 7 99,119,427 (GRCm39) missense probably damaging 1.00
R2392:Klhl35 UTSW 7 99,123,031 (GRCm39) missense possibly damaging 0.72
R4194:Klhl35 UTSW 7 99,123,058 (GRCm39) splice site probably null
R4349:Klhl35 UTSW 7 99,122,926 (GRCm39) missense probably benign 0.18
R4960:Klhl35 UTSW 7 99,118,275 (GRCm39) missense probably damaging 1.00
R5846:Klhl35 UTSW 7 99,122,094 (GRCm39) missense probably damaging 0.97
R6161:Klhl35 UTSW 7 99,122,544 (GRCm39) unclassified probably benign
R6494:Klhl35 UTSW 7 99,122,106 (GRCm39) missense probably damaging 1.00
R7060:Klhl35 UTSW 7 99,117,665 (GRCm39) missense possibly damaging 0.81
R7758:Klhl35 UTSW 7 99,122,425 (GRCm39) missense unknown
R7762:Klhl35 UTSW 7 99,117,647 (GRCm39) missense probably benign 0.11
R8022:Klhl35 UTSW 7 99,122,446 (GRCm39) missense unknown
R8348:Klhl35 UTSW 7 99,121,062 (GRCm39) missense probably damaging 0.99
R8356:Klhl35 UTSW 7 99,122,129 (GRCm39) missense probably damaging 1.00
R8822:Klhl35 UTSW 7 99,122,055 (GRCm39) missense probably benign 0.00
R8927:Klhl35 UTSW 7 99,120,221 (GRCm39) missense probably damaging 1.00
R8928:Klhl35 UTSW 7 99,120,221 (GRCm39) missense probably damaging 1.00
R9072:Klhl35 UTSW 7 99,122,129 (GRCm39) missense probably damaging 1.00
R9202:Klhl35 UTSW 7 99,120,212 (GRCm39) missense probably benign 0.29
R9434:Klhl35 UTSW 7 99,119,547 (GRCm39) missense probably damaging 1.00
R9671:Klhl35 UTSW 7 99,117,702 (GRCm39) missense probably benign 0.13
X0023:Klhl35 UTSW 7 99,119,548 (GRCm39) nonsense probably null
X0064:Klhl35 UTSW 7 99,121,048 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGGTTCAGTAATCCCCAGC -3'
(R):5'- TGCTGGACCACACAGTTTTAG -3'

Sequencing Primer
(F):5'- AGTAATCCCCAGCACCGTTTGG -3'
(R):5'- TGGACCACACAGTTTTAGTCACTAAC -3'
Posted On 2015-04-02